東京工業大学 科学技術創成研究院 化学生命科学研究所 中村・岡田研究室

発表論文

2021202020192018201720162015201420132012201120102009~2008

2021

    1. N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse
      “Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization”, Chemistry Methods, accepted.

    2. K. Umedera, T. Morita, A. Yoshimori, K. Yamada, A. Katoh, H. Koji, H. Nakamura
      “Synthesis of Three-Dimensional (3D) (Di)azatricyclododecene Scaffold and its Application to Peptidomimetics”, Chem. Eur. J.,accepted, DOI:10.1002/chem.202101440

    3. M. Tsuda, T. Morita, H. Nakamura
      “Suzuki-Miyaura Cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles”, Tetrahedron Lett., 75, 153185 (2021), DOI:10.1016/j.tetlet.2021.153185

    4. K. Nakane, S. Sato, T. Niwa, M. Tsushima, S. Tomoshige, H. Taguchi, M. Ishikawa, H. Nakamura
      “Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen”, J. Am. Chem. Soc., 143(20), 7726–7731 (2021), DOI:10.1021/jacs.1c01626

    5. P. Singh, M. Kaur, K. Singh, G. Kaur, R. Meena, M. Kaur, B. Singh, A. Thakur, J. Sharma, A. Singh, M. Kumar, J. H. Yun, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
      “Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy”, Phys. E: Low-Dimens. Syst. Nanostructures, 132, 114766 (2021), DOI:10.1016/j.physe.2021.114766

    6. S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura
      “Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Micro-Flow Reactor”, Chem. Eur. J., 27(27), 7525-7532 (2021), DOI:10.1002/chem.202100059

    7. Y. Asawa, A. V. Arsent’eva, S. A. Anufriev, A. A. Anisimov, K. Y. Suponitsky, O. A. Filippov, H. Nakamura, I. B. Sivaev
      “Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n– 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)”, Molecules, 26(5), 1321 (2021), DOI:10.3390/molecules26051321

    8. 中村 浩之
      「BNCTの薬剤と中性子の反応」、月刊インナービジョン特集号36(2), 40-42 (2021).

    9. M. Tsuda, S. Fukuhara, T. Morita, H. Nakamura
      “Synthesis of 4-Amino-5-allenylisoxazoles via Gold(I)-Catalyzed Propargyl Aza-Claisen Rearrangement”, Org. Biomol. Chem. 19, 1358 (2021), DOI: 10.1039/D0OB02544E

    10. S. Ban, Y. Uto, H. Nakamura
      “Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)”, Expert Opin. Ther. Pat., 31(5), 387-397 (2021), DOI: 10.1080/13543776.2021.1874345

    11. T. Shimizu, N. Takahashi, V. J. Huber, Y. Asawa, H. Ueda, A. Yoshimori, Y. Muramatsu, H. Seimiya, H. Kouji, H. Nakamura, H. Oguri
      “Design and synthesis of skeletally distinct 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α”, Bioorg. Med. Chem., 30, 115949 (2020), DOI:10.1016/j.bmc.2020.115949

    2020

    1. N. Sugisawa, H. Nakamura, S. Fuse
      Recent advances in the continuous-flow reactions using metal-free homogeneous catalysts”, Catalysts 10(11), 1321 (2020); DOI:10.3390/catal10111321.
    2. 北村 宙士、小竹 佑磨、川村 淳、布施 新一郎、中村 浩之
      「入手容易なマイクロミキサーを用いたリポソーム調製法の開発」、製剤機械技術学会誌 29(4), 407-413 (2020).
    3. A. Anufriev, I. B. Sivaev, H. Nakamura
      “Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept”, Phosphorus, Sulfur and Silicon, 195(11) 910-917 (2020), DOI:10.1080/10426507.2020.1804151
    4. S. Yugandar, T. Morita, H. Nakamura
      “Rhodium(III)-Catalyzed Direct C-H Functionalization of Isoxazoles with Alkynes, Alkenes and Sulfoxonium Ylides”, Org. Biomol. Chem. 18, 8625. (2020), DOI:10.1039/D0OB02027C.
    5. K. Kawai, K. Nishimura, S. Okada, S. Sato, M. Suzuki, T. Takata, H. Nakamura
      Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy“, Mol. Pharm. 17(10), 3740 (2020), DOI:10.1021/acs.molpharmaceut.0c00478.
    6. T. Masuzawa, S. Sato, T. Niwa, H. Taguchi, H. Nakamura, T. Oyoshi
      G-Quadruplex-Proximity Protein Labeling Based on Peroxidase Activity, Chem. Commun. 56, 11641 (2020), DOI:10.1039/D0CC02571B.
    7. Y. Asawa, A. Yoshimori, J. Bajorath, H. Nakamura
      Prediction of an MMP-1 Inhibitor Activity Cliff Using the SAR Matrix Approach and Its Experimental Validation, Sci. Rep. 10, 14710 (2020). DOI:10.1038/s41598-020-71696-2.
    8. S. Tanuma, T. Oyama, A. Yoshimori, K. Katsuragi, Y. Shibasaki, Y. Asawa, H. Yamazaki, K. Makino, M. Okazawa, Y. Ogino, Y. Sakamoto, M. Nomura, A. Sato, H. Abe, H. Nakamura, H. Takahashi, N. Tanuma, F. Uchiumi
      Structural insights into the tunnel-shaped cavity of human nicotinamide phosphoribosyltransferase using a close structural set of azacyclohexane-motif inhibitors”,  Molecules, 25(16), 3633 (2020). DOI:10.3390/molecules25163633.
    9. T. Nakagawa, H. Kawashima, T. Morita, H. Nakamura
      Water-soluble closo-Docecaborate-conjugated Pteroyl Derivatives for Boron Neutron Capture Therapy: Evidence of Targeting to Folate Receptor-Mediated Cell Uptake”, Cells, 9(7), 1615 (2020). DOI:10.3390/cells9071615
    10. J. Kawamura, H. Kitamura, Y. Otake, S. Fuse, H. Nakamura
      “Size-Controllable and Scalable Production of Liposomes Using a V-Shape Mixer Micro-Flow Reactor”, Org. Process Res. Dev. 24(10), 2122 (2020), DOI:10.1021/acs.oprd.0c00174.
    11. S. Sato, H. Nakamura
      “Labeling of Peroxidase-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click”, Chem. Pharm. Bull., 68(9), 885-890 (2020). DOI:10.1248/cpb.c20-00434.
    12. M. Tsushima, S. Sato, K. Nakane, H. Nakamura
      “Target protein identification on the photocatalyst-functionalized magnetic affinity beads”, Current Protocols., 101, 1 (2020) (invitation). DOI:10.1002/cpps.108.
    13. G. Li, C. Wang, Y. Li, K. Shao, Wang, X. Guo, W. Zhao, H. Nakamura
      “Zinc (II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylamines with sp and sp3 Carbon Pronucleophiles: Facile Access to Multifunctionalized Tetrahydroquinolines”, Chem. Commun. 56, 7333-7336 (2020). DOI:10.1039/D0CC02921A.
    14. S. Fuse, W. Moriya, S. Sato, H. Nakamura
      “Investigation of detailed influence of acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity”, Bioorg. Med. Chem., 28, 115558 (2020). DOI:10.1016/j.bmc.2020.115558.
    15. S. Sato, K. Nakane, H. Nakamura
      “A Laccase-Catalysed Tyrosine Click Reaction”, Org. Biomol. Chem. 18, 3664 (2020), DOI:10.1039/d0ob00650e.
    16. T. Morita, S. Fuse, H. Nakamura
      “Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines”, Org. Lett., 22(9), 3460-3463 (2020). DOI:10.1021/acs.orglett.0c00910.
    17. Y. Otake, Y. Shibata, Y. Hayashi, S. Kawauchi, H. Nakamura, and S. Fuse
      N-Methylated peptide synthesis via acyl N-methylimidazolium cation generation accelerated by a Brønsted acid”, Angew. Chem. Int. Ed., 59(31), 12925-12930 (2020). DOI:10.1002/anie.202002106
    18. S. Sato, M. Matsumura, T. Kadonosono, S. Abe, T. Ueno, H. Ueda, H. Nakamura
      “Site-Selective Protein Chemical Modification in Exposed Tyrosine Residues Using Tyrosine Click Reaction”, Bioconjugate Chem31(5), 1417-1424 (2020). DOI:10.1021/acs.bioconjchem.0c00120
    19. W. Yimchuen, T. Kadonosono, Y. Ota, S. Sato, M. Kitazawa, T. Shiozawa, T. Kuchimaru, M. Taki, Y. Ito, H. Nakamura, S. Kizaka-Kondoh
      Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold”RSC Advance, 10(26), 15154-15162 (2020). DOI:10.1039/D0RA00427H
    20. N. Sugisawa, H. Nakamura, and S. Fuse
      “Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach”, Chem. Commun., 56, 4527 (2020), DOI:10.1039/d0cc01403f  Selected as a Back Cover Picture
    21. 中村浩之
      「ホウ素中性子捕捉療法:がん細胞内でα線を発生させる次世代放射線治療」 DDS学会誌 35(2), 129-136 (2020). DOI:10.2745/dds.35.129
    22. M. Kaur, P. Singh, R. Meena, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
      “Boron Neutron Capture Therapy Study of 10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line”
      , Journal of Cluster Science, (2020) DOI:10.1007/s10876-020-01773-z.
    23. H.-J. Kim, H.-S. Cho, H. S. Ban, H. Nakamura
      “Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer”, Biochem. Biophys. Res. Commun., 523(3), 726-732 (2020). DOI:10.1016/j.bbrc.2020.01.031.
    24. S. Kikuchi, S. Sato, H. Nakamura
      “Carrier Proteins-Based Boron Delivery to Tumor”, Appl. Radiat. Isotope, 157, 109011-109014 (2020). DOI:10.1016/j.apradiso.2019.109011.
    25. 中村浩之
      「中性子捕捉療法のためホウ素薬剤研究開発の進展-ホウ素薬剤が今後適応疾患拡大の鍵を握る!」 日本原子力学会誌 62(1), 18-22(2020). DOI:10.3327/jaesjb.62.1_18.
    26. S. Fuse, T. Oishi, K. Matsumura, Y. Hayashi, S. Kawauchi, H. Nakamura
      “The design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents”, Org. Biomol. Chem., 18, 93-101 (2020). DOI:10.1039/C9OB02066G.
    27. N. Sugisawa, Y. Otake, H. Nakamura, and S. Fuse
      “Single-step, rapid, and mild synthesis of β-amino acid N-carboxy anhydrides using micro-flow technology”, Chem. Asian J., 15, 79-84 (2020). DOI:10.1002/asia.201901429Selected as an Inside Cover Picture
    28. S. Fuse, K. Suzuki, T. Kuchimaru, T. Kadonosono, H. Ueda, S. Sato, S. Kizaka-Kondo, and H. Nakamura
      “Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity”, Bioorg. Med. Chem.28(1), 115207 (2020). DOI:10.1016/j.bmc.2019.115207.
    29. M. Kumar, P. Singh, K. Singh, U. S. Gaharwar, R. Meena, M. Kumar, F. Nakagawa, S. Wu, M. Suzuki, H. Nakamura, A. Kumar
      “Boron Nitride (10BN) a prospective material for treatment of cancer by Boron Neutron Capture Therapy (BNCT)”, Materials Letters, 259, 126832-126855 (2020). DOI:10.1016/j.matlet.2019.126832.
    30. J.-H. Choy, H. Nakamura, S. Eom, G. Choi
      “2-Dimensional Nanomaterials with Imaging and Diagnostic Functions for Nanomedicine; A Review”, Bull. Chem. Soc. Jpn., 93, 1-12 (2020). DOI:10.1246/bcsj.20190270.

    2019

    1. S. Fuse, K. Masuda, Y. Otake, H. Nakamura
      “Peptide chain elongation using unprotected amino acids in a micro-flow reactor”, Chem. Eur. J., 25(66), 15091-15097 (2019). DOI:10.1002/chem.201903531. Highlighted in Synfacts issue 1/2020, Selected as an Inside Cover Picture
    2. S. Sato, H. Nakamura
      “Protein chemical labeling Using biomimetic radical chemistry”, Molecules, 24(21), 3980 (2019). DOI:10.3390/molecules24213980
    3. M. Tsushima, S. Sato, T. Niwa, H. Taguchi, H. Nakamura
      “Catalyst-Proximity Protein Chemical Labelling on Affinity Beads Targeting Endogenous Lectins.”, Chem. Commun., 55, 13275-13278 (2019). DOI:10.1039/C9CC05231C.
    4. T. Asai, H. Liu, Y. Ozek, S. Sato, T. Hayashi, H. Nakamura
      “Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy”, Appl. Phys. Express, 12(11), 112004 (2019). DOI:10.7567/1882-0786/ab4a5d.
    5. S. Yugandar, H. Nakamura
      “Rhodium(III)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes”, Chem. Commun., 55, 8382-8385 (2019). DOI:10.1039/C9CC03283E. Selected as an Inside Cover Picture
    6. M. Mochizuki, S. Sato, S. Asatyas, Z. J. Leśnikowski, T. Hayashi, H. Nakamura
      “Raman cell imaging with boron cluster molecules conjugated with biomolecules.”, RSC Advances9, 23973-23978 (2019). DOI:10.1039/c9ra04228h.
    7. 佐藤伸一、對馬理彦、中村浩之
      「タンパク質ケミカルラベリングにおける一電子移動反応の活用」 有機合成化学協会誌(特集号2019年5月号「ラジカル種の利用最前線―合成・物性・理論」), 77(5), 463-471 (2019). DOI:10.5059/yukigoseikyokaishi.77.463.
    8. 中村浩之
      「加速器中性子源を用いた中性子捕捉療法の現状と今後の展望」 BIO Clinica, 34(4), 431-434 (2019). LINK
    9. Y. Asawa, K. Katsuragi, A. Sato, A. Yoshimori, S. Tanuma, H. Nakamura
      “Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors”, Bioorg. Med. Chem., 27(13), 2832-2844 (2019). DOI:10.1016/j.bmc.2019.05.013.
    10. S. Ishii, S. Sato, H. Asami, T. Hasegawa, J. Kohno, H. Nakamura
      “Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): Identification of unique modification sites on albumin and investigation of intracellular uptake”, Org. Biomol. Chem., 17, 5496–5499 (2019). DOI:10.1039/C9OB00584F.
    11. S. Sato, M. Yoshida, K. Hatano, M. Matsumura, H. Nakamura
      N’-Acyl-N-methylphenylenediamine as a novel proximity labeling agent for signal amplification in immunohistochemistry”, Bioorg. Med. Chem., 27(6), 1110–1118 (2019). DOI:10.1016/j.bmc.2019.01.036.
    12. S. Fuse, M. Takizawa, S. Sato, S. Okazaki, H. Nakamura
      Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy“, Bioorg. Med. Chem., 27(2), 315–321 (2019). DOI:10.1016/j.bmc.2018.12.006.
    13. T. Kanemitsu, S. Kawabata, M. Fukumura, G. Futamura, R. Hiramatsu, N. Nonoguchi, F. Nakagawa, T. Takata, H. Tanaka, M. Suzuki, S. I. Masunaga, K. Ono, S. I. Miyatake, H. Nakamura, T. Kuroiwa
      “Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats”, Radiat. Environ. Biophys., 58(1), 59–67 (2019). DOI:10.1007/s00411-018-0765-2.

    2018

    1. S. Fukuhara, S. Yugandar, S. Fuse, H. Nakamura
      “Synthesis of 3-hydroxy-4-substituted-picolinonitriles from 4-propargylaminoisoxazoles via stepwise and one-pot isoxazolopyridine formation/N-O bond cleavage sequence”, ACS Omega, 3(12), 16472–16476 (2018). DOI:10.1021/acsomega.8b03114.
    2. S. Fuse, Y. Otake, H. Nakamura
      “Peptide synthesis utilizing micro-flow technology”, Chem. Asian J., 13(24), 3818–3832 (2018). DOI:10.1002/asia.201801488.
    3. I. Fuentes, T. García-Mendiola, S. Sato, M. Pita, H. Nakamura, E. Lorenzo, F. Teixidor, F. Marques, C. Viñas
      “Metallacarboranes on the road to anticancer therapies: cellular uptake, DNA interaction and biological evaluation of cobaltabisdicarbollide ([COSAN])”, Chem. Eur. J., 24(65), 17239-17254 (2018). DOI:10.1002/chem.201803178. Selected as a Front Cover Picture
    4. G. F. Jin, H. S. Ban, H. Nakamura, J.-D. Lee
      “o-Carboranylalkoxy-1,3,5-triazine derivatives: Synthesis, characterization, X-ray structural studies, and biological activity”, Molecules, 23(9), 2194-2207 (2018). DOI:10.3390/molecules23092194.
    5. S. Sato, M. Tsushima, H. Nakamura
      “Target-protein-selective inactivation and labelling using oxidative catalyst”, Org. Biomol. Chem., 16, 6168–6179 (2018). DOI:10.1039/C8OB01484A.
    6. Y. Otake, H. Nakamura, S. Fuse
      “Rapid and mild synthesis of amino acid N-carboxy anhydrides using basic-to-acidic flash switching in a micro-flow reactor”, Angew. Chem. Int. Ed., 57(35), 11389-11393 (2018). DOI:10.1002/anie.201803549. 
    7. 中村浩之
      「中性子捕捉療法(BNCT)におけるホウ素薬剤開発」ファルマシア、54(8), 793-797 (2018). DOI:10.14894/faruawpsj.54.8_793.
    8. S. Fuse, K. Matsumura, M. Takizawa, S. Sato, H. Nakamura
      “The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy”, Bioorg. Med. Chem. Lett., 28(18), 3099-3104 (2018). DOI:10.1016/j.bmcl.2018.07.025.

    9. 中村浩之
      「医薬品におけるホウ素化合物の化学 特集「新・元素物語 ホウ素」」月刊化学、73(8), 37-40 (2018). LINK
    10. S. Sato, K. Hatano, M. Tsushima, H. Nakamura
      “1-Methyl-4-aryl-urazole (MAUra) Labels Tyrosine in Proximity to Ruthenium Photocatalyst”, Chem. Commun.54, 5871-5874 (2018). DOI:10.1016/j.bmcl.2018.07.025.
    11. H. Ueda, A. Yoshimori, H. Nakamura
      “Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors”, Bioorg. Med. Chem., 26(12), 3345-3351(2018). DOI:10.1016/j.bmc.2018.05.002

    12. Y. Otake, H. Nakamura, S. Fuse
      “Recent advances in the integrated micro-flow synthesis containing photochemical reactions”, Tetrahedron Lett., 59(18), 1691-1697 (2018). DOI:10.1016/j.tetlet.2018.03.019Selected as a Front Cover Picture
    13. S. Ishii, H. Nakamura
      “Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy”, J. Organomet. Chem., 865, 178-182 (2018). DOI:10.1016/j.jorganchem.2018.02.026.
    14. T. Morita, S. Yugandar, S. Fuse, H. Nakamura
      “Recent progresses in the synthesis of functionalized isoxazoles”,
      Tetrahedron Lett., 59(13), 1159-1171 (2018). DOI:10.1016/j.jorganchem.2018.02.026.
    15. H. Nakamura, S. Kikuchi, K. Kawai, S. Ishii, S. Sato
      “closo-Dodecaborate-conjugated human serum albumins: preparation and in vivo selective boron delivery to tumor”, Pure Appl. Chem., 90(4), 745-753 (2018). DOI:10.1515/pac-2017-1104.
    16. Zeng, Y. Mizuno, K. Nakamura, S. Fuse, H. Nakamura
      ”Compact test set for sensitivity evaluation of photoacoustic contrast agent”, Acoust. Sci. Technol., 39(3), 259-262 (2018). DOI:10.1250/ast.39.259

    17. 中村浩之
      「血清アルブミンを利用したホウ素デリバリーシステム」BIO Clinica, 33(2), 2-5 (2018). LINK
    18. S. Fuse, M. Inaba, S. Sato, M. Joshi, H. Nakamura
      “Synthesis of pyrazolofuropyrazine via one-pot SNAr reaction/intramolecular C-H direct arylation”, Synthesis, 50(7), 1493-1498 (2018). DOI:10.1055/s-0036-1591885.
    19. T. Morita, S. Fukuhara, S. Fuse, H. Nakamura
      “Gold(I)-catalyzed intramolecular SEAr reaction: Efficient synthesis of isoxazole-containing fused heterocycles”, Org. Lett., 20(2), 433–436 (2018). DOI:10.1021/acs.orglett.7b03760. Highlighted in Synfacts issue 4/2018
    20. S. Sato, M. Tsushima, K. Nakamura, H. Nakamura
      “Development and application of catalytic tyrosine modification”, Yakugaku Zasshi, 138(1), 39-46 (2018). DOI:10.1248/yakushi.17-00186-1.
    21. 中村浩之
      「血清アルブミンを利用したホウ素デリバリーシステム」月刊 細胞 50(1), 37-40 (2018). LINK
    22. H. Masui, M. M. Maitani, S. Fuse, A. Yamamura, Y. Ogomi, S. Hayase, T. Kaiho, H. Tanaka, Y. Wada, and T. Takahashi
      “D–π–A dyes containing novel hydantoin anchoring groups for dye-sensitized solar cells”, Asian J. Org. Chem., 7(2), 458-464 (2018). DOI:10.1002/ajoc.201700542.

    2017

    1. 布施新一郎、田中浩士、高橋孝志、土井隆行「マンノペプチマイシンアグリコンの合成と立体配置訂正」、有機合成化学協会誌、75(12), 1274-1285 (2017). DOI:10.5059/yukigoseikyokaishi.75.1274
    2. 中村浩之「「展望」中性子捕捉療法のための新しいホウ素薬剤の開発 ─血清アルブミンホウ素キャリア─」Isotope News 753(10), 2-7 (2017). LINK
    3. M. Inai, N. Honda, H. Hazama, S. Akter, S. Fuse, H. Nakamura, T. Nishikawa, Y. Kaneda, K. Awazu “Photodynamic therapy using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane“, Photodiag. Photodyn. Ther., 20, 238-245 (2017). DOI:10.1016/j.pdpdt.2017.10.017.
    4. S. Fuse, M. Takizawa, K. Matsumura, S. Sato, S. Okazaki, H. Nakamura “Thiophene-based, Organic D-π-A dyes as Potent Sensitizers for Photodynamic Therapy”, Eur. J. Org. Chem., 34, 5170–5177 (2017). DOI:10.1002/ejoc.201701019.
    5. 布施新一郎「チオフェン含有有機Donor-π-Acceptor色素の系統的合成と構造-機能相関解明」、有機合成化学協会誌、75(9), 941-954 (2017). DOI:10.5059/yukigoseikyokaishi.75.941.
    6. S. Sato, S. Ishii, H. Nakamura “Development of Albumin-closo-Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3-Photocatalyzed Modification of Tyrosine”, Eur. J. Inorg., 38(39), 4406-4410 (2017). DOI:10.1002/ejic.201700578. Selected as a Front Cover Picture
    7. 中村浩之「血清アルブミンを利用したホウ素デリバリーシステム」、BIO Clinica, 32(7), 669-703 (2017). LINK
    8. M. Inai, N. Honda, H. Hazama, H. Nakamura, H. Yasuda, T. Nishikawa, Y. Kaneda, K. Awazu “Subcellular localization of novel photosensitizer named porphyrus envelope in human prostate cancer cell line PC-3”, JJSLSM, 37(4), 415-420 (2017). DOI: 10.2530/jslsm.jslsm-37_0028
    9. S. Fuse, Y. Otake, H. Nakamura “Integrated Micro-flow Synthesis Based on Photochemical Wolff Rearrangement” (micro review)  Eur. J. Org. Chem., 44, 6466, (2017). DOI:10.1002/ejoc.201700789.
    10. M. Tsushima, S. Sato, H. Nakamura “Selective Purification and Chemical Labeling of Target Protein on Ruthenium Photocatalyst-Immobilized Affinity Beads” Chem. Commun., 53, 4838-4841 (2017). DOI:10.1039/C7CC01595J.
    11. W. Nabeyama, K. Ishihara, H. S. Ban, H. Wada, H. Nakamura “Discovery of (2-Aminophenyl)methanol as a New Molecular Chaperone That Rescues the Localization of P123S Mutant Pendrin Stably Expressed in HEK293 Cells”, Bioorg. Med. Chem., 25(9), 2601–2608 (2017). DOI:10.1016/j.bmc.2017.03.024.
    12. S. Fuse, T. Morita, H. Nakamura “Step-by-Step Multifunctionalization of Isoxazoles based on SEAr Reactions and C-H Direct Arylations.” (short review), Synthesis, 49(11), 2351-2360 (2017). DOI:10.1055/s-0036-1588784.
    13. H. Masui, S. Yosugi, S. Fuse, T. Takahashi “Solution-phase automated synthesis of α-amino aldehyde as a versatile intermediate”, Beilstein J. Org. Chem., 13, 106-110 (2017). DOI:10.3762/bjoc.13.13.
    14. S. Sato, K. Nakamura, H. Nakamura “Horseradish-Peroxidase-Catalyzed Tyrosine Click Reaction”, ChemBioChem.18(5), 475–478 (2017). DOI:10.1002/cbic.201600649.

    2016

    1. G. Dormán, H. Nakamura, A. Pulsipher, G. D. Prestwich “The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore”, Chem. Rev., 116(24), 15284–15398 (2016). DOI:10.1021/acs.chemrev.6b00342.
    2. M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu “Effective Photodynamic Therapy in Drug-resistant Prostate Cancer Cells Utilizing a Non-viral Antitumor Vector (a secondary publication)”, Laser therapy, 25(1), 55-62 (2016). DOI:10.5978/islsm.16-OR-05.
    3. Y. Mifune, H. Nakamura, S. Fuse “A Rapid and Clean Synthetic Approach to Cyclic Peptides via Micro-flow Peptide Chain Elongation and Photochemical Cyclization: Synthesis of a Cyclic RGD Peptide”, Org. Biomol. Chem., 14(47), 11244-11249 (2016). DOI:10.1039/C6OB02391F.
    4. S. Fuse, T. Ohuchi, Y. Asawa, S. Sato, H. Nakamura “Development of 1-Aryl-3-furanyl/Thienyl-imidazopyridine Templates for Inhibitors against Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity”, Bioorg. Med. Chem. Lett., 26(24), 5887–5890 (2016). DOI:10.1016/j.bmcl.2016.11.009.
    5. S. Fuse, Y. Mifune, H. Nakamura, H. Tanaka “Total Synthesis of Feglymycin based on a Linear/Convergent Hybrid Approach using Micro-flow Amide Bond Formation”, Nat. Commun., 7, 13491 (2016). DOI:10.1038/ncomms13491.
    6. S. Fuse, K. Matsumura, K. Johmoto, H. Uekusa, H. Tanaka, T. Hirose, T. Sunazuka, S. Ōmura, T. Takahashi “The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-pyridyl-xanthones for Use as Insecticides Starting from Pyripyropene A”, Chem. Eur. J., 22(51), 18450-18455 (2016). DOI:10.1002/chem.201603980. Selected as a Hot Paper
    7. T. Morita, S. Fuse, H. Nakamura “Generation of 4-Isoxazolyl Anion Species: Facile Access to 4-Substituted Isoxazoles”, Angew. Chem. Int. Ed., 55(43), 13580-13584 (2016). DOI:10.1002/anie.201608039. Highlighted in Synfacts issue 12/2016
    8. S. Kikuchi, D. Kanoh, S. Sato, Y. Sakurai, M. Suzuki, H. Nakamura “Maleimide-Functionalized closo-Dodecaborate Albumin Conjugates (MID-AC): The Unique Ligation at both Cysteine and Lysine Residues Enabling to Efficient Boron Delivery to Tumor for Neutron Capture Therapy”, J. Control. Release, 237160–167 (2016). DOI:10.1016/j.jconrel.2016.07.017.
    9. N. Shiraishi, M. Kumazoe, S. Fuse, H. Tachibana, H. Tanaka “The Synthesis of trans-Flavan-3-ol Gallates by Regioselective Oxidative Etherification and Their Biological Evaluation” Chem. Eur. J.22(37), 13050-13053 (2016). DOI:10.1002/chem.201602817.
    10. G. Li, H. Nakamura “Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles”, Angew. Chem. Int. Ed., 55(23), 6758-6761 (2016). DOI:10.1002/anie.201602416. 
    11. H. Hamagami, M. Kumazoe, Y. Yamaguchi, S. Fuse, H. Tachibana, H. Tanaka “6-Azido-6-deoxy-L-idose as a Hetero-bifunctional Spacer for the Synthesis of Azido-containing Chemical Probes”, Chem. Eur. J., 22(36), 12884-12890 (2016). DOI:10.1002/chem.201602044.
    12. R. Suzuki, S. Fuse, H. Tanaka “Synthesis of Asymmetrically Terminal Bifunctionlized Alkanes by Sequential Suzuki-Miyaura Coupling using B-Thexyl Boracyclanes”, Eur. J. Org. Chem., 21, 3478–3481 (2016). DOI:10.1002/ejoc.201600392.
    13. S. Ban, Y. Uto, M. Won, H. Nakamura “Hypoxia-Inducible Factor Inhibitors: A Patent Review (2011-2015)”, Exp. Opin. Ther. Pat., 26(3), 309–322 (2016). DOI:10.1517/13543776.2016.1146252.
    14. M. Sasai, H. Nakamura, N. Sougawa, Y. Sakurai, M. Suzuki, A. Matsuyama, C. M. Lee “Novel Hyaluronan Formulation Enhances the Efficacy of Boron Neutron Capture Therapy for Murine Mesothelioma”, Anticancer Res., 36(3), 907-911 (2016).  LINK
    15. T. Aoyagi, S. Ohira, S. Fuse J. Uzawa, Y. Yamaguchi, H. Tanaka “The α-Glycosidation of Partially Unprotected N-Acetyl and N-Glycolyl Sialyl Donors in the Absence of a Nitrile Solvent Effect”, Chem. Eur. J., 22(20), 6968-6973 (2016). DOI:10.1002/chem.201601031.
    16. S. Irie, S. Fuse, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, H. Masui, H. Tanaka, T. Takahashi “Rapid Synthesis of D-A’-π-A Dyes via One-Pot Three-Component Suzuki-Miyaura Coupling and an Evaluation of the Photovoltaic Properties for Use in DSSCs”, Chem. Eur. J.22(7), 2507-2514 (2016). DOI:10.1002/chem.201504277.
    17. S. Fuse, R. Takahashi, M. M. Maitani, Y. Wada, T. Kaiho, H. Tanaka, T. Takahashi “Synthesis and Evaluation of Thiophene-based Organic Dyes Containing a Rigid and Non-Planar Donor with Secondary Electron Donors for Use in Dye-Sensitized Solar Cells”, Eur. J. Org. Chem., 3, 508-517 (2016). DOI:10.1002/ejoc.201501190.

    2015

    1. A. Sato, T. Itoh, S. Imamichi, S. Kikuhara, H. Fujimori, T. Hirai, S. Saito, Y. Sakurai, H. Tanaka, H. Nakamura, M. Suzuki, Y. Murakami, D. Baiseitov, K. Berikkhanova, Z. Zhumadilov, Y. Imahori, J. Itami, K. Ono, S. Masunaga, M. Masutani
      “Proteomic Analysis of Cellular Response Induced by Boron Neutron Capture Reaction in Human Squamous Cell Carcinoma SAS Cells”, Appl. Radiat. Isotope, 106, 213-219 (2015). DOI:10.1016/j.apradiso.2015.08.001
    2. S. Tachikawa, S. Sato, H. Hazama, Y. Kaneda, K. Awazu, H. Nakamura
      “Localization-Dependent Cell-Killing Effects of Protoporphyrin (PPIX)-Lipid Micelles and Liposomes in Photodynamic Therapy”, Bioorg. Med. Chem., 23(24), 7578-7584 (2015). DOI:10.1016/j.bmc.2015.11.001.
    3. 増井悠、布施新一郎、高橋孝志
      「ワンポット多成分連結反応を基盤とした機能性分子のコンビナトリアル合成」Organometallic News,  3, 100-104 (2015). 
    4. S. Sato, K. Nakamura, H. Nakamura
      “Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives”, ACS Chem. Biol., 10(11), 2633-2640 (2015). DOI:10.1021/acschembio.5b00440
    5. 布施新一郎
      「サイト選択的マイクロフロー反応を駆使する天然物合成」 化学と工業 68(8), 733-734 (2015). 
    6. S. Fuse, Y. Otake, Y. Mifune, H. Tanaka
      “A Facile Preparation of α-Aryl Carboxylic Acid via One-flow Arndt-Eistert Synthesis”, Aust. J. Chem., (invited)  68(11), 1657-1661 (2015). DOI:10.1071/CH15342
    7. S. Fuse, T. Morita, K. Johmoto, H. Uekusa, H. Tanaka
      “Directing Group/Protecting Group-Free Synthesis of Tetraaryl-Substituted Pyrazoles via Four Direct Arylations on an Unsubstituted Pyrazole Scaffold”, Chem. Eur. J., 21(41), 14370-14375 (2015). DOI:10.1002/chem.201502399Selected as an Inside Cover Picture, Selected as a Hot Paper
    8. H. Koganei, S. Tachikawa, M. E. El-Zaria, H. Nakamura
      “Synthesis of Oligo-closo-dodecaborates by Hüisgen Click Reaction as Encapsulated Agents for Preparation of High-Boron-Content Liposomes for Neutron Capture Therapy”, New J. Chem., 39, 6388-6394 (2015). DOI:10.1039/C5NJ00856E.
    9. H. Masui, N. Ishizawa, S. Fuse, T. Takahashi
      “Palladium-Catalyzed Double Carbonylation-Based Diversity-Oriented Synthesis of 3,4-Dihydroisoquinoline-1-Carboxamides”, Tetrahedron, 71(37), 6354-6360 (2015). DOI:10.1016/j.tet.2015.05.102
    10. G. Li, S. Azuma, H. Minegishi, H. Nakamura
      “Synthesis and Biological Evaluation of meta-Carborane-Containing phenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1”, J. Organomet. Chem., 798(1), 189-195 (2015). DOI:10.1016/j.jorganchem.2015.05.029.
    11. S. Fuse, H. Sugiyama, D. Kobayashi, Y. Iijima, K. Matsumura, H. Tanaka, T. Takahashi
      “Regio-Selective, One-pot, Three-component Synthesis of 1,3,4- and 1,3,5-Triaryl Pyrazoles from 1- and 2-Aryl-1-Alkenyl Sulfones”, Eur. J. Org. Chem., 21, 4756-4764 (2015). DOI:10.1002/ejoc.201500562
    12. T. Morita, D. Kobayashi, K. Matsumura, K. Johmoto, H. Uekusa, S. Fuse, T. Takahashi
      “Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles”, Chem. Asian J., 10(8), 1626-1630 (2015). DOI:10.1002/asia.201500362 Selected as a Front Cover Picture, Selected as Wiley Hottest Articles in Organic Chemistry
    13. 布施新一郎、高橋孝志
      「マイクロフロー光反応・イミドイル化反応・アシル化反応を駆使する効率的な有機合成」有機合成化学協会誌、73(5), 442-451 (2015). DOI:10.5059/yukigoseikyokaishi.73.442.
    14. S. Fuse, A. Ikebe, K. Oosumi, T. Karasawa, K. Matsumura, M. Izumikawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Doi, T. Takahashi
      “Asymmetric Total Synthesis of ent-Pyripyropene A”, Chem. Eur. J., 21(26), 9454-9460 (2015). DOI:10.1002/chem.201500703
    15. K. Matsumura, S. Yoshizaki, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, S. Fuse, H. Tanaka, T. Takahashi
      “Rapid Synthesis of Thiophene-Based, Organic Dyes for DSSCs via a One-Pot, Four-Component Coupling Approach”, Chem. Eur. J.21(27), 9742-9747 (2015). DOI:10.1002/chem.201500979.
    16. S. Fuse, R. Takahashi, T. Takahashi
      “Facile, One-Step Synthesis of 5-Substituted Thieno[3,4-c]pyrrole-4,6-dione by Palladium-Catalyzed Carbonylative Amidation”, Eur. J. Org. Chem., 16, 3430-3434 (2015). DOI:10.1002/ejoc.201500273.
    17. 山内将哉、本多典広、間久直、立川将士、中村浩之、金田安史、粟津邦男
      「抗腫瘍効果を持つ非ウイルスベクター用いた薬剤耐性前立腺がん細胞に対する高効率な光線力学療法」レーザー医学会 36(1), 18-24 (2015). DOI:10.2530/jslsm.jslsm-36_0002
    18. G. Li, S. Azuma, S. Sato, H. Minegishi, H. Nakamura
      “ortho-Carboranylphenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1Transcriptional Activity and Heat Shock Protein (HSP) 60 Chaperon Activity”, Bioorg. Med. Chem. Lett., 25(13), 2524-2628 (2015). DOI:10.1016/j.bmcl.2015.04.088.
    19. H. Minegishi, Y. Futamura, S. Fukashiro, M. Muroi, M. Kawatani, H. Osada, H. Nakamura
      “Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods”, J. Med. Chem., 58(10), 4230-4241 (2015). DOI:10.1021/acs.jmedchem.5b00035
    20. H. Nakamura
      “C(sp3)–H versus C(sp3)–C(sp) in Activation of Propargylic Amines under Transition-Metal Catalysis”, Synlett26(12), 1649-1664 (2015). DOI:10.1055/s-0034-1380462.
    21. H. S. Ban and H. Nakamura
      “Boron-Based Drug Design”, Chem. Rec., 15(3), 616-635 (2015). DOI:10.1002/tcr.201402100.
    22. S. Sato, K. Morita, H. Nakamura
      “Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst”, Bioconjugate Chem., 26(2), 250-256 (2015). DOI:10.1021/bc500518t.
    23. H. Nakamura, L. Tazaki, D. Kanoh, S. Sato
      “Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity”, Pure Appl. Chem., 87(2), 145-154 (2015). DOI:10.1515/pac-2014-0911.
    24. H. Nakamura, H. Koganei, T. Miyoshi, Y. Sakurai, K. Ono, M. Suzuki
      “Antitumor Effect of Boron Nitride Nanotubes in Combination with Thermal Neutron Irradiation on BNCT”, Bioorg. Med. Chem. Lett., 25(2), 172-174 (2015). DOI:10.1016/j.bmcl.2014.12.005.
    25. 中村浩之
      「ホウ素化合物・薬剤の歴史と現状」 RADIOISOTOPES, 64(1), 47-58 (2015). DOI:10.3769/radioisotopes.64.47.

    2014

    10. 薬剤耐性前立腺がん細胞への PDTの検討 =非ウィルスベクターとPpIX脂質を用いた新規光感受性薬剤の開発= 粟津邦男、金田安史、山内将哉、中村浩之 月刊 光アライアンス 特集号「がんを抑え込む光線治療」25(9), 17-22 (2014).

    9. がん光線力学療法のためのDDS薬剤の開発:ポルフィリン脂質の開発とナノキャリアへの応用 立川将士、中村浩之 月刊 光アライアンス 特集号「がんを抑え込む光線治療《25(9), 12-16 (2014).

    8. “Spermidinium Closo-dodecaborate-encapsulating Liposomes as Efficient Boron Delivery Vehicles for Neutron Capture Therapy” S. Tachikawa, T. Miyoshi, H. Koganei, M. E. El-Zaria, C. Viñas, M. Suzuki, K. Ono, H. Nakamura, Chem. Commun. 50(82), 12325-12328 (2014). LINK(open access)

    7. “Protoporphyrin-Lipids: Their Synthesis, Liposomal Formation and Efficient Delivery to Tumor” S. Tachikawa, M. E. El-Zaria, R. Inomata, S. Sato, H. Nakamura, Bioorg. Med. Chem. 22(17) 4745–4751 (2014). LINK

    6. “Design of Photoaffinity Probe Molecules for Identification and Modification of Target Proteins” H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, S. Sato, J. Photopolym. Sci. Technol. 27(4) 453-458 (2014). LINK

    5. “V843I, a Lung Cancer Predisposing EGFR Mutation, is Responsible for Resistance to EGFR Tyrosine Kinase Inhibitors” S. Matsushima, K. Ohtsuka, H. Ohnishi, M. Fujiwara, H. Nakamura, T. Morii, H. Goto, T. Watanabe, J. Thor. Oncol. 9(9) 1377-1384 (2014). LINK

    4. “Reactivity of Propargylic Amines in the Presence of Transition Metals” T. Sugiishi, H. Nakamura, J. Syn. Org. Chem. 72, 654-665 (2014).

    3. “Amphiphilic COSAN and I2-COSAN Crossing Synthetic Lipid Membranes: Planar Bilayers and Liposomes” C. Verdia-Baguena, A. Alcaraz, V. M. Aguilella, A. M. Cioran, S. Tachikawa, H. Nakamura, F. Teixidor, Clara. Vinas, Chem. Commun. 50, 6700-6703 (2014). LINK

    2. “Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors” H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, H. H. Ban, J. Chem. Soc., Dalton Trans. (invited), 43(13), 4941-4944 (2014). LINK

    1. “A novel photodynamic therapy for drug resistant prostate cancer cells using porphyrus Envelope as a novel photosensitizer” M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu, Photodiag. Photodynam. Ther. 11(1), 48-54 (2014). LINK

    2013

    10. “Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy” H. Nakamura, Yakugaku Zasshi (Review), 133(12), 1297-1306 (2013). LINK

    9. “Ligand-directed Selective Protein Modification Based on Local Single Electron Transfer Catalysis” S. Sato, H. Nakamura, Angew. Chem. Int. Ed. 52, 8681-8684 (2013). LINK

    8. “Synthesis and Biological Evaluation of ortho-Carborane Containing Benzoxazole as an Inhibitor of Hypoxia Inducible Factor (HIF)-1Transcriptional Activity” H. Nakamura, Y. Yasui, H. S. Ban, J. Organomet. Chem. (special issue) 747, 189-194 (2013). LINK

    7. “Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors” H. Minegishi, S. Fukashiro, H. S. Ban, H. Nakamura, ACS Med. Chem. Lett. 4, 297-301 (2013). LINK

    6. “Boron Cluster Lipid Liposomes as New Vehicles for Boron Delivery System of Neutron Capture Therapy” H. Nakamura, Future Med. Chem. (invited) 5(6), 715-730(2013). LINK

    5. “Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their cholesterol conjugates” M. Bialek-Pietras, A. B. Olejniczak, S. Tachikawa, H. Nakamura, Z. J. Lesnikowski, Bioorg. Med. Chem. 21, 1136-1142 (2013). LINK

    4. “Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity” H. Minegishi, T. Matsukawa, H. Nakamura, ChemMedChem. 8, 265-271 (2013). LINK Selected as an Inside Cover Picture

    3. “Development of Hypoxia-Inducible Factor (HIF)-1α Inhibitors: Effect of ortho-Carborane Substituents on HIF Transcriptional -Activity under Hypoxia” H. Nakamura, Y. Yasui, M. Maruyama, H. Minegishi, H. S. Ban, S. Sato, Bioorg. Med. Chem. Lett. 23, 1455-1461 (2013). LINK

    2. “Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers” H. Koganei, M. Ueno, S. Tachikawa, L. Tasaki, H. S. Ban, M. Suzuki, K. Shiraishi, K. Kawano, M. Yokoyama, Y. Maitani, K. Ono, H. Nakamura, Bioconjugate Chem. 24, 124-132 (2013). LINK

    1. “HSP60 as a drug target” H. Nakamura, H. Minegishi, Curr. Pharm. Des. (Review) 19(3), 441-451 (2013). LINK

    2012

    9. 蛍光標識ホウ素脂質の開発とリポソーム化による細胞内イメージング 上田記子、小金井逸人、上野学、立川将士、鈴木実、小野公二、中村浩之、 Progress in Drug Delivery System XXI, 68-73 (2012).

    8. “Synthesis and Biological Evaluation of Furylindazoles as Hypoxia Inducible Factor (HIF)-1α Inhibitors” A. Takeuchi, M. Hori, S. Sato, H. S. Ban, T. Kuchimaru, S. Kizaka-Kondoh, T. Yamori, H. Nakamura, Med. Chem. Commun. 3, 1455-1461 (2012). LINK

    7. “Discovery of 1-[4-(N-Benzylamino)phenyl]-3-phenylurea Derivatives as Non-Peptidic Selective SUMO-Sentrin Specific Protease (SENP)1 Inhibitors” M. Uno, Y. Koma, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 22, 5169-5173 (2012). LINK

    6. “Copper(I)-catalysed Deacetylenative Cross-coupling Reaction of Terminal Alkynes with Propargylic Amines via C(sp)-C(sp3) Bond Cleavage” Y. Kim, H. Nakamura, Synlett. 23, 1686-1690 (2012). LINK

    5. “In vitro Investigation of Efficient Photodynamic Therapy Using Non-viral Vector; Hemagglutinating Virus of Japan Envelope” N. Fujimoto, M. Sakai, K. Ishii, H. Nakamura, Y. Kaneda, K. Awazu, J. Biomed. Opt. 17(7), 078002 (Jul 17, 2012). LINK

    4. “Identification of Heat Shock Protein 60 as the Regulator of the Hypoxia-inducible Factor Sub-unit HIF-1α” H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura, Pure Appl. Chem. 84(11), 2325-2337 (2012). LINK

    3. “Synthesis and Biological Evaluation of Boronic Acid Containing Phenstatin Analogues” H. Nakamura, H. Kuroda, H. Minegishi, ARKIVOC. (2012)(vii), 79-87. LINK

    2. “Zinc(II)-Catalyzed Redox Cross-Dehydrogenative Coupling of Propargylic Amines and Terminal Alkynes for Synthesis of N-Tethered 1,6-Enynes” T. Sugiishi, H. Nakamura, J. Am. Chem. Soc. 134, 2504-2507 (2012). LINK

    1. “Design and Synthesis of Fluorescence-labeled Closo-dodecaborate Lipid: Liposome Formation and in vitro and in vivo Imaging Targeting to Tumor for Boron Neutron Capture Therapy” H. Nakamura, N. Ueda, H. B. Ban, M. Ueno, S. Tachikawa, Org. Biomol. Chem. 10, 1374-1380 (2012). LINK

    2011

    9. 今後、治療の多様化に適応できるホウ素薬剤の開発を 中村浩之, エネルギーレビュー, 特集:岐路に立つホウ素中性子捕捉療法, 31(11), 17-18 (2011). LINK

    8. cile Synthesis of 4-Substituted 3,4-Dihydro-1H-2,1,3-Benzothiadiazine 2,2-Dioxides” C.-H Lee, G. F. Jin, H. W. Lim, E. H. Yang, J.-D. Lee, H. Nakamura, H. S. Ban, S. O. Kang, Heteroatom Chem. 22, 192-197 (2011). LINK

    7. “Copper(I)-catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes” Y. Kim, H. Nakamura, Chem. Eur. J. 17, 12561-12563 (2011). LINK

    6. scovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors” H. Nakamura, A. Shoji, A. Takeuchi, H. B. Ban, J.-D. Lee, T. Yamori, S. O. Kang, Aust. J. Chem. 64 (11), 1430-1437 (2011). LINK

    5. “Amphiphilic Allylation of Arylidene-1,3-oxazol-5(4H)-one Using Bis-π-allylpalladium Complexes: An Approach to Synthesis of Cyclohexyl and Cyclohexenyl α-Amino Acid” A. R. Genady, H. Nakamura, Org. Biomol. Chem. 9, 7180-7189 (2011). LINK

    4. “Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers” Y. Ito, T. Mizuno, K. Yoshino, H.S. Ban, H. Nakamura, J. Hiratsuka, A. Ishikawa, H. Ohki, Appl. Radiat. Isotope. 69(12), 1771-1773 (2011). LINK

    3. “m-Carborane-Based Chiral NBN Pincer-Metal Complexes: Synthesis, Structure, and Application in Asymmetric Catalysis” M. E. El-Zaria, H. Arii, H. Nakamura, Inorg. Chem. 50(9), 4149-4161(2011). LINK

    2. “Hypoxia-Inducible Factor Inhibitors: A Survey of Recent Patented Compounds (2004-2010)” H. S. Ban, Y. Uto, H. Nakamura, Exp. Opin. Ther. Patents, (invited)21(2), 131-146 (2011). LINK

    1. “Catalytic Reactions of Bis-π-allylpalladium Generated from Allyltrifluoroborate” H. Nakamura, K. Shimizu, Tetrahedron Lett. 52(3), 426-429 (2011). LINK

    2010

    16. “Minimally Invasive Cytoselective Radiation Therapy Using Boron Neutron Capture Reaction” H. Nakamura, YAKUGAKU ZASSHI 130(12) 1687-1694 (2010).

    15. “Salicylate Restores Transport Function and Anion Exchanger Activity of Missense Pendrin Mutations” K. Ishihara, S. Okuyama, S. Kumano, K. Iida, H. Hamana, M. Murakoshi, T. Kobayashi, S. Usami, K. Ikeda, Y. Haga, K. Tsumoto, H. Nakamura, N. Hirasawa, H. Wada, Hearing Res. 270, 110-118 (2010). LINK

    14. ホウ素の中性子捕捉反応を利用した低侵襲細胞選択的放射線療法 中村浩之, Yakugaku Zasshi 130, 1687-1694 (2010). LINK

    13. “Selective Inhibition of EGFR and VEGFR2 Tyrosine Kinases Controlled by a Boronic Acid Substituent on 4-Anilinoquinazolines” H. Nakamura, R. Horikoshi, T. Usui, H. S. Ban, Med. Chem. Commun.1, 282-286 (2010). LINK One of the top ten accessed articles from the online version of MedChemComm in the Royal Cemical Society journals!

    12. “Identification of HSP60 as a Primary Target of ortho-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor” H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura, J. Am. Chem. Soc.132(34), 11870-11871 (2010). LINK

    11. リポソームを用いる中性子捕捉治療 上野学、潘鉉承、中村浩之 Drug Delivery System, 25(5), 474-482 (2010). LINK

    10. “Undecahydro-closo-dodecaborates as Good Leaving Groups in Organic Synthesis: Generation of Substituted Styrenes via Elimination of Arylethyl Dodecaborates” A. R. Genady, H. Nakamura, Org. Biomol. Chem. 8, 4427-4435 (2010). LINK

    9. 中性子捕捉治療のためのナノカプセル型ホウ素薬剤送達システム(BDS)の開発 中村浩之, Pharm. Tech. Japan (invited) 26, 1005-1012 (2010). LINK

    8. “Discovery of Carboranes as Inducers of 20S Proteasome Activity” H. S. Ban, H. Minegishi, K. Shimizu, M. Maruyama, Y. Yasui, H. Nakamura, ChemMedChem. 5(8), 1236-1241 (2010). LINK

    7. “Synthesis of Triazolyl Methyl-substituted Amino- and Oxy-undecahydrododecaborates for Potential Application in Boron Neutron Capture Therapy” M. E. El-Zaria, A. R. Genady, H. Nakamura, New J. Chem. 34, 1612-1622 (2010). LINK

    6. “Copper(I)-Catalyzed Substitution Reactions of Propargylic Amines: Importance of Csp-Csp3 Bond Cleavage in Generation of Iminium Intermediates” T. Sugiishi, A. Kimura, H. Nakamura, J. Am. Chem. Soc. 132 (15), 5332-5333 (2010). LINK

    5. “Suppression of Hypoxia-induced HIF-1α Accumulation by VEGFR Inhibitors: Different Profiles of AAL993 versus SU5416 and KRN633” H. S. Ban, M. Uno, H. Nakamura, Cancer Lett. 296(1), 17-26 (2010). LINK

    4. “closo-Dodecaborate Lipid Liposomes as New Boron Delivery Vehicles for Neutron Capture Therapy of Cancers” M. Ueno, H. S. Ban, K. Nakai, Y. Kaneda, A. Matsumura, H. Nakamura, Bioorg. Med. Chem. 18, 3059-3065 (2010).

    3. “Boron-Containing Phenoxyacetanilide Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors” K. Shimizu, M. Maruyama, Y. Yasui, H. Minegishi, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 20(4), 1453-1456 (2010). LINK

    2. “Enhancement of EGFR Tyrosine Kinase Inhibition by C-C Multiple Bonds-Containing Anilinoquinazolines” H. S. Ban, Y. Tanaka, W. Nabeyama, M. Hatori, H. Nakamura, Bioorg. Med. Chem. 18(2), 870-879 (2010). LINK

    1. “Boron-Containing Protoporphyrin IX Derivatives and Their Modification for Boron Neutron Capture Therapy: Synthesis, Characterization, and Comparative In Vitro Toxicity Evaluation” M. E. El-Zaria, H. S. Ban, H. Nakamura, Chem. Eur. J. 16(5), 1543-1552 (2010). LINK

    2009

    6. “New Strategy for Synthesis of Mercaptoundecahydrododecaborate Derivatives via Click Chemistry: Possible Boron Carriers and Visualization in Cells for Neutron Capture Therapy” M. E. El-Zaria, H. Nakamura, Inorg. Chem. 48(24), 11896-11902 (2009). LINK

    5. “New Types of Potential BNCT Agents, o-Carboranyl Aminoalcohols” C.-H. Lee, G. F. Jin, J. G. Joung, J.-D. Lee, H. S. Ban, H. Nakamura, J.-K. Cho, S. O. Kang, Tetrahedron Lett. 50(24), 2960-2963 (2009). LINK

    4. “Discovery of Boron-Conjugated 4-Anilinoquinazoline as a Prolonged Inhibitor of EGFR Tyrosine Kinase” H. S. Ban, T. Usui, W. Nabeyama, H. Morita, K. Fukuzawa, H. Nakamura, Org. Biomol. Chem. 7 (21), 4415-4427 (2009). LINK

    3. “Synthesis and Biological Evaluation of Boron Peptide Analogues of Belactosin C as Proteasome Inhibitors” H. Nakamura, M. Watanabe, H. S. Ban, A. Asai, Bioorg. Med. Chem. Lett. 19(12), 3220-3224 (2009). LINK

    2. “Discovery of 1-[4-(N-Benzylamino)phenyl]-3-phenylurea Derivatives as a  ew Class of Hypoxia-Inducible Factor-1α Inhibitors” M. Uno, H. S. Ban, H. Nakamura, Bioorg. Med. Chem. Lett. 19(12), 3166-3169 (2009). LINK

    1. “Development of Boron Nano Capsules for Neutron Capture Therapy” H. Nakamura, M. Ueno, H. S. Ban, K. Nakai, K. Tsuruta, Y. Kaneda, A. Matsumura, Appl. Radiat. Isotope. 67. S84-S87 (2009). LINK

    ~2008

    “Synthesis and Characterization of o-Carboranylthiolate Substituted 1,3,5-Triazines” C.-H. Lee, G. F. Jin, H.-S. Kim, H. Nakamura, J.-D. Lee, Bull. Korean Chem. Soc. 29(3), 697-700 (2008). LINK

    “Preparation of Boronated Heterocyclic Compounds Using Intramolecular Cyclization Reaction” C.-H. Lee, G. F. Jin, H.-S. Kim, H. Nakamura, Y. Chung, J.-D. Lee, Bull. Korean Chem. Soc. 29(2), 357-362 (2008). LINK

    “Development of Boron Delivery System for Neutron Capture Therapy of Cancer” H. Nakamura, Progress in Drug Delivery System XVII, 19-24 (2008).

    “Synthesis of Allenes via CuBr-catalyzed Homologation of Alk-1-ynes Accelerated by Microwave” H. Nakamura, T. Sugiishi, Y. Tanaka, Tetrahedron Lett. 49(50), 7230-7233 (2008). LINK

    “Phase-Vanishing Methods Based on Fluorous Phase Screen. A Simple Way for Efficient Execution of Organic Synthesis” I. Ryu, H. Matsubara, H. Nakamura, D. P. Curran, Chem. Rec. 8(6), 351-363 (2008). LINK

    “Molecular Effects of the Tissue-Nonspecific Alkaline Phosphatase Gene Polymorphism (787T>C) Associated with Bone Mineral Density” N. Sogabe, K. Oda, H. Nakamura, H. Orimo, H. Watanabe, T. Hosoi, M. Goseki-Sone, Biomed. Res. 29(4), 213-219 (2008). LINK

    がん中性子捕捉療法と次世代ホウ素デリバリーシステム 中村浩之、臨床血液 (invited), 49(5) 294-301 (2008). LINK

    “Allene as an Alternative Functional Group for Drug Design: Effect of C-C Multiple Bonds Conjugated with Quinazolines on EGFR Tyrosine Kinase Inhibition” H. S. Ban, S. Onagi, M. Uno, W. Nabeyama, H. Nakamura, ChemMedChem. 3, 1094-1103 (2008). LINK

    “Synthesis of closo-Dodecaboryl Lipids and Their Liposomal Formation for Boron Neutron Capture Therapy” H. Nakamura, J.-D. Lee, M. Ueno, Y. Miyajima, H. S. Ban, NanoBiotechnology (invited), 3, 135-145 (2007). LINK

    “Synthesis of 1,2-Dihydroisoquinolines via Palladium (0)-Catalysed Addition-Cycloaddition of Pronucleophiles to ortho-Alkynylaldimines” H. Nakamura, H. Saito, M. Nanjo, Tetrahedron Lett. 49, 2697-2700 (2008). LINK

    “Synthesis of Mono- and 1,3-Disubstituted Allenes from Propargylic Amines via Palladium-Catalysed Hydride-Transfer Reaction” H. Nakamura, M. Ishikura, T. Sugiishi, T. Kamakura, J-F. Biellmann, Org. Biomol. Chem. 6, 1471-1477 (2008). LINK

    “De novo Design and Synthesis of N-Benzylanilines as New Candidates for VEGFR Tyrosine Kinase Inhibitors” M. Uno, H. S. Ban, W. Nabeyama, H. Nakamura, Org. Biomol. Chem. 6, 979-981 (2008). LINK Selected in the RSC’s Chemical Biology Research Articles!

    “Liposomal Boron Delivery System for Neutron Capture Therapy” H. Nakamura, YAKUGAKU ZASSHI (Review)128, 193-208 (2008). LINK

    “Synthesis and Characterization of Polar Functional Group Substituted Mono- and Bis-(o-carboranyl)-1,3,5-triazine Derivatives” C.-H. Lee, G. F. Jin, J. H. Yoon, Y. J. Jung, J.-D. Lee, S. Cho, H. Nakamura, S. O. Kang, Tetrahedron Lett. 49, 159-164 (2008). LINK

    “Discovery of Indenopyrazoles as EGFR and VEGFR-2 Tyrosine Kinase Inhibitors by in silico High-Throughput Screening” T. Usui, H. S. Ban, J. Kawada, T. Hirokawa, H. Nakamura, Bioorg. Med. Chem. Lett.18, 285-288 (2008). LINK

    “Synthesis of Dodecaborate-Conjugated Cholesterols for Efficient Boron Delivery in Neutron Capture Therapy” H. Nakamura, M. Ueno, J.-D. Lee, H. S. Ban, E. Justus, P. Fan, D. Gabel, Tetrahedron Lett. 48, 3151-3154 (2007). LINK

    “Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy” J.-D. Lee, M. Ueno, Y. Miyajima, H. Nakamura, Org. Lett. 9, 323-326 (2007). LINK

    “Synthesis and Liposome Formation of B-10 Enriched B12H11S-Substituted Lipid for Boron Delivery System on BNCT” J-D. Lee, H. Nakamura, Advances in Neutron Capture Therapy, 238-241 (2006).

    “Transferrin-Loaded nido-Carborane Liposomes: Synthesis and Intracellular Targeting to Solid Tumors for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, Y. Kuwata, S. Masunaga, K. Ono, K. Maruyama, Advances in Neutron Capture Therapy, 195-198 (2006).

    “A New NEDO Reseach Project Toward Hospital Based Accelerator BNCT using Advanced DDS system” A. Matsumura, Y. Mori, Y. Kaneda, K. Hashimoto, K. Nakai, T. Yamamoto, H. Nakamura, K. Akamatsu, T. Asano,S. Lee, Y. Sakurai, H. Kumada, K. Yamamoto, Y. Shibata, T. Shibata, T. Nakahara, M. Mutoh, H. Sakae, Y. Yuasa,Y. Satoh, H. Sakurabata, S. Muraki, T. Nagayama, Advances in Neutron Capture Therapy, 74-76 (2006).

    “Selective Inhibition of EGFR and VEGER Tyrosine Kinases Controlled by a Boronic Acid Substituent on 4-Anilinoquinazolines” H. Nakamura, T. Usui, R. Horikoshi, W. Nabeyama, H. S. Ban, YAKUGAKU ZASSHI, 126, 164-165 (2006).

    “Synthesis and Biological Evaluation of Benzamides and Benzamidines As Selective Inhibitors of VEGFR Tyrosine Kinases” H. Nakamura, Y. Sasaki, M. Uno, T. Yoshikawa, T. Asano, H. S. Ban, H. Fukazawa, M. Shibuya, Y. Uehara, Bioorg. Med. Chem. Lett. 16, 5127-5131 (2006). LINK

    “Transferrin-Loaded nido-Carborane Liposome: Synthesis and Intracellular Targeting to Solid Tumors for Boron Neutron Capture Therapy” Y. Miyajima, H. Nakamura, Y. Kuwata, J-D. Lee, S. Masunaga, K. Ono, K. Maruyama, Bioconjugate Chem. 17, 1310-1320 (2006). LINK Highlighted in the NIH Alliance for Nanotechnology in Cancer, Nanotech, 2006, September 5.

    “Synthesis and Biological Evaluation of Boron Containing cis-Stilbenes as Apoptotic Tubulin Polymerization Inhibitors” H. Nakamura, H. Kuroda, H. Saito, R. Suzuki, T. Yamori, K. Maruyama, T. Haga, ChemMedChem 1, 729-740 (2006). LINK

    “1,2-Bis(diphenylphosphino)carborane As a Dual Mode Ligand for both the Sonogashira Coupling and Hydride-Transfer Steps in Palladium-Catalyzed One-Pot Synthesis of Allenes from Aryl Iodides” H.Nakamura, T. Kamakura, S. Onagi, Org. Lett. 8, 2095-2098 (2006). LINK

    “Synthesis and Biological Evaluation of Allenic Quinazolines Using Palladium-Catalyzed Hydride-Transfer Reaction” H. Nakamura, S. Onagi, Tetrahedron Lett. 47, 2539-2542 (2006). LINK

    “Synthesis of Water Soluble THIQ Derivatives as Potential Boron Neutron Capture Therapy Agents: N-Functionalized o-Carboranylmethylbenzopiperidines” C-H. Lee, J. M. Oh, J-D. Lee, H. Nakamura, S. O. Kang, Synlett, 275-278 (2006). LINK

    “Synthesis of Ene-Allenes via Palladium-Catalyzed Hydride-Transfer Reaction of Propargylic Amines under Mild Conditions” H. Nakamura, S. Tashiro, T. Kamakura, Tetrahedron Lett. 28, 8333-8336 (2005). LINK

    ドッキングシミュレーションによるキナーゼ阻害剤の分子設計 中村浩之, ファルマシア, 最前線, 12月号, 749-753 (2005).

    “Transferrin-Conjugated Boron Liposomes as a Potent Boron Delivery System for Neutron Capture Therapy” H. Nakamura, Y. Miyajima, Y. Kuwata, S. Masunaga, K. Ono, K. Maruyama, Progress in Drug Delivery System XIV, 45-53 (2005).

    “Synthesis of Hetrocyclic Allenes via Palladium-Catalyzed Hydride-Transfer Reaction of Propargylic Amines” H. Nakamura, S. Onagi, T. Kamakura, J. Org. Chem. 70, 2359-2360 (2005). LINK

    “Functional Analysis of the Single-nucleotide Polymorphism (787T>C) in Tissue-nonspecific Alkaline Phosphatase Gene Associated with Born Mineral Density” M. Goseki-Sone, N. Sogabe, M. Fukushi-Irie, L. Mizoi, H. Orimo, T. Suzuki, H. Nakamura, H. Orimo, T. Hosoi, J. Born Miner. Res. 20, 773-782 (2005). LINK

    “Synthesis and in vivo biodistribution of BPA-Gd-DTPA Complex as a Potential MRI Contrast Carrier for Neutron Capture Thereapy” K. Takahashi, H. Nakamura, S. Fukumoto, K. Yamamoto, H. Fukuda, A. Matsumura, Y. Yamamoto, Bioorg. Med. Chem. 13, 735-743, (2005). LINK

    “trans-1,2-Dibromocyclohexane. The Phase Vanishing Bromination with FC-72 as a Screen Phase” I. Ryu, H. Matsubara, H. Nakamura, D. P. Curran, In The Handbook of Fluorous Chemistry, J. A. Gladysz, D. P. Curran, I. T. Horvath, Eds. Wiley-VCH, Weinheim, (2004). Ch 11.46, pp 468-470. LINK

    “Synthesis and Vesicle Formation of a nido-Carborane Cluster Lipid for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka, K. Maruyama, Progress in Drug Delivery System XIII, 85-94 (2004). LINK

    “Synthesis of 1,2-dihydroisoquinolines via the reaction of ortho-alkynylarylimines with bis-π-allylpalladium” M. Ohtaka, H. Nakamura, Y. Yamamoto, Tetrahedron Lett. 45, 7339-7341 (2004). LINK

    “Synthesis and Vesicle Formation of a nido-Carborane Cluster Lipid for Boron Neutron Capture Therapy” H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka, K. Maruyama, Chem. Commun. 1910-1911 (2004). LINK Selected as “Hot Paper” and introduced in the RSC’s Chemical Science, 2004, 1, C65.

    “Synthesis of N-Functionalized 3,4-o-Carboranylenepiperidines as Potential Boron Neutron Capture Therapy Agents” C-H. Lee, I. D. Yang, J-D. Lee, H. Nakamura, S-O. Kang, Synlett. 1799-1801 (2004). LINK

    “Benzamides and Benzamidines as Specific Inhibitors of Epidermal Growth Factor Receptor and v-Src Protein Tyrosine Kinases” T. Asano, T. Yoshikawa, T. Usui, H. Yamamoto, Y. Yamamoto, Y. Uehara, H. Nakamura, Bioorg. Med. Chem. 12, 3529-3542 (2004). LINK

    “Synthesis of Allenes via Palladium-Catalyzed Hydrogen Transfer Reactions: Propargylic Amines As an Allenyl Anion Equivalent” H. Nakamura, T. Kamakura, M. Ishikura, J-F. Biellmann, J. Am. Chem. Soc.126, 5958-5959 (2004).

    “Synthesis and Biological Evaluation of Benzamindes and Benzamidines: Structural Requirement of a Pyrimidine Ring for Inhibition of EGFR Tyrosine Kinase” T. Asano, T. Yoshikawa, H. Nakamura, Y. Uehara, Y. Yamamoto, Bioorg. Med. Chem. Lett. 14, 2299-2302 (2004). LINK

    “Design, Synthesis, and Biological Evaluation of Aminoboronic Acids as Growth Factor Receptor Inhibitors for EGFR and Flt-1 Tyrosine Kinases” T. Asano, H. Nakamura, Y. Uehara, Y. Yamamoto, ChemBioChem, 5, 483-490 (2004). LINK

    “o-Carboranyl Derivatives of 1,3,5-s-Triazines: Structures, Properties, and in vitro Activities” H-G. Lim, J-D. Lee, Y-J. Lee, C-H. Lee, J. Ko, H. Nakamura, S-O. Kang, Appl. Organometal. Chem. 17, 539-548 (2003). LINK

    “A Fluorous Solvent as a New Phase-Screen Medium between Reagents and Reactants in the Bromination and Chlorination of Alcohols” H. Nakamura, T. Usui, H. Kuroda, I. Ryu, H. Matsubara, S. Yasuda, D. P. Curran, Org. Lett. 5, 1167-1169 (2003).

    “Phase-Vanishing Reactions that Use Fluorous Media as a Phase Screen. Facile, Controlled Bromination of Alkenes by Dibromine and Dealkylation of Aromatic Ethers by Boron Tribromide” I. Ryu, H. Matsubara, S. Yasuda, H. Nakamura, D. P. Curran, J. Am. Chem. Soc. 124, 12946-12947 (2002) LINK

    “Tandem Nucleophilic Allylation-Alkoxyallylation of Alkynylaldehydes via Amphiphilic Bis-p-allylapalladium Complexes” H. Nakamura, M. Ohtaka, Y. Yamamoto, Tetrahedron Lett. 43, 7631-7633 (2002). LINK

    “A Convenient Synthesis of the Novel carboranyl-substituted Tetrahydroisoquinolines: Application to the Biologically Active Agent for BNCT” J-D. Lee, C-H. Lee, H. Nakamura, J. Ko,S-O.Kang, Tetrahedron Lett. 43, 5483-5486 (2002).

    “Palladium-Catalyzed Aminoallylation of Activated Olefins with Allylic Halides and Certain Amines” K. Aoyagi, H. Nakamura, Y. Yamamoto, J. Org. Chem. 67, 5977-5980 (2002). LINK

    “Nucleophilic Allylation-Heterocyclization via Bis-p-allylpalladium Complexes: Synthesis of Five- and Six-Membered Heterocycles” Bao, H. Nakamura, A. Inoue, Y. Yamamoto, Chem. Lett. 158-159 (2002). LINK

    “o-Carboranyl derivatives of 1,3,5-triazines” H.-G. Lim, J.-D. Lee, Y.-J. Lee, C.-H. Lee, H. Nakamura, S.-H. C.-H. Lee, B. Jun, J. Ko, S.-O. Kang, Research and Development in Neutron Capture Therapy, W. Sauerwein, R. Moss, A. Wittig, Eds. p-37-42, Monduzzi, Bologna (2002).

    “Synthesis of carboranyl derivatives of a tetrahydroisoquinoline” J-D. Lee, C-H. Lee, H. Nakamura, S-H. Lee, C-H. Lee, B. Jun, J. Ko, S-O. Kang, Research and Development in Neutron Capture Therapy, W. Sauerwein, R. Moss, A. Wittig, Eds. p-31-35, Monduzzi, Bologna (2002).

    “Novel Carboranes with a DNA Binding Unit for the Treatment of Cancer by Boron Neutron Capture Therapy” L.F. Tietze, U. Griesbach, U. Bothe, H. Nakamura, Y. Yamamoto, ChemBioChem, 3, 219-225 (2002).

    “Formation of Cyclic Ethers via the Palladium-Catalyzed Cycloaddition of Activated Olefins with Allylic Carbonates Having a Hydroxy Group at the Terminus of the Carbon Chain” M. Sekido, K. Aoyagi, H. Nakamura, C. Kabuto, Y. Yamamoto, J. Org. Chem. 66, 7142-7147 (2001). LINK

    “Fluorous Triphasic Reactions: Transportative Deprotection of Fluorous Silyl Ethers with Concomitant Purification” H. Nakamura, B. Linclau, D. P. Curran, J. Am. Chem. Soc. 123, 10119-10120 (2001). LINK

    “ortho-Carboranyl Glycosides for the Treatment of Cancer by Boron Neutron Capture Therapy” L. F. Tietze, U. Bothe, U. Griesbach, M. Nakaichi, T. Hasegawa, H. Nakamura, Y. Yamamoto, Bioorg. Med. Chem. 9, 1747-1752 (2001). LINK

    “The Fate of Bis-p-allylpalladium Complexes in the Co-existence of Aldehydes (or Imines) and Allylic Chlorides. Stille Coupling versus Allylation of Aldehydes (or Imine)” H . Nakamura, B. Ming, Y. Yamamoto, Angew. Chem. Int. Ed. Engl. 40, 3208-3210 (2001). LINK

    “Carboranyl Bisglycosides for the Treatment of Cancer by Boron Neutron Capture Therapy” L. F. Tietze, U. Bothe, U. Griesbach, M. Nakaichi, T. Hasegawa, H. Nakamura, Y. Yamamoto, ChemBioChem, 2, 326-334 (2001). LINK

    “Facile Allylative Dearomatization Catalyzed by Palladium” B. Ming, H. Nakamura, Y. Yamamoto, J. Am. Chem. Soc. 123, 759-760 (2001). LINK

    “Catalytic Amphiphilic Allylation via Bis-p-allylpalladium Complexes and Its Application to the Synthesis of Medium-Sized Carbocycles” H. Nakamura, K. Aoyagi, J. Shim, Y. Yamamoto, J. Am. Chem. Soc. 123, 372-377 (2001). LINK

    “A Concise Synthesis of Chiral L-(4-Boronophenyl)alanine from L-Tyrosine” H. Nakamura, M. Fujiwara, Y. Yamamoto, Frontiers in Neutron Capture Therapy, Eds M. F. Hawthorn, K. Shelly, R. J. Wiersema, p765-768 Kluwer Academic/Plenum Publishers, New York (2001).

    “In vitro Uptake Study of 5-Carboranyluridine and Its Derivatives” T. Hasegawa, M. Nakaichi, S. Nakama, H. Nakamura, Y. Yamamoto, M. Takagaki, A. Takeuchi, Frontiers in Neutron Capture Therapy, Eds M. F. Hawthorn, K. Shelly, R. J. Wiersema, p1003-1008 Kluwer Academic/Plenum Publishers, New York (2001).

    “In Vivo Evaluation of Carborane Gadolinium-DTPA Complex as an MR Imaging Boron Carrier” H. Nakamura, H. Fukuda, F. Girard, T. Kobayashi, H. Nemoto, J. Cai, K. Yoshida, Y. Yamamoto, Chem. Pharm. Bull. 48, 1034-1038 (2000). LINK

    “A Practical Method for the Synthesis of Enantiomerically Pure 4-Borono-L-phenylalanine” H. Nakamura, M. Fujiwara, Y. Yamamoto, Bull. Chem. Soc. Jpn. 73, 231-235 (2000).

    “Palladium Catalyzed Cyanoallylation of Activated Olefins” H. Nakamura, H. Shibata, Y. Yamamoto. Tetrahedron Lett. 41, 2911-2914 (2000). PDF file

    “Preparation and application of polymer-supported chiral p-allylpalladium catalyst for the allylation of imines” B. Ming, H. Nakamura, Y. Yamamoto, Tetrahedron Lett. 41, 131-134 (2000). LINK

    “Palladium(0) Catalyzed Cope Rearrangement of Acyclic 1,5-Dienes. Bis(p-allyl)palladium(II) Intermediate” H. Nakamura, H. Iwama, M. Ito, Y. Yamamoto, J. Am. Chem. Soc. 121 10850-10851(1999). PDF file

    “Synthesis of a New Amphiphilic ortho-Carborane Derivative as a Potential BNCT Agent: 4-[N,N-Formyl-(ortho-carboranylmethyl)-amino]-benzoyl-L-glutamic Acid” K.-Y. Rho, Y.-J. Cho, C.-M. Yoon, H. Nakamura, Tetrahedron Lett. 40, 4821-4824 (1999). LINK

    “A Concise and Stereospecific One-Shot Synthesis of Bicyclo[3,3,1]nonenols from Dimethyl 1,3-Acetonedicarboxylate and Enals via the Sequential Michael Addition-Intramolecular Aldolization” K. Aoyagi, H. Nakamura, Y. Yamamoto, J. Org. Chem. 64, 4148-4151 (1999). LINK

    “Chiral p-Allylpalladium-Catalyzed Asymmetric Allylation: Replacement Allylstannanes by Allylsilanes” K. Nakamura, H. Nakamura, Y. Yamamoto, J. Org. Chem. 64, 2614-2615 (1999). LINK

    “Novel Addition Reactions of Silyl- and Stannyl-ortho-carboranes to Carbonyl Compounds” H. Nakamura, Y. Yamamoto, Collect. Czech. Chem. Commun. 64, 829-846 (1999). LINK

    “The Synthesis of Carborane Gadolinium-DTPA Complex for Boron Neutron Capture Therapy” H. Nemoto, J. Cai, H. Nakamura, M. Fujiwara, Y. Yamamoto, J. Organomet. Chem. 581, 170-175 (1999). LINK

    “Synthetic Utility of o-Carborane: Novel Protective Group for Aldehydes and Ketones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Organomet. Chem. 574, 107-115 (1999). LINK

    “Relaxation properties of a dual-labeled probe for MRI and neutron capture therapy” A. T. Tatham, H. Nakamura, E. C. Wiener, Y. Yamamoto, Mag. Res. Med. 42, 32-36 (1999). LINK

    “The Renaissance of p-Allylpalladium-catalyzed Organic Synthesis” H. Nakamura, Y. Yamamoto, J. Syn. Org. Chem. Jpn. 56, 395-405(1998).

    “Palladium Catalyzed Regioselective b-Acetonation-a-Allylation of Activated Olefins in One Shot” J.-G. Shim, H. Nakamura, Y. Yamamoto, J. Org. Chem. 63, 8470-8474 (1998). LINK

    “A Concise Synthesis of Enantiomerically Pure L-(4-Boronophenyl)alanine from L-Tyrosine” H. Nakamura, M. Fujiwara, Y. Yamamoto, J. Org. Chem. 63, 7529-7530 (1998). LINK

    “Palladium-Catalyzed Alkoxyallylation of Activated Olefins” H. Nakamura, M. Sekido, M. Ito, Y. Yamamoto, J. Am. Chem. Soc. 120, 6838-6839 (1998). LINK

    “Catalytic Asymmetric Allylation of Imines via Chiral Bis-p-allylpalladium Complexes” H. Nakamura, K. Nakamura, Y. Yamamoto, J. Am. Chem. Soc. 120, 4242-4243 (1998). LINK

    “Tetrabutylammonium Fluoride Promoted Novel Reactions of o-Carborane: Inter- and Intramolecular Additions to Aldehydes and Ketones and Annulation via Enals and Enones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Am. Chem. Soc. 120, 1167-1171 (1998). LINK

    “Amphiphilic Catalytic Allylating Reagent, Bis-p-allylpalladium Complex” H. Nakamura, J-G. Shim, Y. Yamamoto, J. Am. Chem. Soc. 119, 8113-8114 (1997). LINK

    “Synthesis of Carboranes Containing Azulene Framework and In vitro Evaluation as Boron Carriers” H. Nakamura, M. Sekido, Y. Yamamoto, J. Med. Chem. 40, 2825-2830 (1997). LINK

    “o-Carborane as a Novel Protecting Group of Aldehydes and Ketones” H. Nakamura, K. Aoyagi, Y. Yamamoto, J. Org. Chem. 62, 780-781 (1997). LINK

    “A Novel [3+2] Annulation between o-Carboranyltrimethylsilane and Conjugated Carbonyl Compounds” H. Nakamura, K. Aoyagi, B. Singaram, J. Cai, H. Nemoto, Y. Yamamoto, Angew. Chem. Int. Ed. Engl. 36, 367-369 (1997). LINK

    “Tetrabutylammonium Fluoride Promoted Regiospecific Reaction of Trimethylsilyl-o-carborane with Carbonyl Compounds” J. Cai, H. Nemoto, H. Nakamura, B. Singaram, Y. Yamamoto, Advances in Boron Chemistry, Ed. W. Siebert, p112-115, The Royal Society of Chemistry (1997).

    “Rat Tumor Imaging with B-10 Carborane Gadolinium Complex” F. Girard, H. Nakamura, H. Fukuda, Y. Yamamoto, K, Yoshida, Recent Advances in Biomedical Imaging, Ed. Y. Ishii et al., p201-207, Elsevier Science (1997).

    “Synthesis of Carborane Containing Azlene Framework Using New Palladium Catalyzed Reaction” H. Nakamura, M. Sekido, Y. Yamamoto, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p42-45, Plenum Press, New York (1997).

    “MR Imaging of Rat Tumor with 10B Carborane Gadolinium Complex” F. Girard, H. Fukuda, H. Nakamura, Y. Yamamoto, K. Yoshida, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p271-275, Plenum Press, New York (1997).

    “A New Synthetic Method of All Carboxylate-free DTPA Derivatives and Its Application to the Synthesis of Gd-Carborane Complex” Y. Yamamoto, J. Cai, H. Nemoto, H. Nakamura, F. Girard, K. Yoshida, H. Fukuda, Advances in Neutron Capture Therapy, Eds. B. Larsson, J. Crawford, R. Weinreich, p436-439, Plenum Press, New York (1997).

    “Tetrabutylammonium Fluoride Promoted Regiospecific Reactions of Trimethylsilyl-o-Carborane with Aldehydes” J. Cai, H. Nemoto, H. Nakamura, B. Singaram, Y. Yamamoto, Chem. Lett. 9, 791-792 (1996).

    “Palladium and Platinum Catalyzed Addition of Aldehydes and Imines with Allylstannanes. Chemoselective Allylation of Imines in the Presence of Aldehydes” H. Nakamura, H. Iwama, Y. Yamamoto, J. Am. Chem. Soc. 118, 6641-6647 (1996). LINK

    “Unprecedented Highly Chemoselective Allylation of Imines in the Presence of Aldehydes via Palladium Catalyzed Allylstannane Reaction” H. Nakamura, H. Iwama, Y. Yamamoto, Chem. Commun. 1459-1460 (1996). LINK

    “Netropsin and Distamycin Analogues Bearing ortho-Carborane” Y. Yamamoto, J. Cai, H. Nakamura, N. Sadayori, H. Nemoto, Cancer Neutron Capture Therapy, Ed. Y. Mishima, 177-182, Plenum Press, New York (1996).

    “Palladium and Platinum-catalyzed Addition of Aldehydes with Allylstannanes” H. Nakamura, N. Asao, Y. Yamamoto, J. Chem. Soc. Chem. Commun. 1273-1274 (1995). LINK

    “Synthesis of Netropsin and Distamycin Analogues Bearing o-Carborane and Their DNA Recognition” Y. Yamamoto, J. Cai, H. Nakamura, N. Sadayori, N. Asao, H, Nemoto, J. Org. Chem. 60, 3352-3357 (1995).

    “Palladium Catalyzed Addition of 1-Carboranyltributyltin to Aldehydes” H. Nakamura, N. Sadayori, M. Sekido, Y. Yamamoto, J. Chem. Soc. Chem. Commun. 22581-2582 (1994).

    “Synthesis of New 10B Carriers and Their Selective Uptake by Cancer Cells” Y. Yamamoto, H. Nemoto, H. Nakamura, S. Iwamoto, Current Topics in the Chemistry of Boron Ed. G. Kabalka, p149-154, The Royal Society of Chemistry (1994).

    “Synthesis and Biological Properties of Carboranylaziridine” Y. Yamamoto, H. Nakamura, H. Nemoto, Advances in Neutron Capture Therapy, Eds. A.H. Soloway, R.F. Barth, D.E. Carpenter, 305-308, Plenum Press, New York (1993).

    “1-Carboranyl-3-methylaziridino-2-propanol. Synthesis, Selective Uptake by B-16 Melanoma, and Selective Cytotoxicity toward Cancer Cells” Y. Yamamoto, H. Nakamura, J. Med. Chem. 36, 2232-2234 (1993).LINK

    “Regio- and Stereo-selective Ring Opening of Epoxides with Amide Cuprate Reagents” Y. Yamamoto, N. Asao, M. Meguro, N. Tsukada, H. Nemoto, S. Sadayori, J. Gerald Wilson, H. Nakamura, J. Chem. Soc. Chem. Commun. 1201-1203 (1993). LINK

    “Boron-11 NMR of Boron Compounds in the Presence of Cancer Cells” Y. Yamamoto, S. Takamatsu, H. Nakamura, J. Magn. Res. Series B, 101, 198-200 (1993).

    “A New Water-soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy” H. Nemoto, S. Iwamoto, H. Nakamura, Y. Yamamoto, Chem. Lett. 465-468 (1993).

    “Synthesis of Carboranes Containing Nucleoside Bases” Y. Yamamoto, T. Seko, H. Nakamura, H. Nemoto, Heteroatom Chem. 3, 239-244 (1992). LINK

    “Polyols of a Cascade Type as a Water-Solubilizing Element of Carborane Derivatives for Boron Neutron Capture Therapy” H. Nemoto, J. G. Wilson, H. Nakamura, Y. Yamamoto, J. Org. Chem. 57, 435 (1992). LINK

    “Synthesis of Carboranes Containing Nucleoside Bases. Unexpectedly High Cytostatic and Cytocidal Toxicity toward Cancer Cells” Y. Yamamoto, T. Seko, H. Nakamura, H. Nemoto, H. Hojo, N. Mukai, Y. Hashimoto, J. Chem. Soc. Chem. Commun. 157-158 (1992).LINK

     

     

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