2023・2022・2021
2023
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- S. Okada, Y. Muto, B. Zhu, H. Ueda, H. Nakamura
“Development of a peptide sensor derived from human ACE2 for fluorescence polarization assays of the SARS-CoV-2 receptor binding domain”, Anal. Chem., accepted (2023). DOI: 10.1021/acs.analchem.2c05818
- 三浦一輝、WEN Yijin、對馬理彦、中村浩之
“細胞内分子標的型光線力学療法”、日本レーザー医学会「特集 最新光感受性物質」accepted (2023).
- K.Tsujino, H. Kashiwagi, K. Nishimura, R. Kayama, K. Yoshimura, Y. Fukuo, H. Shiba, R. Hiramatsu, N. Nonoguchi, M. Furuse, T. Takami, S.-I. Miyatake, N. Hu, T. Takata, H. Tanaka, M. Suzuki, S. Kawabata, H. Nakamura, M. Wanibuchi
“Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model”, Biology, 12, 377 (2023). DOI: 10.3390/biology12030377.
- Y. Orita, S. Shimanuki, S. Okada, K. Nakamura, H. Nakamura, Y. Kitamoto, Y. Shimoyama, Y. Kurashina
“Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release”, Ultrason. Sonochem. 94, 106326 (2023). DOI:10.1016/j.ultsonch.2023.106326
- 岡田智、Rohmad Yudi Utomo、住吉晃、青木伊知男、中村浩之
“アミロイドβ線維化を検出・阻害するクルクミン誘導体MRIプローブの開発”、日本分子イメージング学会機関誌、16(1), 26-29 (2023).
- 盛田大輝、中村浩之
“イソオキサゾールの新規官能基化法の開発”、有機合成化学協会 81(3), 244-253 (2023).
- 中村浩之
“中性子捕捉療法の鍵を握る10B薬剤開発”、Precision Medicine「特集 イメージングによる最先端医薬品・医療技術開発」6(1), 28-32 (2023).
- K. Umedera, A. Yoshimori, H. Chen, H. Kouji, H. Nakamura, J. Bajorath
“DeepCubist: Molecular Generator for Designing Peptidomimetics Based on Complex Three-Dimensional Scaffolds”, J.Comput-Aided Mol. Des. 37, 107–115 (2023). DOI:10.1007/s10822-022-00493-y.
2022
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- K. Umedera, A. Yoshimori, J. Bajorath, H. Nakamura
“Design of MMP-1 Inhibitors via SAR Transfer and Experimental Validation”, Sci. Rep. 12, 20915 (2022). DOI: 10.1038/s41598-022-25079-4.
- K. Umedera, A. Yoshimori, H. Chen, H. Kouji, H. Nakamura, J. Bajorath
“DeepCubist: Molecular Generator for Designing Peptidomimetics Based on Complex Three-Dimensional Scaffolds”, J. Comput-Aided Mol. Des., online (2022). DOI:10.1007/s10822-022-00493-y.
- K. Umedera, T. Morita, H. Nakamura
“Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds for drug discovery”, Chem. Commun., online (2022). DOI:10.1039/D2CC05700J
- S. Ogawa, Y. Asawa, M. Iiyama, A. Yoshimori, H. Nakamura, M. Oda
“Regulation of binding between CD28 cytoplasmic region and SH2 domains of Grb2 and PI3K by carborane compounds for T-cell activation”, Bioorg. Med. Chem. Lett., 78, 129049 (2022). DOI:10.1016/j.bmcl.2022.129049
- K. Miura, Y. Wen, M. Tsushima, H. Nakamura
“Photodynamic therapy by glucose transporter 1–selective light inactivation”, ACS Omega, 7(38), 34685–34692. DOI:10.1021/acsomega.2c05042
- A. G. Beck-Sickinger, D. P. Becker, O. Chepurna, B. Das, S. Flieger, E. Hey-Hawkins, N. Hosmane, S. S. Jalisatgi, H. Nakamura, R. Patil, M. da Graça, H. Vicente, C. Viñas
“New Boron Delivery Agents”, Cancer Biother. Radiopharm., accepted, (2022).
- 中村浩之
“ホウ素の拓く創薬ワールド“、細胞「特集 低分子モダリティの進化―元素・光・分子機能に注目して」54(9), 492-495 (2022).
- A. M. Hughes, J. A. Goldfinger, M. A. Palmieri, P. Ramos, I. S. Santa Cruz, L. De Leo, M. A. Garabalino, S. I. Thorp, P. Curotto, E. C. C. Pozzi, K. Kawai, S. Sato, M. E. Itoiz, V. A. Trivillin, J. S. Guidobono, H. Nakamura, A. E. Schwint
“Boron neutron capture therapy (BNCT) mediated by maleimide-functionalized closo-dodecaborate albumin conjugates (MID:BSA) for oral cancer: Biodistribution studies and in vivo BNCT in the hamster cheek pouch oral cancer model”, Life, 12(7), 1082. DOI:10.3390/life12071082
- K. Nishimura, S. Harrison, K. Kawai, T. Morita, K. Miura, S. Okada, H. Nakamura
Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor”, Bioorg. Med. Chem. Lett., 72, 128869 (2022). DOI:10.1016/j.bmcl.2022128869
- S. Noda, A. Yamada, Y. Asawa, H. Nakamura, T. Matsumura, H. Orimo, and M. Goseki-Sone
“Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene”, J. Nutr. Sci. Vitaminol., 68, 284-293 (2022). DOI:10.3177/jnsv.68.284
- H. Kitamura, Y. Otake, N. Sugisawa, H. Sugisawa, T. Ida, H. Nakamura, S. Fuse
“Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous-Flow Reactor and Consideration of a Mechanism for Reduced Over-reaction through the Addition of Imidazole”, Chem. Eur. J., 28(37), e202200932. DOI:10.1002/chem.202200932
- 盛田大輝、中村浩之
“光反応を利用したタンパク質の化学修飾”, カレントレビュー, 43, 71-77 (2022).
- S. Koyama, H. Sato, H. Sugai, M. Murakoshi, T. Kobayashi, S. Usami, K. Ikeda, Y. Haga, K. Tsumoto, H. Nakamura, N. Hirasawa, K. Ishihara, H. Wada
“Effects of Salicylate Derivatives on Changes in Localization of H723R Pendrin Mutant Expressed in HEK293 Cells”, Auris Nasus Larynx., 49(6), 928-937 (2022). DOI: 10.1016/j.anl.2022.03.009
- K. Nakane, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, H. Nakamura, M. Ishikawa, S. Sato
“BODIPY Catalyzes Proximity‐Dependent Histidine Labelling”,
ChemCatChem., 14(9), e202200077 (2022). DOI:10.1002/cctc.202200077
- R. Y. Utomo, S. Okada, A. Sumiyoshi, I. Aoki, H. Nakamura
“Detoxification by curcumin derivative via dissociation of amyloid β fibrils and its verification in Drosophila Alzheimer’s model”, RSC Adv., 12, 5027-5030 (2022). DOI:10.1039/D2RA00614F
- R. Y. Utomo, A. Sugie, S. Okada, K. Miura, H. Nakamura
“Detoxification by curcumin derivative via dissociation of amyloid β fibrils and its verification in Drosophila Alzheimer’s model”, Chem. Commun., 58, 2576-2579 (2022). DOI:10.1039/D1CC07000B
- M. Tsuda, T. Morita, H. Nakamura
“Synthesis of isoxazoloazaborines via Gold(I)-catalyzed propargyl aza-Claisen rearrangement/borylative cyclization cascade”, Chem. Commun., 58, 1942-1945(2022). DOI:10.1039/D1CC07002A
Highlighted in Synfacts Issue 05/Volume 18/2022
- M. Tsushima, S. Sato, K. Miura, T. Niwa, H. Taguchi, H. Nakamura
“Intracellular Photocatalytic-Proximity Labeling for Profiling Protein–Protein Interactions in Microenvironments”, Chem. Commun., 58, 1926-1929 (2022). DOI:10.1039/D1CC05764B
- A. R Jalilian, A. Shahi, I. P. Swainson, H. Nakamura, M. Venkatesh, J. A. Osso Jr
“Potential theranostic BNCT agents as multimodal radiopharmaceuticals”, Cancer Biother. Radiopharm., 37(5), 342-354 (2022). DOI:10.1089/cbr.2021.0276
- T. Morita, H. Murakami, Y. Asawa, H. Nakamura
“Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N–H/B–H Double Activation of 1,2-Azaborines”, Angew. Chem. Int. Ed., 61, e202113558 (2022). DOI:10.1002/anie.202113558
Highlighted in Synfacts Issue 03/Volume 18/2022
- H. Ueda, P. Wipf, H. Nakamura
“Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities”, Bioorg. Med. Chem., 54, 116561 (2022). DOI:10.1016/j.bmc.2021.116561
- T.-H. Han, M. K. Park, H. Nakamura, H. S. Ban
“Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells”, Biomed. Pharm., 146, 112500 (2022). DOI:10.1016/j.biopha.2021.112500
- G. Li, G. Yu, C. Wang, T. Morita X. Zhang, H. Nakamura
“Copper(I)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites”, Org. Biomol. Chem., 20, 113-116 (2022). DOI:10.1039/D1OB02091A
- H. Kashiwagi, S. Kawabata, K. Yoshimura, Y. Fukuo, T. Kanemitsu, K. Takeuchi, R. Hiramatsu, K. Nishimura, K. Kawai, T. Takata, H. Tanaka, T. Watanabe, M. Suzuki, S. Miyatake, H. Nakamura, M. Wanibuchi
“Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model”, Investigational New Drugs, 40, 255–264 (2022). DOI:10.1007/s10637-021-01201-7
2021
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- Yanagie, M. Yanagawa, Y. Sakurai, K. Mouri, Y. Morishita, A. Shinohara, N. Dewi, Y. Nonaka, Y. Furuya, R. Mizumachi, Y. Murata, H. Nakamura, M. Suzuki, Y. Sakurai, H. Tanaka, S. Masunaga, K. Ono, T. Sugihara, M. Nashimoto, H. Yamauchi, M. Ono, J. Nakajima, H. Terada, H. Takahashi
“Tumour Growth Suppression in Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy with Liposomal Boron Delivery Systems”, In Vivo, 35(6), 3125-3135 (2021). DOI: 10.21873/invivo.12607
- Y. Asawa, S. Hatsuzawa, A. Yoshimori, K. Yamada, A. Katoh, H. Kouji, H. Nakamura
“Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes”, Sci. Rep., 11, 24101 (2021). DOI: 10.1038/s41598-021-03459-6
- Y. Tsuji, N. Nonoguchi, D. Okuzaki, Y. Wada, D. Motooka, Y. Hirota, T. Toho, N. Yoshikawa, M. Furuse, S. Kawabata, S.-I. Miyatake, H. Nakamura, R. Yamamoto, S. Nakamura, T. Kuroiwa, M. Wanibuchi
“Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression”, Sci. Rep., 11, 22110 (2021). DOI: 10.1038/s41598-021-01475-0
- Y. Asawa, K. Nishida, K. Domae, K. Kawai, H. S. Ban, H. Asami, J.-Y. Kohno, S. Okada, H. Tokuma, D. Sakano, S. Kume, M. Tanaka, H. Nakamura
“Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation”,
Bioconjugate Chem., 32(11), 2377–2385 (2021). DOI: 10.1021/acs.bioconjchem.1c00431
- S. Okada, S. Takayasu, A. Sumiyoshi, I. Aoki, H. Nakamura
“MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors”, Anal. Sci. 37, 12, 1765-1769 (2021) DOI: 10.2116/analsci.21P082
- S. Sato, M. Matsumura, H. Ueda, H. Nakamura
“Preparation of an antigen-responsive fluorogenic immunosensor by tyrosine chemical modification of the antibody complementarity determining region”, Chem. Commun., 57, 9760-9763 (2021). DOI: 10.1039/d1cc03231c
- G. Li, Y. Shao, Y. Pan, Y. Li, Y. Wang, L. Wan, K. Shao, S. Wang, H. Dong, X. W, X. Guo, W. Zhao, H. Nakamura
“Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy”, Bioorg. Med. Chem. Lett., 50, 128338 (2021). DOI:10.1016/j.bmcl.2021.128338
- R. Yudi Utomo, Y. Asawa, S. Okada, H. S. Ban, A. Yoshimori, J. Bajorath, H. Nakamura
“Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer’s disease using the SAR matrix approach”, Bioorg. Med. Chem., 46, 116357 (2021). DOI:10.1016/j.bmc.2021.116357
- N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse
“Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization”, Chemistry Methods, 1(11), 484-490 (2021). DOI:10.1002/cmtd.202100053
- K. Umedera, T. Morita, A. Yoshimori, K. Yamada, A. Katoh, H. Koji, H. Nakamura
“Synthesis of Three-Dimensional (3D) (Di)azatricyclododecene Scaffold and its Application to Peptidomimetics”, Chem. Eur. J., 27(46), 11888-11894 (2021). DOI:10.1002/chem.202101440
- M. Tsuda, T. Morita, H. Nakamura
“Suzuki-Miyaura Cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles”, Tetrahedron Lett., 75, 153185 (2021). DOI:10.1016/j.tetlet.2021.153185
- K. Nakane, S. Sato, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, M. Ishikawa, H. Nakamura
“Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen”, J. Am. Chem. Soc., 143(20), 7726–7731 (2021). DOI:10.1021/jacs.1c01626
- P. Singh, M. Kaur, K. Singh, G. Kaur, R. Meena, M. Kaur, B. Singh, A. Thakur, J. Sharma, A. Singh, M. Kumar, J. H. Yun, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
“Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy”, Phys. E: Low-Dimens. Syst. Nanostructures, 132, 114766 (2021). DOI:10.1016/j.physe.2021.114766
- S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura
“Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Micro-Flow Reactor”, Chem. Eur. J., 27(27), 7525-7532 (2021). DOI:10.1002/chem.202100059
- Y. Asawa, A. V. Arsent’eva, S. A. Anufriev, A. A. Anisimov, K. Y. Suponitsky, O. A. Filippov, H. Nakamura, I. B. Sivaev
“Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n– 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)”, Molecules, 26(5), 1321 (2021). DOI:10.3390/molecules26051321
- 中村 浩之
“BNCTの薬剤と中性子の反応”、月刊インナービジョン特集号、36(2), 40-42 (2021).
- M. Tsuda, S. Fukuhara, T. Morita, H. Nakamura
“Synthesis of 4-Amino-5-allenylisoxazoles via Gold(I)-Catalyzed Propargyl Aza-Claisen Rearrangement”, Org. Biomol. Chem.,19, 1358 (2021). DOI:10.1039/D0OB02544E
- S. Ban, Y. Uto, H. Nakamura
“Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)”, Expert Opin. Ther. Pat., 31(5), 387-397 (2021). DOI:10.1080/13543776.2021.1874345
- T. Shimizu, N. Takahashi, V. J. Huber, Y. Asawa, H. Ueda, A. Yoshimori, Y. Muramatsu, H. Seimiya, H. Kouji, H. Nakamura, H. Oguri
“Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α”,
Bioorg. Med. Chem., 30, 115949 (2021). DOI:10.1016/j.bmc.2020.115949
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