TOKYO INSTITUTE OF TECHNOLOGY, Chemical Resources Laboratory, Synthetic Organic Division, Nakamura & Okada Laboratory

Papers (2021〜Present)



          1. S. Noda, A. Yamada, Y. Asawa, H. Nakamura, T. Matsumura, H. Orimo, and M. Goseki-Sone,
            “Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene”, J. Nutr. Sci. Vitaminol., accepted (2022).
          2. H. Kitamura, Y. Otake, N. Sugisawa, H. Sugisawa, T. Ida, H. Nakamura, S. Fuse
            “Sequential Selective Introduction of Alcohols against Phosphorus Trichloride in a Continuous-Flow Reactor and Consideration of a Mechanism for Reduced Overreaction via the Addition of Imidazole”,
             Chem. Eur. J., 28, accepted (2022).
             ChemCatChem., accepted (2022). DOI:10.1002/cctc.202200077
          3. 盛田大輝、中村浩之
            “光反応を利用したタンパク質の化学修飾”, カレントレビュー, 43, 71-77 (2022).
          4. S. Koyama, H. Sato, H. Sugai, M. Murakoshi, T. Kobayashi, S. Usami, K. Ikeda, Y. Haga, K. Tsumoto, H. Nakamura, N. Hirasawa, K. Ishihara, H. Wada
            “Effects of Salicylate Derivatives on Changes in Localization of H723R Pendrin Mutant Expressed in HEK293 Cells”, Auris Nasus Larynx, accepted (2022).
          5.  K. Nakane, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, H. Nakamura, M. Ishikawa, S. Sato
            “BODIPY Catalyzes ProximityDependent Histidine Labelling”,
             ChemCatChem., accepted (2022). DOI:10.1002/cctc.202200077
          6. R. Y. Utomo, S. Okada, A. Sumiyoshi, I. Aoki, H. Nakamura
            “Detoxification by curcumin derivative via dissociation of amyloid β fibrils and its verification in Drosophila Alzheimer’s model”, RSC Adv., 12, 5027-5030 (2022). DOI:10.1039/D2RA00614F
          7. R. Y. Utomo, A. Sugie, S. Okada, K. Miura, H. Nakamura
            “Detoxification by curcumin derivative via dissociation of amyloid β fibrils and its verification in Drosophila Alzheimer’s model”, Chem. Commun., 58, 2576-2579 (2022). DOI:10.1039/D1CC07000B
          8. M. Tsuda, T. Morita, H. Nakamura
            “Synthesis of isoxazoloazaborines via Gold(I)-catalyzed propargyl aza-Claisen rearrangement/borylative cyclization cascade”, Chem. Commun., 58, 1942-1945(2022). DOI:10.1039/D1CC07002A
             Highlighted in Synfacts Issue 05/Volume 18/2022
          9. M. Tsushima, S. Sato, K. Miura, T. Niwa, H. Taguchi, H. Nakamura
            “Intracellular Photocatalytic-Proximity Labeling for Profiling Protein–Protein Interactions in Microenvironments”, Chem. Commun., 58, 1926-1929 (2022). DOI:10.1039/D1CC05764B
          10. A. R Jalilian, A. Shahi, I. P. Swainson, H. Nakamura, M. Venkatesh, J. A. Osso Jr
            “Potential theranostic BNCT agents as multimodal radiopharmaceuticals”, Cancer Biother. Radiopharm., accepted (2022).
          11. T. Morita, H. Murakami, Y. Asawa, H. Nakamura
            “Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N–H/B–H Double Activation of 1,2-Azaborines”, Angew. Chem. Int. Ed., 61, e202113558 (2022). DOI:10.1002/anie.202113558
             Highlighted in Synfacts Issue 03/Volume 18/2022
          12. H. Ueda, P. Wipf, H. Nakamura
            “Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities”, Bioorg. Med. Chem., 54, 116561 (2022). DOI:10.1016/j.bmc.2021.116561
          13. T.-H. Han, M. K. Park, H. Nakamura, H. S. Ban
            “Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells”, Biomed. Pharm., 146, 112500 (2022). DOI:10.1016/j.biopha.2021.112500
          14. G. Li, G. Yu, C. Wang, T. Morita X. Zhang, H. Nakamura
            “Copper(I)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites”, Org. Biomol. Chem., 20, 113-116 (2022). DOI:10.1039/D1OB02091A
          15. H. Kashiwagi, S. Kawabata, K. Yoshimura, Y. Fukuo, T. Kanemitsu, K. Takeuchi, R. Hiramatsu, K. Nishimura, K. Kawai, T. Takata, H. Tanaka, T. Watanabe, M. Suzuki, S. Miyatake, H. Nakamura, M. Wanibuchi
            “Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model”, Investigational New Drugs, 40, 255–264 (2022). DOI:10.1007/s10637-021-01201-7


          1. Yanagie, M. Yanagawa, Y. Sakurai, K. Mouri, Y. Morishita, A. Shinohara, N. Dewi, Y. Nonaka, Y. Furuya, R. Mizumachi, Y. Murata, H. Nakamura, M. Suzuki, Y. Sakurai, H. Tanaka, S. Masunaga, K. Ono, T. Sugihara, M. Nashimoto, H. Yamauchi, M. Ono, J. Nakajima, H. Terada, H. Takahashi
            “Tumour Growth Suppression in Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy with Liposomal Boron Delivery Systems”, In Vivo, 35(6), 3125-3135 (2021). DOI: 10.21873/invivo.12607
          2. Y. Asawa, S. Hatsuzawa, A. Yoshimori, K. Yamada, A. Katoh, H. Kouji, H. Nakamura
            “Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes”, Sci. Rep.11, 24101 (2021). DOI: 10.1038/s41598-021-03459-6
          3. Y. Tsuji, N. Nonoguchi, D. Okuzaki, Y. Wada, D. Motooka, Y. Hirota, T. Toho, N. Yoshikawa, M. Furuse, S. Kawabata, S.-I. Miyatake, H. Nakamura, R. Yamamoto, S. Nakamura, T. Kuroiwa, M. Wanibuchi
            “Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression”, Sci. Rep.11, 22110 (2021). DOI: 10.1038/s41598-021-01475-0
          4. Y. Asawa, K. Nishida, K. Domae, K. Kawai, H. S. Ban, H. Asami, J.-Y. Kohno, S. Okada, H. Tokuma, D. Sakano, S. Kume, M. Tanaka, H. Nakamura
            “Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation”,
            Bioconjugate Chem., 32(11), 2377–2385 (2021). DOI: 10.1021/acs.bioconjchem.1c00431
          5. S. Okada, S. Takayasu, A. Sumiyoshi, I. Aoki, H. Nakamura
            “MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors”, Anal. Sci. 37, 12, 1765-1769 (2021) DOI: 10.2116/analsci.21P082
          6. S. Sato, M. Matsumura, H. Ueda, H. Nakamura
            “Preparation of an antigen-responsive fluorogenic immunosensor by tyrosine chemical modification of the antibody complementarity determining region”, Chem. Commun., 57, 9760-9763 (2021).  DOI: 10.1039/d1cc03231c
          7. G. Li, Y. Shao, Y. Pan, Y. Li, Y. Wang, L. Wan, K. Shao, S. Wang, H. Dong, X. W, X. Guo, W. Zhao, H. Nakamura
            “Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy”, Bioorg. Med. Chem. Lett., 50, 128338 (2021). DOI:10.1016/j.bmcl.2021.128338
          8. R. Yudi Utomo, Y. Asawa, S. Okada, H. S. Ban, A. Yoshimori, J. Bajorath, H. Nakamura
            “Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer’s disease using the SAR matrix approach”, Bioorg. Med. Chem., 46, 116357 (2021).  DOI:10.1016/j.bmc.2021.116357
          9. N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse
            “Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization”, Chemistry Methods, accepted. DOI:10.1002/cmtd.202100053
          10. K. Umedera, T. Morita, A. Yoshimori, K. Yamada, A. Katoh, H. Koji, H. Nakamura
            “Synthesis of Three-Dimensional (3D) (Di)azatricyclododecene Scaffold and its Application to Peptidomimetics”, Chem. Eur. J., 27(46), 11888-11894 (2021). DOI:10.1002/chem.202101440
          11. M. Tsuda, T. Morita, H. Nakamura
            “Suzuki-Miyaura Cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles”, Tetrahedron Lett., 75, 153185 (2021). DOI:10.1016/j.tetlet.2021.153185
          12. K. Nakane, S. Sato, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, M. Ishikawa, H. Nakamura
            “Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen”, J. Am. Chem. Soc., 143(20), 7726–7731 (2021). DOI:10.1021/jacs.1c01626
          13. P. Singh, M. Kaur, K. Singh, G. Kaur, R. Meena, M. Kaur, B. Singh, A. Thakur, J. Sharma, A. Singh, M. Kumar, J. H. Yun, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
            “Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy”, Phys. E: Low-Dimens. Syst. Nanostructures, 132, 114766 (2021). DOI:10.1016/j.physe.2021.114766
          14. S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura
            “Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Micro-Flow Reactor”, Chem. Eur. J., 27(27), 7525-7532 (2021). DOI:10.1002/chem.202100059
          15. Y. Asawa, A. V. Arsent’eva, S. A. Anufriev, A. A. Anisimov, K. Y. Suponitsky, O. A. Filippov, H. Nakamura, I. B. Sivaev
            “Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n– 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)”, Molecules, 26(5), 1321 (2021). DOI:10.3390/molecules26051321
          16. 中村 浩之
            「BNCTの薬剤と中性子の反応」、月刊インナービジョン特集号36(2), 40-42 (2021).
          17. M. Tsuda, S. Fukuhara, T. Morita, H. Nakamura
            “Synthesis of 4-Amino-5-allenylisoxazoles via Gold(I)-Catalyzed Propargyl Aza-Claisen Rearrangement”, Org. Biomol. Chem.,19, 1358 (2021). DOI:10.1039/D0OB02544E
          18. S. Ban, Y. Uto, H. Nakamura
            “Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)”, Expert Opin. Ther. Pat., 31(5), 387-397 (2021). DOI:10.1080/13543776.2021.1874345
          19. T. Shimizu, N. Takahashi, V. J. Huber, Y. Asawa, H. Ueda, A. Yoshimori, Y. Muramatsu, H. Seimiya, H. Kouji, H. Nakamura, H. Oguri 
            “Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α”,
            Bioorg. Med. Chem., 30, 115949 (2021). DOI:10.1016/j.bmc.2020.115949



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