TOKYO INSTITUTE OF TECHNOLOGY, Chemical Resources Laboratory, Synthetic Organic Division, Nakamura & Okada Laboratory

Papers (2021〜Present)



        1. T. Morita, H. Murakami, Y. Asawa, H. Nakamura,
          “Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N–H/B–H Double Activation of 1,2-Azaborines”, Angew Chem. Int. Ed., accepted, (2022). DOI: 10.1002/anie.202113558
        2. T. Ueda, P. Wipf, H. Nakamura,
          “Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities”, Bioorg. Med. Chem., 54, 116561 (2022). DOI: 10.1016/j.bmc.2021.116561
        3. T.-H. Han, M. K. Park, H. Nakamura, H. S. Ban,
          “Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells”, Biomed. Pharm., 146, 112500 (2022). DOI: 10.1016/j.biopha.2021.112500
        4. G. Li, G. Yu, C. Wang, T. Morita X. Zhang, H. Nakamura, 
          “Copper(I)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites”, Org. Biomol. Chem.accepted, (2022). DOI: 10.1039/D1OB02091A


        1. Y. Asawa, S. Hatsuzawa, A. Yoshimori, K. Yamada, A. Katoh, H. Kouji, H. Nakamura,
          “Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes” Sci. Rep.11, 24101 (2021). DOI: 10.1038/s41598-021-03459-6
        2. H. Kashiwagi, S. Kawabata, K. Yoshimura, Y. Fukuo, T. Kanemitsu, K. Takeuchi, R. Hiramatsu, K. Nishimura, K. Kawai, T. Takata, H. Tanaka, T. Watanabe, M. Suzuki, S. Miyatake, H. Nakamura, M. Wanibuchi,
          “Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model” Investigational New Drugsaccepted, DOI:10.1007/s10637-021-01201-7
        3. Y. Tsuji, N. Nonoguchi, D. Okuzaki, Y. Wada, D. Motooka, Y. Hirota, T. Toho, N. Yoshikawa, M. Furuse, S. Kawabata, S.-I. Miyatake, H. Nakamura, R. Yamamoto, S. Nakamura, T. Kuroiwa, M. Wanibuchi,
          “Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression”, Sci. Rep.11, 22110 (2021). DOI: 10.1038/s41598-021-01475-0
        4. Y. Asawa, K. Nishida, K. Domae, K. Kawai, H. S. Ban, H. Asami, J.-Y. Kohno, S. Okada, H. Tokuma, D. Sakano, S. Kume, M. Tanaka, H. Nakamura,
          “Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation”
          Bioconjugate Chem., 32(11), 2377–2385 (2021). DOI: 10.1021/acs.bioconjchem.1c00431
        5. S. Okada, S. Takayasu, A. Sumiyoshi, I. Aoki, H. Nakamura,
          “Application of Magnetic Nanoparticles for MRI-Based Glucose Assay”, Anal. Sci. accepted.  DOI: 10.2116/analsci.21P082
        6. S. Sato, M. Matsumura, H. Ueda, H. Nakamura,
          “Preparation of an antigen-responsive fluorogenic immunosensor by tyrosine chemical modification of the antibody complementarity determining region” ChemComm., 57, 9760-9763 (2021).  DOI: 10.1039/d1cc03231c
        7. G. Li, Y. Shao, Y. Pan, Y. Li, Y. Wang, L. Wan, K. Shao, S. Wang, H. Dong, X. W, X. Guo, W. Zhao, H. Nakamura,
          “Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy”, Bioorg. Med. Chem. Lett., 50, 128338 (2021). DOI:10.1016/j.bmcl.2021.128338
        8. R. Yudi Utomo, Y. Asawa, S. Okada, H. S. Ban, A. Yoshimori, J. Bajorath, H. Nakamura,
          “Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer’s disease using the SAR matrix approach”, Bioorg. Med. Chem., 46, 116357 (2021).  DOI:10.1016/j.bmc.2021.116357
        9. N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse
          “Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization”, Chemistry Methods, accepted. DOI:10.1002/cmtd.202100053
        10. K. Umedera, T. Morita, A. Yoshimori, K. Yamada, A. Katoh, H. Koji, H. Nakamura
          “Synthesis of Three-Dimensional (3D) (Di)azatricyclododecene Scaffold and its Application to Peptidomimetics”, Chem. Eur. J., 27(46), 11888-11894 (2021). DOI:10.1002/chem.202101440
        11. M. Tsuda, T. Morita, H. Nakamura
          “Suzuki-Miyaura Cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles”, Tetrahedron Lett., 75, 153185 (2021). DOI:10.1016/j.tetlet.2021.153185
        12. K. Nakane, S. Sato, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, M. Ishikawa, H. Nakamura
          “Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen”, J. Am. Chem. Soc., 143(20), 7726–7731 (2021). DOI:10.1021/jacs.1c01626
        13. P. Singh, M. Kaur, K. Singh, G. Kaur, R. Meena, M. Kaur, B. Singh, A. Thakur, J. Sharma, A. Singh, M. Kumar, J. H. Yun, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
          “Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy”, Phys. E: Low-Dimens. Syst. Nanostructures, 132, 114766 (2021). DOI:10.1016/j.physe.2021.114766
        14. S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura
          “Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Micro-Flow Reactor”, Chem. Eur. J., 27(27), 7525-7532 (2021). DOI:10.1002/chem.202100059
        15. Y. Asawa, A. V. Arsent’eva, S. A. Anufriev, A. A. Anisimov, K. Y. Suponitsky, O. A. Filippov, H. Nakamura, I. B. Sivaev
          “Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n– 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)”, Molecules, 26(5), 1321 (2021). DOI:10.3390/molecules26051321
        16. 中村 浩之
          「BNCTの薬剤と中性子の反応」、月刊インナービジョン特集号36(2), 40-42 (2021).
        17. M. Tsuda, S. Fukuhara, T. Morita, H. Nakamura
          “Synthesis of 4-Amino-5-allenylisoxazoles via Gold(I)-Catalyzed Propargyl Aza-Claisen Rearrangement”, Org. Biomol. Chem.,19, 1358 (2021).DOI: 10.1039/D0OB02544E
        18. S. Ban, Y. Uto, H. Nakamura
          “Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)”, Expert Opin. Ther. Pat., 31(5), 387-397 (2021). DOI: 10.1080/13543776.2021.1874345
        19. T. Shimizu, N. Takahashi, V. J. Huber, Y. Asawa, H. Ueda, A. Yoshimori, Y. Muramatsu, H. Seimiya, H. Kouji, H. Nakamura, H. Oguri 
          “Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α”
          Bioorg. Med. Chem., 30, 115949 (2021). DOI:10.1016/j.bmc.2020.115949



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