東京工業大学 科学技術創成研究院 化学生命科学研究所 中村・布施研究室

発表論文

201720162015201420132012201120102009~2008

2017

“Thiophene-based, Organic D-π-A dyes as Potent Sensitizers for Photodynamic Therapy” S. Fuse, M. Takizawa, K. Matsumura, S. Sato, S. Okazaki, H. Nakamura, Eur. J. Org. Chem. (34), 5170–5177 (2017). LINK

チオフェン含有有機Donor-p-Acceptor色素の系統的合成と構造-機能相関解明 布施新一郎、有機合成化学協会誌、75(9), 941-954 (2017).

“Development of Albumin-closo-Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3-Photocatalyzed Modification of Tyrosine” S.Sato, S Ishii, H Nakamura, Eur. J. Inorg.  DOI:10.1002/ejic.201700578 LINK

血清アルブミンを利用したホウ素デリバリーシステム 中村浩之、BIO Clinica, 32(7), 669-703 (2017) LINK

“Integrated Micro-flow Synthesis Based on Photochemical Wolff Rearrangement” (micro review) S. Fuse, Y. Otake, H. Nakamura Eur. J. Org. Chem. early view LINK

“Selective Purification and Chemical Labeling of Target Protein on Ruthenium Photocatalyst-Immobilized Affinity Beads” M. Tsushima, S. Sato, H. Nakamura Chem. Commun. 53, 4838-4841 (2017). LINK

“Discovery of (2-Aminophenyl)methanol as a New Molecular Chaperone That Rescues the Localization of P123S Mutant Pendrin Stably Expressed in HEK293 Cells” W. Nabeyama, K. Ishihara, H. S. Ban, H. Wada, H. Nakamura, Bioorg. Med. Chem. 25(9), 2601–2608 (2017). LINK

“Step-by-Step Multifunctionalization of Isoxazoles based on SEAr Reactions and C-H Direct Arylations.” (short review) S. Fuse, T. Morita, H. Nakamura, Synthesis 49(11), 2351-2360 (2017). LINK

“Solution-phase automated synthesis of α-amino aldehyde as a versatile intermediate.” H. Masui, S. Yosugi, S. Fuse, T. Takahashi, Beilstein J. Org. Chem. 13, 106-110 (2017).  LINK

“Horseradish-Peroxidase-Catalyzed Tyrosine Click Reaction” S. Sato, K. Nakamura, H. Nakamura, ChemBioChem. 18(5), 475–478 (2017).  LINK

2016

“The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore” G. Dormán, H. Nakamura, A. Pulsipher, G. D. Prestwich, Chem. Rev. 116(24), 15284–15398 (2016). LINK

“Effective Photodynamic Therapy in Drug-resistant Prostate Cancer Cells Utilizing a Non-viral Antitumor Vector (a secondary publication).” M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu, Laser therapy. 25(1), 55-62 (2016).  LINK

“A Rapid and Clean Synthetic Approach to Cyclic Peptides via Micro-flow Peptide Chain Elongation and Photochemical Cyclization: Synthesis of a Cyclic RGD Peptide” Y. Mifune, H. Nakamura, S. Fuse, Org. Biomol. Chem. 14(47), 11244-11249 (2016).  LINK

“Development of 1-Aryl-3-furanyl/Thienyl-imidazopyridine Templates for Inhibitors against Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity” S. Fuse, T. Ohuchi, Y. Asawa, S. Sato, H. Nakamura, Bioorg. Med. Chem. Lett. 26(24), 5887–5890(2016) LINK

“Total Synthesis of Feglymycin based on a Linear/Convergent Hybrid Approach using Micro-flow Amide Bond Formation” S. Fuse, Y. Mifune, H. Nakamura, H. Tanaka, Nat. Commun. 7, 13491 (2016).  LINK

“The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-pyridyl-xanthones for Use as Insecticides Starting from Pyripyropene A” S. Fuse, K. Matsumura, K. Johmoto, H. Uekusa, H. Tanaka, T. Hirose, T. Sunazuka, S. Ōmura, T. Takahashi, Chem. Eur. J. 22(51), 18450-18455 (2016). LINK Selected as a Hot Paper

“Generation of 4-Isoxazolyl Anion Species: Facile Access to 4-Substituted Isoxazoles” T. Morita, S. Fuse, H. Nakamura, Angew. Chem. Int. Ed. 55(43), 13580-13584 (2016). LINK Highlighted in Synfacts issue 12/2016

“Maleimide-Functionalized closo-Dodecaborate Albumin Conjugates (MID-AC): The Unique Ligation at both Cysteine and Lysine Residues Enabling to Efficient Boron Delivery to Tumor for Neutron Capture Therapy” S. Kikuchi, D. Kanoh, S. Sato, Y. Sakurai, M. Suzuki, H. Nakamura J. Control. Release (237)160–167 (2016). LINK

“The Synthesis of trans-Flavan-3-ol Gallates by Regioselective Oxidative Etherification and Their Biological Evaluation” N. Shiraishi, M. Kumazoe, S. Fuse, H. Tachibana, H. Tanaka Chem. Eur. J. 22(37), 13050-13053 (2016). LINK

“Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles” G. Li, H. Nakamura, Angew. Chem. Int. Ed. 55(23), 6758-6761 (2016).  LINK

“6-Azido-6-deoxy-L-idose as a Hetero-bifunctional Spacer for the Synthesis of Azido-containing Chemical Probes” H. Hamagami, M. Kumazoe, Y. Yamaguchi, S. Fuse, H. Tachibana, H. Tanaka, Chem. Eur. J. 22(36), 12884-12890 (2016). LINK

“Synthesis of Asymmetrically Terminal Bifunctionlized Alkanes by Sequential Suzuki-Miyaura Coupling using B-Thexyl Boracyclanes” R. Suzuki, S. Fuse, H. Tanaka, Eur. J. Org. Chem. (21), 3478–3481 (2016). LINK

“Hypoxia-Inducible Factor Inhibitors: A Patent Review (2011-2015)” S. Ban, Y. Uto, M. Won, H. Nakamura Exp. Opin. Ther. Pat. 26(3), 309–322 (2016). LINK

“Novel Hyaluronan Formulation Enhances the Efficacy of Boron Neutron Capture Therapy for Murine Mesothelioma” M. Sasai, H. Nakamura, N. Sougawa, Y. Sakurai, M. Suzuki, A. Matsuyama, C. M. Lee, Anticancer Res. 36(3), 907-911 (2016). LINK

“The α-Glycosidation of Partially Unprotected N-Acetyl and N-Glycolyl Sialyl Donors in the Absence of a Nitrile Solvent Effect” T. Aoyagi, S. Ohira, ,S. Fuse J. Uzawa, Y. Yamaguchi, H. Tanaka Chem. Eur. J. 22(20), 6968-6973 (2016). LINK

“Synthesis of D-A’-π-A Dyes via One-Pot Three-Component Suzuki-Miyaura Coupling and an Evaluation of the Photovoltaic Properties for Use in DSSCs” S. Irie, S. Fuse, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, H. Masui, H. Tanaka, T. Takahashi, Chem. Eur. J. 22(7), 2507-2514 (2016). LINK

“Synthesis and Evaluation of Thiophene-based Organic Dyes Containing a Rigid and Non-Planar Donor with Secondary Electron Donors for Use in Dye-Sensitized Solar Cells” S. Fuse, R. Takahashi, M. M. Maitani, Y. Wada, T. Kaiho, H. Tanaka, T. Takahashi, Eur. J. Org. Chem. (3), 508-517 (2016). LINK

2015

“Proteomic Analysis of Cellular Response Induced by Boron Neutron Capture Reaction in Human Squamous Cell Carcinoma SAS Cells,” A. Sato, T. Itoh, S. Imamichi, S. Kikuhara, H. Fujimori, T. Hirai, S. Saito, Y. Sakurai, H. Tanaka, H. Nakamura, M. Suzuki, Y. Murakami, D. Baiseitov, K. Berikkhanova, Z. Zhumadilov, Y. Imahori, J. Itami, K. Ono, S. Masunaga, M. Masutani, Appl. Radiat. Isotope, 106, 213-219 (2015). LINK

“Localization-Dependent Cell-Killing Effects of Protoporphyrin (PPIX)-Lipid Micelles and Liposomes in Photodynamic Therapy” S. Tachikawa, S. Sato, H. Hazama, Y. Kaneda, K. Awazu, H. Nakamura, Bioorg. Med. Chem. 23(24), 7578-7584 (2015). LINK

“ワンポット多成分連結反応を基盤とした機能性分子のコンビナトリアル合成” 増井悠、布施新一郎、高橋孝志、 Organometallic News. (3), 100-104 (2015). LINK

“Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives” S. Sato, K. Nakamura, H. Nakamura, ACS Chem. Biol. 10(11), 2633-2640 (2015). LINK

サイト選択的マイクロフロー反応を駆使する天然物合成 布施新一郎 化学と工業 68(8), 733-734 (2015).

“A Facile Preparation of α-Aryl Carboxylic Acid via One-flow Arndt-Eistert Synthesis” S. Fuse, Y. Otake, Y. Mifune, H. Tanaka, Aust. J. Chem. (invited) (2015). 68(11), 1657-1661 (2015). LINK

“Directing Group/Protecting Group-Free Synthesis of Tetraaryl-Substituted Pyrazoles via Four Direct Arylations on an Unsubstituted Pyrazole Scaffold” S. Fuse, T. Morita, K. Johmoto, H. Uekusa, H. Tanaka, Chem. Eur. J. 21(41), 14370-14375 (2015). LINK Selected as an Inside Cover Picture, Selected as a Hot Paper

“Synthesis of Oligo-closo-dodecaborates by Hüisgen Click Reaction as Encapsulated Agents for Preparation of High-Boron-Content Liposomes for Neutron Capture Therapy” H. Koganei, S. Tachikawa, M. E. El-Zaria, H. Nakamura, New J. Chem. (39), 6388-6394 (2015). LINK

“Palladium-Catalyzed Double Carbonylation-Based Diversity-Oriented Synthesis of 3,4-Dihydroisoquinoline-1-Carboxamides” H. Masui, N. Ishizawa, S. Fuse, T. Takahashi, Tetrahedron, 71(37), 6354-6360 (2015). LINK

“Synthesis and Biological Evaluation of meta-Carborane-Containing phenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1 ” G. Li, S. Azuma, H. Minegishi, H. Nakamura, J. Organomet. Chem. 798(1), 189-195 (2015). LINK

“Regio-Selective, One-pot, Three-component Synthesis of 1,3,4- and 1,3,5-Triaryl Pyrazoles from 1- and 2-Aryl-1-Alkenyl Sulfones” S. Fuse, H. Sugiyama, D. Kobayashi, Y. Iijima, K. Matsumura, H. Tanaka, T. Takahashi, Eur. J. Org. Chem. (21), 4756-4764 (2015). LINK

“Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles” T. Morita, D. Kobayashi, K. Matsumura, K. Johmoto, H. Uekusa, S. Fuse, T. Takahashi, Chem. Asian J. 10(8), 1626-1630 (2015). LINK Selected as a Front Cover Picture, Selected as Wiley Hottest Articles in Organic Chemistry

マイクロフロー光反応・イミドイル化反応・アシル化反応を駆使する効率的な有機合成 布施新一郎、高橋孝志 有機合成化学協会誌、73(5), 442-451 (2015).

“Asymmetric Total Synthesis of ent-Pyripyropene A” S. Fuse, A. Ikebe, K. Oosumi, T. Karasawa, K. Matsumura, M. Izumikawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Doi, T. Takahashi, Chem. Eur. J. 21(26), 9454-9460 (2015). LINK

“Rapid Synthesis of Thiophene-Based, Organic Dyes for DSSCs via a One-Pot, Four-Component Coupling Approach” K. Matsumura, S. Yoshizaki, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, S. Fuse, H. Tanaka, T. Takahashi, Chem. Eur. J.  21(27), 9742-9747 (2015). LINK

“Facile, One-Step Synthesis of 5-Substituted Thieno[3,4-c]pyrrole-4,6-dione by Palladium-Catalyzed Carbonylative Amidation” S. Fuse, R. Takahashi, T. Takahashi, Eur. J. Org. Chem. (16), 3430-3434 (2015). LINK

抗腫瘍効果を持つ非ウイルスベクター用いた薬剤耐性前立腺がん細胞に対する高効率な光線力学療法 山内将哉、本多典広、間久直、立川将士、中村浩之、金田安史、粟津邦男 レーザー医学会 36(1), 18-24 (2015).

“ortho-Carboranylphenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1Transcriptional Activity and Heat Shock Protein (HSP) 60 Chaperon Activity” G. Li, S. Azuma, S. Sato, H. Minegishi, H. Nakamura, Bioorg. Med. Chem. Lett. 25(13), 2524-2628 (2015). LINK

“Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods” H. Minegishi, Y. Futamura, S. Fukashiro, M. Muroi, M. Kawatani, H. Osada, H. Nakamura, J. Med. Chem. 58(10), 4230-4241 (2015). LINK

“C(sp3)–H versus C(sp3)–C(sp) in Activation of Propargylic Amines under Transition-Metal Catalysis” H. Nakamura, Synlett 26(12), 1649-1664  LINK

“Boron-Based Drug Design” H. S. Ban and H. Nakamura, Chem. Rec. 15(3), 616-635 (2015) LINK

“Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst” S. Sato, K. Morita, H. Nakamura, Bioconjugate Chem. 26(2), 250-256 (2015). LINK

“Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity” H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, Pure Appl. Chem. 87(2), 145-154 (2015). LINK

“Antitumor Effect of Boron Nitride Nanotubes in Combination with Thermal Neutron Irradiation on BNCT” H. Nakamura, H. Koganei, T. Miyoshi, Y. Sakurai, K. Ono, M. Suzuki, Bioorg. Med. Chem. Lett. 25(2), 172-174 (2015). LINK

ホウ素化合物・薬剤の歴史と現状 中村浩之、 RADIOISOTOPES 64(1), 47-58 (2015). LINK

2014

薬剤耐性前立腺がん細胞への PDTの検討 =非ウィルスベクターとPpIX脂質を用いた新規光感受性薬剤の開発= 粟津邦男、金田安史、山内将哉、中村浩之 月刊 光アライアンス 特集号「がんを抑え込む光線治療」25(9), 17-22 (2014).

がん光線力学療法のためのDDS薬剤の開発:ポルフィリン脂質の開発とナノキャリアへの応用 立川将士、中村浩之 月刊 光アライアンス 特集号「がんを抑え込む光線治療《25(9), 12-16 (2014).

“Spermidinium Closo-dodecaborate-encapsulating Liposomes as Efficient Boron Delivery Vehicles for Neutron Capture Therapy” S. Tachikawa, T. Miyoshi, H. Koganei, M. E. El-Zaria, C. Viñas, M. Suzuki, K. Ono, H. Nakamura, Chem. Commun. 50(82), 12325-12328 (2014). LINK(open access)

“Protoporphyrin-Lipids: Their Synthesis, Liposomal Formation and Efficient Delivery to Tumor” S. Tachikawa, M. E. El-Zaria, R. Inomata, S. Sato, H. Nakamura, Bioorg. Med. Chem. 22(17) 4745–4751 (2014). LINK

“Design of Photoaffinity Probe Molecules for Identification and Modification of Target Proteins” H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, S. Sato, J. Photopolym. Sci. Technol. 27(4) 453-458 (2014). LINK

“V843I, a Lung Cancer Predisposing EGFR Mutation, is Responsible for Resistance to EGFR Tyrosine Kinase Inhibitors” S. Matsushima, K. Ohtsuka, H. Ohnishi, M. Fujiwara, H. Nakamura, T. Morii, H. Goto, T. Watanabe, J. Thor. Oncol. 9(9) 1377-1384 (2014). LINK

“Reactivity of Propargylic Amines in the Presence of Transition Metals” T. Sugiishi, H. Nakamura, J. Syn. Org. Chem. 72, 654-665 (2014).

“Amphiphilic COSAN and I2-COSAN Crossing Synthetic Lipid Membranes: Planar Bilayers and Liposomes” C. Verdia-Baguena, A. Alcaraz, V. M. Aguilella, A. M. Cioran, S. Tachikawa, H. Nakamura, F. Teixidor, Clara. Vinas, Chem. Commun. 50, 6700-6703 (2014). LINK

“Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors” H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, H. H. Ban, J. Chem. Soc., Dalton Trans. (invited), 43(13), 4941-4944 (2014). LINK

“A novel photodynamic therapy for drug resistant prostate cancer cells using porphyrus Envelope as a novel photosensitizer” M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu, Photodiag. Photodynam. Ther. 11(1), 48-54 (2014). LINK

2013

“Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy” H. Nakamura, Yakugaku Zasshi (Review), 133(12), 1297-1306 (2013). LINK

“Ligand-directed Selective Protein Modification Based on Local Single Electron Transfer Catalysis” S. Sato, H. Nakamura, Angew. Chem. Int. Ed. 52, 8681-8684 (2013). LINK

“Synthesis and Biological Evaluation of ortho-Carborane Containing Benzoxazole as an Inhibitor of Hypoxia Inducible Factor (HIF)-1Transcriptional Activity” H. Nakamura, Y. Yasui, H. S. Ban, J. Organomet. Chem. (special issue) 747, 189-194 (2013). LINK

“Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors” H. Minegishi, S. Fukashiro, H. S. Ban, H. Nakamura, ACS Med. Chem. Lett. 4, 297-301 (2013). LINK

“Boron Cluster Lipid Liposomes as New Vehicles for Boron Delivery System of Neutron Capture Therapy” H. Nakamura, Future Med. Chem. (invited) 5(6), 715-730(2013). LINK

“Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their cholesterol conjugates” M. Bialek-Pietras, A. B. Olejniczak, S. Tachikawa, H. Nakamura, Z. J. Lesnikowski, Bioorg. Med. Chem. 21, 1136-1142 (2013). LINK

“Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity” H. Minegishi, T. Matsukawa, H. Nakamura, ChemMedChem. 8, 265-271 (2013). LINK Selected as an Inside Cover Picture

“Development of Hypoxia-Inducible Factor (HIF)-1α Inhibitors: Effect of ortho-Carborane Substituents on HIF Transcriptional -Activity under Hypoxia” H. Nakamura, Y. Yasui, M. Maruyama, H. Minegishi, H. S. Ban, S. Sato, Bioorg. Med. Chem. Lett. 23, 1455-1461 (2013). LINK

“Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers” H. Koganei, M. Ueno, S. Tachikawa, L. Tasaki, H. S. Ban, M. Suzuki, K. Shiraishi, K. Kawano, M. Yokoyama, Y. Maitani, K. Ono, H. Nakamura, Bioconjugate Chem. 24, 124-132 (2013). LINK

“HSP60 as a drug target” H. Nakamura, H. Minegishi, Curr. Pharm. Des. (Review) 19(3), 441-451 (2013). LINK

2012

蛍光標識ホウ素脂質の開発とリポソーム化による細胞内イメージング 上田記子、小金井逸人、上野学、立川将士、鈴木実、小野公二、中村浩之、 Progress in Drug Delivery System XXI, 68-73 (2012).

“Synthesis and Biological Evaluation of Furylindazoles as Hypoxia Inducible Factor (HIF)-1α Inhibitors” A. Takeuchi, M. Hori, S. Sato, H. S. Ban, T. Kuchimaru, S. Kizaka-Kondoh, T. Yamori, H. Nakamura, Med. Chem. Commun. 3, 1455-1461 (2012). LINK

“Discovery of 1-[4-(N-Benzylamino)phenyl]-3-phenylurea Derivatives as Non-Peptidic Selective SUMO-Sentrin Specific Protease (SENP)1 Inhibitors” M. Uno, Y. Koma, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 22, 5169-5173 (2012). LINK

“Copper(I)-catalysed Deacetylenative Cross-coupling Reaction of Terminal Alkynes with Propargylic Amines via C(sp)-C(sp3) Bond Cleavage” Y. Kim, H. Nakamura, Synlett. 23, 1686-1690 (2012). LINK

“In vitro Investigation of Efficient Photodynamic Therapy Using Non-viral Vector; Hemagglutinating Virus of Japan Envelope” N. Fujimoto, M. Sakai, K. Ishii, H. Nakamura, Y. Kaneda, K. Awazu, J. Biomed. Opt. 17(7), 078002 (Jul 17, 2012). LINK

“Identification of Heat Shock Protein 60 as the Regulator of the Hypoxia-inducible Factor Sub-unit HIF-1α” H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura, Pure Appl. Chem. 84(11), 2325-2337 (2012). LINK

“Synthesis and Biological Evaluation of Boronic Acid Containing Phenstatin Analogues” H. Nakamura, H. Kuroda, H. Minegishi, ARKIVOC. (2012)(vii), 79-87. LINK

“Zinc(II)-Catalyzed Redox Cross-Dehydrogenative Coupling of Propargylic Amines and Terminal Alkynes for Synthesis of N-Tethered 1,6-Enynes” T. Sugiishi, H. Nakamura, J. Am. Chem. Soc. 134, 2504-2507 (2012). LINK

“Design and Synthesis of Fluorescence-labeled Closo-dodecaborate Lipid: Liposome Formation and in vitro and in vivo Imaging Targeting to Tumor for Boron Neutron Capture Therapy” H. Nakamura, N. Ueda, H. B. Ban, M. Ueno, S. Tachikawa, Org. Biomol. Chem. 10, 1374-1380 (2012). LINK

2011

今後、治療の多様化に適応できるホウ素薬剤の開発を 中村浩之, エネルギーレビュー, 特集:岐路に立つホウ素中性子捕捉療法, 31(11), 17-18 (2011). LINK

“Facile Synthesis of 4-Substituted 3,4-Dihydro-1H-2,1,3-Benzothiadiazine 2,2-Dioxides” C.-H Lee, G. F. Jin, H. W. Lim, E. H. Yang, J.-D. Lee, H. Nakamura, H. S. Ban, S. O. Kang, Heteroatom Chem. 22, 192-197 (2011). LINK

“Copper(I)-catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes” Y. Kim, H. Nakamura, Chem. Eur. J. 17, 12561-12563 (2011). LINK

“Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors” H. Nakamura, A. Shoji, A. Takeuchi, H. B. Ban, J.-D. Lee, T. Yamori, S. O. Kang, Aust. J. Chem. 64 (11), 1430-1437 (2011). LINK

“Amphiphilic Allylation of Arylidene-1,3-oxazol-5(4H)-one Using Bis-π-allylpalladium Complexes: An Approach to Synthesis of Cyclohexyl and Cyclohexenyl α-Amino Acid” A. R. Genady, H. Nakamura, Org. Biomol. Chem. 9, 7180-7189 (2011). LINK

“Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers” Y. Ito, T. Mizuno, K. Yoshino, H.S. Ban, H. Nakamura, J. Hiratsuka, A. Ishikawa, H. Ohki, Appl. Radiat. Isotope. 69(12), 1771-1773 (2011). LINK

“m-Carborane-Based Chiral NBN Pincer-Metal Complexes: Synthesis, Structure, and Application in Asymmetric Catalysis” M. E. El-Zaria, H. Arii, H. Nakamura, Inorg. Chem. 50(9), 4149-4161(2011). LINK

“Hypoxia-Inducible Factor Inhibitors: A Survey of Recent Patented Compounds (2004-2010)” H. S. Ban, Y. Uto, H. Nakamura, Exp. Opin. Ther. Patents, (invited)21(2), 131-146 (2011). LINK

“Catalytic Reactions of Bis-π-allylpalladium Generated from Allyltrifluoroborate” H. Nakamura, K. Shimizu, Tetrahedron Lett. 52(3), 426-429 (2011). LINK

2010

“Minimally Invasive Cytoselective Radiation Therapy Using Boron Neutron Capture Reaction” H. Nakamura, YAKUGAKU ZASSHI 130(12) 1687-1694 (2010).

“Salicylate Restores Transport Function and Anion Exchanger Activity of Missense Pendrin Mutations” K. Ishihara, S. Okuyama, S. Kumano, K. Iida, H. Hamana, M. Murakoshi, T. Kobayashi, S. Usami, K. Ikeda, Y. Haga, K. Tsumoto, H. Nakamura, N. Hirasawa, H. Wada, Hearing Res. 270, 110-118 (2010). LINK

ホウ素の中性子捕捉反応を利用した低侵襲細胞選択的放射線療法 中村浩之, Yakugaku Zasshi 130, 1687-1694 (2010). LINK

“Selective Inhibition of EGFR and VEGFR2 Tyrosine Kinases Controlled by a Boronic Acid Substituent on 4-Anilinoquinazolines” H. Nakamura, R. Horikoshi, T. Usui, H. S. Ban, Med. Chem. Commun.1, 282-286 (2010). LINK One of the top ten accessed articles from the online version of MedChemComm in the Royal Cemical Society journals!

“Identification of HSP60 as a Primary Target of ortho-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor” H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura, J. Am. Chem. Soc.132(34), 11870-11871 (2010). LINK

リポソームを用いる中性子捕捉治療 上野学、潘鉉承、中村浩之 Drug Delivery System, 25(5), 474-482 (2010). LINK

“Undecahydro-closo-dodecaborates as Good Leaving Groups in Organic Synthesis: Generation of Substituted Styrenes via Elimination of Arylethyl Dodecaborates” A. R. Genady, H. Nakamura, Org. Biomol. Chem. 8, 4427-4435 (2010). LINK

中性子捕捉治療のためのナノカプセル型ホウ素薬剤送達システム(BDS)の開発 中村浩之, Pharm. Tech. Japan (invited) 26, 1005-1012 (2010). LINK

“Discovery of Carboranes as Inducers of 20S Proteasome Activity” H. S. Ban, H. Minegishi, K. Shimizu, M. Maruyama, Y. Yasui, H. Nakamura, ChemMedChem. 5(8), 1236-1241 (2010). LINK

“Synthesis of Triazolyl Methyl-substituted Amino- and Oxy-undecahydrododecaborates for Potential Application in Boron Neutron Capture Therapy” M. E. El-Zaria, A. R. Genady, H. Nakamura, New J. Chem. 34, 1612-1622 (2010). LINK

“Copper(I)-Catalyzed Substitution Reactions of Propargylic Amines: Importance of Csp-Csp3 Bond Cleavage in Generation of Iminium Intermediates” T. Sugiishi, A. Kimura, H. Nakamura, J. Am. Chem. Soc. 132 (15), 5332-5333 (2010). LINK

“Suppression of Hypoxia-induced HIF-1α Accumulation by VEGFR Inhibitors: Different Profiles of AAL993 versus SU5416 and KRN633” H. S. Ban, M. Uno, H. Nakamura, Cancer Lett. 296(1), 17-26 (2010). LINK

“closo-Dodecaborate Lipid Liposomes as New Boron Delivery Vehicles for Neutron Capture Therapy of Cancers” M. Ueno, H. S. Ban, K. Nakai, Y. Kaneda, A. Matsumura, H. Nakamura, Bioorg. Med. Chem. 18, 3059-3065 (2010).

“Boron-Containing Phenoxyacetanilide Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors” K. Shimizu, M. Maruyama, Y. Yasui, H. Minegishi, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 20(4), 1453-1456 (2010). LINK

“Enhancement of EGFR Tyrosine Kinase Inhibition by C-C Multiple Bonds-Containing Anilinoquinazolines” H. S. Ban, Y. Tanaka, W. Nabeyama, M. Hatori, H. Nakamura, Bioorg. Med. Chem. 18(2), 870-879 (2010). LINK

“Boron-Containing Protoporphyrin IX Derivatives and Their Modification for Boron Neutron Capture Therapy: Synthesis, Characterization, and Comparative In Vitro Toxicity Evaluation” M. E. El-Zaria, H. S. Ban, H. Nakamura, Chem. Eur. J. 16(5), 1543-1552 (2010). LINK

2009

“New Strategy for Synthesis of Mercaptoundecahydrododecaborate Derivatives via Click Chemistry: Possible Boron Carriers and Visualization in Cells for Neutron Capture Therapy” M. E. El-Zaria, H. Nakamura, Inorg. Chem. 48(24), 11896-11902 (2009). LINK

“New Types of Potential BNCT Agents, o-Carboranyl Aminoalcohols” C.-H. Lee, G. F. Jin, J. G. Joung, J.-D. Lee, H. S. Ban, H. Nakamura, J.-K. Cho, S. O. Kang, Tetrahedron Lett. 50(24), 2960-2963 (2009). LINK

“Discovery of Boron-Conjugated 4-Anilinoquinazoline as a Prolonged Inhibitor of EGFR Tyrosine Kinase” H. S. Ban, T. Usui, W. Nabeyama, H. Morita, K. Fukuzawa, H. Nakamura, Org. Biomol. Chem. 7 (21), 4415-4427 (2009). LINK

“Synthesis and Biological Evaluation of Boron Peptide Analogues of Belactosin C as Proteasome Inhibitors” H. Nakamura, M. Watanabe, H. S. Ban, A. Asai, Bioorg. Med. Chem. Lett. 19(12), 3220-3224 (2009). LINK

“Discovery of 1-[4-(N-Benzylamino)phenyl]-3-phenylurea Derivatives as a New Class of Hypoxia-Inducible Factor-1α Inhibitors” M. Uno, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 19(12), 3166-3169 (2009). LINK

“Development of Boron Nano Capsules for Neutron Capture Therapy” H. Nakamura, M. Ueno, H. S. Ban, K. Nakai, K. Tsuruta, Y. Kaneda, A. Matsumura, Appl. Radiat. Isotope. 67. S84-S87 (2009). LINK

~2008

“Synthesis and Characterization of o-Carboranylthiolate Substituted 1,3,5-Triazines” C.-H. Lee, G. F. Jin, H.-S. Kim, H. Nakamura, J.-D. Lee, Bull. Korean Chem. Soc. 29(3), 697-700 (2008). LINK

“Preparation of Boronated Heterocyclic Compounds Using Intramolecular Cyclization Reaction” C.-H. Lee, G. F. Jin, H.-S. Kim, H. Nakamura, Y. Chung, J.-D. Lee, Bull. Korean Chem. Soc. 29(2), 357-362 (2008). LINK

“Development of Boron Delivery System for Neutron Capture Therapy of Cancer” H. Nakamura, Progress in Drug Delivery System XVII, 19-24 (2008).

“Synthesis of Allenes via CuBr-catalyzed Homologation of Alk-1-ynes Accelerated by Microwave” H. Nakamura, T. Sugiishi, Y. Tanaka, Tetrahedron Lett. 49(50), 7230-7233 (2008). LINK

“Phase-Vanishing Methods Based on Fluorous Phase Screen. A Simple Way for Efficient Execution of Organic Synthesis” I. Ryu, H. Matsubara, H. Nakamura, D. P. Curran, Chem. Rec. 8(6), 351-363 (2008). LINK

“Molecular Effects of the Tissue-Nonspecific Alkaline Phosphatase Gene Polymorphism (787T>C) Associated with Bone Mineral Density” N. Sogabe, K. Oda, H. Nakamura, H. Orimo, H. Watanabe, T. Hosoi, M. Goseki-Sone, Biomed. Res. 29(4), 213-219 (2008). LINK

がん中性子捕捉療法と次世代ホウ素デリバリーシステム 中村浩之、臨床血液 (invited), 49(5) 294-301 (2008). LINK

“Allene as an Alternative Functional Group for Drug Design: Effect of C-C Multiple Bonds Conjugated with Quinazolines on EGFR Tyrosine Kinase Inhibition” H. S. Ban, S. Onagi, M. Uno, W. Nabeyama, H. Nakamura, ChemMedChem. 3, 1094-1103 (2008). LINK

“Synthesis of closo-Dodecaboryl Lipids and Their Liposomal Formation for Boron Neutron Capture Therapy” H. Nakamura, J.-D. Lee, M. Ueno, Y. Miyajima, H. S. Ban, NanoBiotechnology (invited), 3, 135-145 (2007). LINK

“Synthesis of 1,2-Dihydroisoquinolines via Palladium (0)-Catalysed Addition-Cycloaddition of Pronucleophiles to ortho-Alkynylaldimines” H. Nakamura, H. Saito, M. Nanjo, Tetrahedron Lett. 49, 2697-2700 (2008). LINK

“Synthesis of Mono- and 1,3-Disubstituted Allenes from Propargylic Amines via Palladium-Catalysed Hydride-Transfer Reaction” H. Nakamura, M. Ishikura, T. Sugiishi, T. Kamakura, J-F. Biellmann, Org. Biomol. Chem. 6, 1471-1477 (2008). LINK

“De novo Design and Synthesis of N-Benzylanilines as New Candidates for VEGFR Tyrosine Kinase Inhibitors” M. Uno, H. S. Ban, W. Nabeyama, H. Nakamura, Org. Biomol. Chem. 6, 979-981 (2008). LINK Selected in the RSC’s Chemical Biology Research Articles!

“Liposomal Boron Delivery System for Neutron Capture Therapy” H. Nakamura, YAKUGAKU ZASSHI (Review)128, 193-208 (2008). LINK

“Synthesis and Characterization of Polar Functional Group Substituted Mono- and Bis-(o-carboranyl)-1,3,5-triazine Derivatives” C.-H. Lee, G. F. Jin, J. H. Yoon, Y. J. Jung, J.-D. Lee, S. Cho, H. Nakamura, S. O. Kang, Tetrahedron Lett. 49, 159-164 (2008). LINK

“Discovery of Indenopyrazoles as EGFR and VEGFR-2 Tyrosine Kinase Inhibitors by in silico High-Throughput Screening” T. Usui, H. S. Ban, J. Kawada, T. Hirokawa, H. Nakamura, Bioorg. Med. Chem. Lett.18, 285-288 (2008). LINK

“Synthesis of Dodecaborate-Conjugated Cholesterols for Efficient Boron Delivery in Neutron Capture Therapy” H. Nakamura, M. Ueno, J.-D. Lee, H. S. Ban, E. Justus, P. Fan, D. Gabel, Tetrahedron Lett. 48, 3151-3154 (2007). LINK

“Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy” J.-D. Lee, M. Ueno, Y. Miyajima, H. Nakamura, Org. Lett. 9, 323-326 (2007). LINK

“Synthesis and Liposome Formation of B-10 Enriched B12H11S-Substituted Lipid for Boron Delivery System on BNCT” J-D. Lee, H. Nakamura, Advances in Neutron Capture Therapy, 238-241 (2006).

“Transferrin-Loaded nido-Carborane Liposomes: Synthesis and Intracellular Targeting to Solid Tumors for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, Y. Kuwata, S. Masunaga, K. Ono, K. Maruyama, Advances in Neutron Capture Therapy, 195-198 (2006).

“A New NEDO Reseach Project Toward Hospital Based Accelerator BNCT using Advanced DDS system” A. Matsumura, Y. Mori, Y. Kaneda, K. Hashimoto, K. Nakai, T. Yamamoto, H. Nakamura, K. Akamatsu, T. Asano,S. Lee, Y. Sakurai, H. Kumada, K. Yamamoto, Y. Shibata, T. Shibata, T. Nakahara, M. Mutoh, H. Sakae, Y. Yuasa,Y. Satoh, H. Sakurabata, S. Muraki, T. Nagayama, Advances in Neutron Capture Therapy, 74-76 (2006).

“Selective Inhibition of EGFR and VEGER Tyrosine Kinases Controlled by a Boronic Acid Substituent on 4-Anilinoquinazolines” H. Nakamura, T. Usui, R. Horikoshi, W. Nabeyama, H. S. Ban, YAKUGAKU ZASSHI, 126, 164-165 (2006).

“Synthesis and Biological Evaluation of Benzamides and Benzamidines As Selective Inhibitors of VEGFR Tyrosine Kinases” H. Nakamura, Y. Sasaki, M. Uno, T. Yoshikawa, T. Asano, H. S. Ban, H. Fukazawa, M. Shibuya, Y. Uehara, Bioorg. Med. Chem. Lett. 16, 5127-5131 (2006). LINK

“Transferrin-Loaded nido-Carborane Liposome: Synthesis and Intracellular Targeting to Solid Tumors for Boron Neutron Capture Therapy” Y. Miyajima, H. Nakamura, Y. Kuwata, J-D. Lee, S. Masunaga, K. Ono, K. Maruyama, Bioconjugate Chem. 17, 1310-1320 (2006). LINK Highlighted in the NIH Alliance for Nanotechnology in Cancer, Nanotech, 2006, September 5.

“Synthesis and Biological Evaluation of Boron Containing cis-Stilbenes as Apoptotic Tubulin Polymerization Inhibitors” H. Nakamura, H. Kuroda, H. Saito, R. Suzuki, T. Yamori, K. Maruyama, T. Haga, ChemMedChem 1, 729-740 (2006). LINK

“1,2-Bis(diphenylphosphino)carborane As a Dual Mode Ligand for both the Sonogashira Coupling and Hydride-Transfer Steps in Palladium-Catalyzed One-Pot Synthesis of Allenes from Aryl Iodides” H.Nakamura, T. Kamakura, S. Onagi, Org. Lett. 8, 2095-2098 (2006). LINK

“Synthesis and Biological Evaluation of Allenic Quinazolines Using Palladium-Catalyzed Hydride-Transfer Reaction” H. Nakamura, S. Onagi, Tetrahedron Lett. 47, 2539-2542 (2006). LINK

“Synthesis of Water Soluble THIQ Derivatives as Potential Boron Neutron Capture Therapy Agents: N-Functionalized o-Carboranylmethylbenzopiperidines” C-H. Lee, J. M. Oh, J-D. Lee, H. Nakamura, S. O. Kang, Synlett, 275-278 (2006). LINK

“Synthesis of Ene-Allenes via Palladium-Catalyzed Hydride-Transfer Reaction of Propargylic Amines under Mild Conditions” H. Nakamura, S. Tashiro, T. Kamakura, Tetrahedron Lett. 28, 8333-8336 (2005). LINK

ドッキングシミュレーションによるキナーゼ阻害剤の分子設計 中村浩之, ファルマシア, 最前線, 12月号, 749-753 (2005).

“Transferrin-Conjugated Boron Liposomes as a Potent Boron Delivery System for Neutron Capture Therapy” H. Nakamura, Y. Miyajima, Y. Kuwata, S. Masunaga, K. Ono, K. Maruyama, Progress in Drug Delivery System XIV, 45-53 (2005).

“Synthesis of Hetrocyclic Allenes via Palladium-Catalyzed Hydride-Transfer Reaction of Propargylic Amines” H. Nakamura, S. Onagi, T. Kamakura, J. Org. Chem. 70, 2359-2360 (2005). LINK

“Functional Analysis of the Single-nucleotide Polymorphism (787T>C) in Tissue-nonspecific Alkaline Phosphatase Gene Associated with Born Mineral Density” M. Goseki-Sone, N. Sogabe, M. Fukushi-Irie, L. Mizoi, H. Orimo, T. Suzuki, H. Nakamura, H. Orimo, T. Hosoi, J. Born Miner. Res. 20, 773-782 (2005). LINK

“Synthesis and in vivo biodistribution of BPA-Gd-DTPA Complex as a Potential MRI Contrast Carrier for Neutron Capture Thereapy” K. Takahashi, H. Nakamura, S. Fukumoto, K. Yamamoto, H. Fukuda, A. Matsumura, Y. Yamamoto, Bioorg. Med. Chem. 13, 735-743, (2005). LINK

“trans-1,2-Dibromocyclohexane. The Phase Vanishing Bromination with FC-72 as a Screen Phase” I. Ryu, H. Matsubara, H. Nakamura, D. P. Curran, In The Handbook of Fluorous Chemistry, J. A. Gladysz, D. P. Curran, I. T. Horvath, Eds. Wiley-VCH, Weinheim, (2004). Ch 11.46, pp 468-470. LINK

“Synthesis and Vesicle Formation of a nido-Carborane Cluster Lipid for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka, K. Maruyama, Progress in Drug Delivery System XIII, 85-94 (2004). LINK

“Synthesis of 1,2-dihydroisoquinolines via the reaction of ortho-alkynylarylimines with bis-π-allylpalladium” M. Ohtaka, H. Nakamura, Y. Yamamoto, Tetrahedron Lett. 45, 7339-7341 (2004). LINK

“Synthesis and Vesicle Formation of a nido-Carborane Cluster Lipid for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka, K. Maruyama, Chem. Commun. 1910-1911 (2004). LINK Selected as “Hot Paper” and introduced in the RSC’s Chemical Science, 2004, 1, C65.

“Synthesis of N-Functionalized 3,4-o-Carboranylenepiperidines as Potential Boron Neutron Capture Therapy Agents” C-H. Lee, I. D. Yang, J-D. Lee, H. Nakamura, S-O. Kang, Synlett. 1799-1801 (2004). LINK

“Benzamides and Benzamidines as Specific Inhibitors of Epidermal Growth Factor Receptor and v-Src Protein Tyrosine Kinases” T. Asano, T. Yoshikawa, T. Usui, H. Yamamoto, Y. Yamamoto, Y. Uehara, H. Nakamura, Bioorg. Med. Chem. 12, 3529-3542 (2004). LINK

“Synthesis of Allenes via Palladium-Catalyzed Hydrogen Transfer Reactions: Propargylic Amines As an Allenyl Anion Equivalent” H. Nakamura, T. Kamakura, M. Ishikura, J-F. Biellmann, J. Am. Chem. Soc.126, 5958-5959 (2004).

“Synthesis and Biological Evaluation of Benzamindes and Benzamidines: Structural Requirement of a Pyrimidine Ring for Inhibition of EGFR Tyrosine Kinase” T. Asano, T. Yoshikawa, H. Nakamura, Y. Uehara, Y. Yamamoto, Bioorg. Med. Chem. Lett. 14, 2299-2302 (2004). LINK

“Design, Synthesis, and Biological Evaluation of Aminoboronic Acids as Growth Factor Receptor Inhibitors for EGFR and Flt-1 Tyrosine Kinases” T. Asano, H. Nakamura, Y. Uehara, Y. Yamamoto, ChemBioChem, 5, 483-490 (2004). LINK

“o-Carboranyl Derivatives of 1,3,5-s-Triazines: Structures, Properties, and in vitro Activities” H-G. Lim, J-D. Lee, Y-J. Lee, C-H. Lee, J. Ko, H. Nakamura, S-O. Kang, Appl. Organometal. Chem. 17, 539-548 (2003). LINK

“A Fluorous Solvent as a New Phase-Screen Medium between Reagents and Reactants in the Bromination and Chlorination of Alcohols” H. Nakamura, T. Usui, H. Kuroda, I. Ryu, H. Matsubara, S. Yasuda, D. P. Curran, Org. Lett. 5, 1167-1169 (2003).

“Phase-Vanishing Reactions that Use Fluorous Media as a Phase Screen. Facile, Controlled Bromination of Alkenes by Dibromine and Dealkylation of Aromatic Ethers by Boron Tribromide” I. Ryu, H. Matsubara, S. Yasuda, H. Nakamura, D. P. Curran, J. Am. Chem. Soc. 124, 12946-12947 (2002) LINK

“Tandem Nucleophilic Allylation-Alkoxyallylation of Alkynylaldehydes via Amphiphilic Bis-p-allylapalladium Complexes” H. Nakamura, M. Ohtaka, Y. Yamamoto, Tetrahedron Lett. 43, 7631-7633 (2002). LINK

“A Convenient Synthesis of the Novel carboranyl-substituted Tetrahydroisoquinolines: Application to the Biologically Active Agent for BNCT” J-D. Lee, C-H. Lee, H. Nakamura, J. Ko,S-O.Kang, Tetrahedron Lett. 43, 5483-5486 (2002).

“Palladium-Catalyzed Aminoallylation of Activated Olefins with Allylic Halides and Certain Amines” K. Aoyagi, H. Nakamura, Y. Yamamoto, J. Org. Chem. 67, 5977-5980 (2002). LINK

“Nucleophilic Allylation-Heterocyclization via Bis-p-allylpalladium Complexes: Synthesis of Five- and Six-Membered Heterocycles” Bao, H. Nakamura, A. Inoue, Y. Yamamoto, Chem. Lett. 158-159 (2002). LINK

“o-Carboranyl derivatives of 1,3,5-triazines” H.-G. Lim, J.-D. Lee, Y.-J. Lee, C.-H. Lee, H. Nakamura, S.-H. C.-H. Lee, B. Jun, J. Ko, S.-O. Kang, Research and Development in Neutron Capture Therapy, W. Sauerwein, R. Moss, A. Wittig, Eds. p-37-42, Monduzzi, Bologna (2002).

“Synthesis of carboranyl derivatives of a tetrahydroisoquinoline” J-D. Lee, C-H. Lee, H. Nakamura, S-H. Lee, C-H. Lee, B. Jun, J. Ko, S-O. Kang, Research and Development in Neutron Capture Therapy, W. Sauerwein, R. Moss, A. Wittig, Eds. p-31-35, Monduzzi, Bologna (2002).

“Novel Carboranes with a DNA Binding Unit for the Treatment of Cancer by Boron Neutron Capture Therapy” L.F. Tietze, U. Griesbach, U. Bothe, H. Nakamura, Y. Yamamoto, ChemBioChem, 3, 219-225 (2002).

“Formation of Cyclic Ethers via the Palladium-Catalyzed Cycloaddition of Activated Olefins with Allylic Carbonates Having a Hydroxy Group at the Terminus of the Carbon Chain” M. Sekido, K. Aoyagi, H. Nakamura, C. Kabuto, Y. Yamamoto, J. Org. Chem. 66, 7142-7147 (2001). LINK

“Fluorous Triphasic Reactions: Transportative Deprotection of Fluorous Silyl Ethers with Concomitant Purification” H. Nakamura, B. Linclau, D. P. Curran, J. Am. Chem. Soc. 123, 10119-10120 (2001). LINK

“ortho-Carboranyl Glycosides for the Treatment of Cancer by Boron Neutron Capture Therapy” L. F. Tietze, U. Bothe, U. Griesbach, M. Nakaichi, T. Hasegawa, H. Nakamura, Y. Yamamoto, Bioorg. Med. Chem. 9, 1747-1752 (2001). LINK

“The Fate of Bis-p-allylpalladium Complexes in the Co-existence of Aldehydes (or Imines) and Allylic Chlorides. Stille Coupling versus Allylation of Aldehydes (or Imine)” H . Nakamura, B. Ming, Y. Yamamoto, Angew. Chem. Int. Ed. Engl. 40, 3208-3210 (2001). LINK

“Carboranyl Bisglycosides for the Treatment of Cancer by Boron Neutron Capture Therapy” L. F. Tietze, U. Bothe, U. Griesbach, M. Nakaichi, T. Hasegawa, H. Nakamura, Y. Yamamoto, ChemBioChem, 2, 326-334 (2001). LINK

“Facile Allylative Dearomatization Catalyzed by Palladium” B. Ming, H. Nakamura, Y. Yamamoto, J. Am. Chem. Soc. 123, 759-760 (2001). LINK

“Catalytic Amphiphilic Allylation via Bis-p-allylpalladium Complexes and Its Application to the Synthesis of Medium-Sized Carbocycles” H. Nakamura, K. Aoyagi, J. Shim, Y. Yamamoto, J. Am. Chem. Soc. 123, 372-377 (2001). LINK

“A Concise Synthesis of Chiral L-(4-Boronophenyl)alanine from L-Tyrosine” H. Nakamura, M. Fujiwara, Y. Yamamoto, Frontiers in Neutron Capture Therapy, Eds M. F. Hawthorn, K. Shelly, R. J. Wiersema, p765-768 Kluwer Academic/Plenum Publishers, New York (2001).

“In vitro Uptake Study of 5-Carboranyluridine and Its Derivatives” T. Hasegawa, M. Nakaichi, S. Nakama, H. Nakamura, Y. Yamamoto, M. Takagaki, A. Takeuchi, Frontiers in Neutron Capture Therapy, Eds M. F. Hawthorn, K. Shelly, R. J. Wiersema, p1003-1008 Kluwer Academic/Plenum Publishers, New York (2001).

“In Vivo Evaluation of Carborane Gadolinium-DTPA Complex as an MR Imaging Boron Carrier” H. Nakamura, H. Fukuda, F. Girard, T. Kobayashi, H. Nemoto, J. Cai, K. Yoshida, Y. Yamamoto, Chem. Pharm. Bull. 48, 1034-1038 (2000). LINK

“A Practical Method for the Synthesis of Enantiomerically Pure 4-Borono-L-phenylalanine” H. Nakamura, M. Fujiwara, Y. Yamamoto, Bull. Chem. Soc. Jpn. 73, 231-235 (2000).

“Palladium Catalyzed Cyanoallylation of Activated Olefins” H. Nakamura, H. Shibata, Y. Yamamoto. Tetrahedron Lett. 41, 2911-2914 (2000). PDF file

“Preparation and application of polymer-supported chiral p-allylpalladium catalyst for the allylation of imines” B. Ming, H. Nakamura, Y. Yamamoto, Tetrahedron Lett. 41, 131-134 (2000). LINK

“Palladium(0) Catalyzed Cope Rearrangement of Acyclic 1,5-Dienes. Bis(p-allyl)palladium(II) Intermediate” H. Nakamura, H. Iwama, M. Ito, Y. Yamamoto, J. Am. Chem. Soc. 121 10850-10851(1999). PDF file

“Synthesis of a New Amphiphilic ortho-Carborane Derivative as a Potential BNCT Agent: 4-[N,N-Formyl-(ortho-carboranylmethyl)-amino]-benzoyl-L-glutamic Acid” K.-Y. Rho, Y.-J. Cho, C.-M. Yoon, H. Nakamura, Tetrahedron Lett. 40, 4821-4824 (1999). LINK

“A Concise and Stereospecific One-Shot Synthesis of Bicyclo[3,3,1]nonenols from Dimethyl 1,3-Acetonedicarboxylate and Enals via the Sequential Michael Addition-Intramolecular Aldolization” K. Aoyagi, H. Nakamura, Y. Yamamoto, J. Org. Chem. 64, 4148-4151 (1999). LINK

“Chiral p-Allylpalladium-Catalyzed Asymmetric Allylation: Replacement Allylstannanes by Allylsilanes” K. Nakamura, H. Nakamura, Y. Yamamoto, J. Org. Chem. 64, 2614-2615 (1999). LINK

“Novel Addition Reactions of Silyl- and Stannyl-ortho-carboranes to Carbonyl Compounds” H. Nakamura, Y. Yamamoto, Collect. Czech. Chem. Commun. 64, 829-846 (1999). LINK

“The Synthesis of Carborane Gadolinium-DTPA Complex for Boron Neutron Capture Therapy” H. Nemoto, J. Cai, H. Nakamura, M. Fujiwara, Y. Yamamoto, J. Organomet. Chem. 581, 170-175 (1999). LINK

“Synthetic Utility of o-Carborane: Novel Protective Group for Aldehydes and Ketones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Organomet. Chem. 574, 107-115 (1999). LINK

“Relaxation properties of a dual-labeled probe for MRI and neutron capture therapy” A. T. Tatham, H. Nakamura, E. C. Wiener, Y. Yamamoto, Mag. Res. Med. 42, 32-36 (1999). LINK

“The Renaissance of p-Allylpalladium-catalyzed Organic Synthesis” H. Nakamura, Y. Yamamoto, J. Syn. Org. Chem. Jpn. 56, 395-405(1998).

“Palladium Catalyzed Regioselective b-Acetonation-a-Allylation of Activated Olefins in One Shot” J.-G. Shim, H. Nakamura, Y. Yamamoto, J. Org. Chem. 63, 8470-8474 (1998). LINK

“A Concise Synthesis of Enantiomerically Pure L-(4-Boronophenyl)alanine from L-Tyrosine” H. Nakamura, M. Fujiwara, Y. Yamamoto, J. Org. Chem. 63, 7529-7530 (1998). LINK

“Palladium-Catalyzed Alkoxyallylation of Activated Olefins” H. Nakamura, M. Sekido, M. Ito, Y. Yamamoto, J. Am. Chem. Soc. 120, 6838-6839 (1998). LINK

“Catalytic Asymmetric Allylation of Imines via Chiral Bis-p-allylpalladium Complexes” H. Nakamura, K. Nakamura, Y. Yamamoto, J. Am. Chem. Soc. 120, 4242-4243 (1998). LINK

“Tetrabutylammonium Fluoride Promoted Novel Reactions of o-Carborane: Inter- and Intramolecular Additions to Aldehydes and Ketones and Annulation via Enals and Enones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Am. Chem. Soc. 120, 1167-1171 (1998). LINK

“Amphiphilic Catalytic Allylating Reagent, Bis-p-allylpalladium Complex” H. Nakamura, J-G. Shim, Y. Yamamoto, J. Am. Chem. Soc. 119, 8113-8114 (1997). LINK

“Synthesis of Carboranes Containing Azulene Framework and In vitro Evaluation as Boron Carriers” H. Nakamura, M. Sekido, Y. Yamamoto, J. Med. Chem. 40, 2825-2830 (1997). LINK

“o-Carborane as a Novel Protecting Group of Aldehydes and Ketones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Org. Chem. 62, 780-781 (1997). LINK

“A Novel [3+2] Annulation between o-Carboranyltrimethylsilane and Conjugated Carbonyl Compounds” H. Nakamura, K. Aoyagi, B. Singaram, J. Cai, H. Nemoto, Y. Yamamoto, Angew. Chem. Int. Ed. Engl. 36, 367-369 (1997). LINK

“Tetrabutylammonium Fluoride Promoted Regiospecific Reaction of Trimethylsilyl-o-carborane with Carbonyl Compounds” J. Cai, H. Nemoto, H. Nakamura, B. Singaram, Y. Yamamoto, Advances in Boron Chemistry, Ed. W. Siebert, p112-115, The Royal Society of Chemistry (1997).

“Rat Tumor Imaging with B-10 Carborane Gadolinium Complex” F. Girard, H. Nakamura, H. Fukuda, Y. Yamamoto, K, Yoshida, Recent Advances in Biomedical Imaging, Ed. Y. Ishii et al., p201-207, Elsevier Science (1997).

“Synthesis of Carborane Containing Azlene Framework Using New Palladium Catalyzed Reaction” H. Nakamura, M. Sekido, Y. Yamamoto, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p42-45, Plenum Press, New York (1997).

“MR Imaging of Rat Tumor with 10B Carborane Gadolinium Complex” F. Girard, H. Fukuda, H. Nakamura, Y. Yamamoto, K. Yoshida, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p271-275, Plenum Press, New York (1997).

“A New Synthetic Method of All Carboxylate-free DTPA Derivatives and Its Application to the Synthesis of Gd-Carborane Complex” Y. Yamamoto, J. Cai, H. Nemoto, H. Nakamura, F. Girard, K. Yoshida, H. Fukuda, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p436-439, Plenum Press, New York (1997).

“Tetrabutylammonium Fluoride Promoted Regiospecific Reactions of Trimethylsilyl-o-Carborane with Aldehydes” J. Cai, H. Nemoto, H. Nakamura, B. Singaram, Y. Yamamoto, Chem. Lett. 9, 791-792 (1996).

“Palladium and Platinum Catalyzed Addition of Aldehydes and Imines with Allylstannanes. Chemoselective Allylation of Imines in the Presence of Aldehydes” H. Nakamura, H. Iwama, Y. Yamamoto, J. Am. Chem. Soc. 118, 6641-6647 (1996). LINK

“Unprecedented Highly Chemoselective Allylation of Imines in the Presence of Aldehydes via Palladium Catalyzed Allylstannane Reaction” H. Nakamura, H. Iwama, Y. Yamamoto, Chem. Commun. 1459-1460 (1996). LINK

“Netropsin and Distamycin Analogues Bearing ortho-Carborane” Y. Yamamoto, J. Cai, H. Nakamura, N. Sadayori, H. Nemoto, Cancer Neutron Capture Therapy, Ed. Y. Mishima, 177-182, Plenum Press, New York (1996).

“Palladium and Platinum-catalyzed Addition of Aldehydes with Allylstannanes” H. Nakamura, N. Asao, Y. Yamamoto, J. Chem. Soc. Chem. Commun. 1273-1274 (1995). LINK

“Synthesis of Netropsin and Distamycin Analogues Bearing o-Carborane and Their DNA Recognition” Y. Yamamoto, J. Cai, H. Nakamura, N. Sadayori, N. Asao, H, Nemoto, J. Org. Chem. 60, 3352-3357 (1995).

“Palladium Catalyzed Addition of 1-Carboranyltributyltin to Aldehydes” H. Nakamura, N. Sadayori, M. Sekido, Y. Yamamoto, J. Chem. Soc. Chem. Commun. 22581-2582 (1994).

“Synthesis of New 10B Carriers and Their Selective Uptake by Cancer Cells” Y. Yamamoto, H. Nemoto, H. Nakamura, S. Iwamoto, Current Topics in the Chemistry of Boron Ed. G. Kabalka, p149-154, The Royal Society of Chemistry (1994).

“Synthesis and Biological Properties of Carboranylaziridine” Y. Yamamoto, H. Nakamura, H. Nemoto, Advances in Neutron Capture Therapy, Eds. A.H. Soloway, R.F. Barth, D.E. Carpenter, 305-308, Plenum Press, New York (1993).

“1-Carboranyl-3-methylaziridino-2-propanol. Synthesis, Selective Uptake by B-16 Melanoma, and Selective Cytotoxicity toward Cancer Cells” Y. Yamamoto, H. Nakamura, J. Med. Chem. 36, 2232-2234 (1993).LINK

“Regio- and Stereo-selective Ring Opening of Epoxides with Amide Cuprate Reagents” Y. Yamamoto, N. Asao, M. Meguro, N. Tsukada, H. Nemoto, S. Sadayori, J. Gerald Wilson, H. Nakamura, J. Chem. Soc. Chem. Commun. 1201-1203 (1993). LINK

“Boron-11 NMR of Boron Compounds in the Presence of Cancer Cells” Y. Yamamoto, S. Takamatsu, H. Nakamura, J. Magn. Res. Series B, 101, 198-200 (1993).

“A New Water-soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy” H. Nemoto, S. Iwamoto, H. Nakamura, Y. Yamamoto, Chem. Lett. 465-468 (1993).

“Synthesis of Carboranes Containing Nucleoside Bases” Y. Yamamoto, T. Seko, H. Nakamura, H. Nemoto, Heteroatom Chem. 3, 239-244 (1992). LINK

“Polyols of a Cascade Type as a Water-Solubilizing Element of Carborane Derivatives for Boron Neutron Capture Therapy” H. Nemoto, J. G. Wilson, H. Nakamura, Y. Yamamoto, J. Org. Chem. 57, 435 (1992). LINK

“Synthesis of Carboranes Containing Nucleoside Bases. Unexpectedly High Cytostatic and Cytocidal Toxicity toward Cancer Cells” Y. Yamamoto, T. Seko, H. Nakamura, H. Nemoto, H. Hojo, N. Mukai, Y. Hashimoto, J. Chem. Soc. Chem. Commun. 157-158 (1992).LINK

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