TOKYO INSTITUTE OF TECHNOLOGY, Chemical Resources Laboratory, Synthetic Organic Division, Nakamura & Okada Laboratory

Papers (2011〜2020)



        1. N. Sugisawa, H. Nakamura, S. Fuse
          “Recent advances in the continuous-flow reactions using metal-free homogeneous catalysts”,Catalysts10(11), 1321 (2020). DOI:10.3390/catal10111321.
        2. 北村 宙士、小竹 佑磨、川村 淳、布施 新一郎、中村 浩之
          「入手容易なマイクロミキサーを用いたリポソーム調製法の開発」、製剤機械技術学会誌 29(4), 407-413 (2020).
        3. A. Anufriev, I. B. Sivaev, H. Nakamura
          “Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept”, Phosphorus, Sulfur and Silicon, 195(11), 910-917 (2020). DOI:10.1080/10426507.2020.1804151
        4. S. Yugandar, T. Morita, H. Nakamura
          “Rhodium(III)-Catalyzed Direct C-H Functionalization of Isoxazoles with Alkynes, Alkenes and Sulfoxonium Ylides”, Org. Biomol. Chem. 18, 8625. (2020). DOI:10.1039/D0OB02027C.
        5. K. Kawai, K. Nishimura, S. Okada, S. Sato, M. Suzuki, T. Takata, H. Nakamura
          “Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy”, Mol. Pharmaceutics, 17(10), 3740 (2020). DOI:10.1021/acs.molpharmaceut.0c00478.
        6. T. Masuzawa, S. Sato, T. Niwa, H. Taguchi, H. Nakamura, T. Oyoshi
          “G-Quadruplex-Proximity Protein Labeling Based on Peroxidase Activity”, Chem. Commun., 56, 11641 (2020). DOI:10.1039/D0CC02571B.
        7. Y. Asawa, A. Yoshimori, J. Bajorath, H. Nakamura
          “Prediction of an MMP-1 Inhibitor Activity Cliff Using the SAR Matrix Approach and Its Experimental Validation”Sci. Rep., 10, 14710 (2020). DOI:10.1038/s41598-020-71696-2.
        8. S. Tanuma, T. Oyama, A. Yoshimori, K. Katsuragi, Y. Shibasaki, Y. Asawa, H. Yamazaki, K. Makino, M. Okazawa, Y. Ogino, Y. Sakamoto, M. Nomura, A. Sato, H. Abe, H. Nakamura, H. Takahashi, N. Tanuma, F. Uchiumi
          “Structural insights into the tunnel-shaped cavity of human nicotinamide phosphoribosyltransferase using a close structural set of azacyclohexane-motif inhibitors”,Molecules25(16), 3633 (2020). DOI:10.3390/molecules25163633.
        9. T. Nakagawa, H. Kawashima, T. Morita, H. Nakamura
          “Water-soluble closo-Docecaborate-conjugated Pteroyl Derivatives for Boron Neutron Capture Therapy: Evidence of Targeting to Folate Receptor-Mediated Cell Uptake”,Cells, 9(7), 1615 (2020).DOI:10.3390/cells9071615.
        10. J. Kawamura, H. Kitamura, Y. Otake, S. Fuse, H. Nakamura
          “Size-Controllable and Scalable Production of Liposomes Using a V-Shape Mixer Micro-Flow Reactor”, Org. Process Res. Dev., 24(10), 2122 (2020). DOI:10.1021/acs.oprd.0c00174.
        11. S. Sato, H. Nakamura
          “Labeling of Peroxidase-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click”, Chem. Pharm. Bull., 68(9), 885-890 (2020). DOI:10.1248/cpb.c20-00434.
        12. M. Tsushima, S. Sato, K. Nakane, H. Nakamura
          “Target protein identification on the photocatalyst-functionalized magnetic affinity beads”, Current Protocols (invited), 101, 1 (2020). DOI:10.1002/cpps.108.
        13. G. Li, C. Wang, Y. Li, K. Shao, Wang, X. Guo, W. Zhao, H. Nakamura
          “Zinc (II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylamines with sp and sp3 Carbon Pronucleophiles: Facile Access to Multifunctionalized Tetrahydroquinolines”, Chem. Commun., 56, 7333-7336 (2020). DOI:10.1039/D0CC02921A.
        14. S. Fuse, W. Moriya, S. Sato, H. Nakamura
          “Investigation of detailed influence of acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity”, Bioorg. Med. Chem., 28, 115558 (2020). DOI:10.1016/j.bmc.2020.115558.
        15. S. Sato, K. Nakane, H. Nakamura
          “A Laccase-Catalysed Tyrosine Click Reaction”, Org. Biomol. Chem., 18, 3664 (2020). DOI:10.1039/d0ob00650e.
        16. T. Morita, S. Fuse, H. Nakamura
          “Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines”, Org. Lett., 22(9), 3460-3463 (2020). DOI:10.1021/acs.orglett.0c00910.
        17. Y. Otake, Y. Shibata, Y. Hayashi, S. Kawauchi, H. Nakamura, and S. Fuse
          N-Methylated peptide synthesis via acyl N-methylimidazolium cation generation accelerated by a Brønsted acid”, Angew. Chem. Int. Ed., 59(31), 12925-12930 (2020). DOI:10.1002/anie.202002106
        18. S. Sato, M. Matsumura, T. Kadonosono, S. Abe, T. Ueno, H. Ueda, H. Nakamura
          “Site-Selective Protein Chemical Modification in Exposed Tyrosine Residues Using Tyrosine Click Reaction”Bioconjugate Chem.31(5), 1417-1424 (2020). DOI:10.1021/acs.bioconjchem.0c00120
        19. W. Yimchuen, T. Kadonosono, Y. Ota, S. Sato, M. Kitazawa, T. Shiozawa, T. Kuchimaru, M. Taki, Y. Ito, H. Nakamura, S. Kizaka-Kondoh
          “Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold”, RSC Advance, 10(26), 15154-15162 (2020). DOI:10.1039/D0RA00427H
        20. N. Sugisawa, H. Nakamura, S. Fuse
          “Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach”, Chem. Commun., 56, 4527 (2020). DOI:10.1039/d0cc01403f  Selected as a Back Cover Picture
        21. 中村浩之
          「ホウ素中性子捕捉療法:がん細胞内でα線を発生させる次世代放射線治療」 DDS学会誌, 35(2), 129-136 (2020). DOI:10.2745/dds.35.129
        22. M. Kaur, P. Singh, R. Meena, F. Nakagawa, M. Suzuki, H. Nakamura, A. Kumar
          “Boron Neutron Capture Therapy Study of 10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line”, Journal of Cluster Science, (2020). DOI:10.1007/s10876-020-01773-z.
        23. H.-J. Kim, H.-S. Cho, H. S. Ban, H. Nakamura
          “Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer”, Biochem. Biophys. Res. Commun., 523(3), 726-732 (2020). DOI:10.1016/j.bbrc.2020.01.031.
        24. S. Kikuchi, S. Sato, H. Nakamura
          “Carrier Proteins-Based Boron Delivery to Tumor”, Appl. Radiat. Isotope, 157, 109011-109014 (2020). DOI:10.1016/j.apradiso.2019.109011.
        25. 中村浩之
          「中性子捕捉療法のためホウ素薬剤研究開発の進展-ホウ素薬剤が今後適応疾患拡大の鍵を握る!」 日本原子力学会誌 62(1), 18-22(2020). DOI:10.3327/jaesjb.62.1_18.
        26. S. Fuse, T. Oishi, K. Matsumura, Y. Hayashi, S. Kawauchi, H. Nakamura
          “The design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents”, Org. Biomol. Chem., 18, 93-101 (2020). DOI:10.1039/C9OB02066G.
        27. N. Sugisawa, Y. Otake, H. Nakamura, and S. Fuse
          “Single-step, rapid, and mild synthesis of β-amino acid N-carboxy anhydrides using micro-flow technology”, Chem. Asian J., 15, 79-84 (2020). DOI:10.1002/asia.201901429Selected as an Inside Cover Picture
        28. S. Fuse, K. Suzuki, T. Kuchimaru, T. Kadonosono, H. Ueda, S. Sato, S. Kizaka-Kondo, and H. Nakamura
          “Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity”, Bioorg. Med. Chem.28(1), 115207 (2020). DOI:10.1016/j.bmc.2019.115207.
        29. M. Kumar, P. Singh, K. Singh, U. S. Gaharwar, R. Meena, M. Kumar, F. Nakagawa, S. Wu, M. Suzuki, H. Nakamura, A. Kumar
          “Boron Nitride (10BN) a prospective material for treatment of cancer by Boron Neutron Capture Therapy (BNCT)”, Materials Letters, 259, 126832-126855 (2020). DOI:10.1016/j.matlet.2019.126832.
        30. J.-H. Choy, H. Nakamura, S. Eom, G. Choi
          “2-Dimensional Nanomaterials with Imaging and Diagnostic Functions for Nanomedicine; A Review”, Bull. Chem. Soc. Jpn., 93, 1-12 (2020). DOI:10.1246/bcsj.20190270.


        1. S. Fuse, K. Masuda, Y. Otake, H. Nakamura
          “Peptide chain elongation using unprotected amino acids in a micro-flow reactor”, Chem. Eur. J., 25(66), 15091-15097 (2019). DOI:10.1002/chem.201903531. Highlighted in Synfacts issue 1/2020, Selected as an Inside Cover Picture
        2. S. Sato, H. Nakamura
          “Protein chemical labeling Using biomimetic radical chemistry”, Molecules, 24(21), 3980 (2019). DOI:10.3390/molecules24213980
        3. M. Tsushima, S. Sato, T. Niwa, H. Taguchi, H. Nakamura
          “Catalyst-Proximity Protein Chemical Labelling on Affinity Beads Targeting Endogenous Lectins.”, Chem. Commun., 55, 13275-13278 (2019). DOI:10.1039/C9CC05231C.
        4. T. Asai, H. Liu, Y. Ozek, S. Sato, T. Hayashi, H. Nakamura
          “Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy”, Appl. Phys. Express, 12(11), 112004 (2019). DOI:10.7567/1882-0786/ab4a5d.
        5. S. Yugandar, H. Nakamura
          “Rhodium(III)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes”, Chem. Commun., 55, 8382-8385 (2019). DOI:10.1039/C9CC03283E. Selected as an Inside Cover Picture
        6. M. Mochizuki, S. Sato, S. Asatyas, Z. J. Leśnikowski, T. Hayashi, H. Nakamura
          “Raman cell imaging with boron cluster molecules conjugated with biomolecules.”, RSC Advances9, 23973-23978 (2019). DOI:10.1039/c9ra04228h.
        7. 佐藤伸一、對馬理彦、中村浩之
          「タンパク質ケミカルラベリングにおける一電子移動反応の活用」 有機合成化学協会誌(特集号2019年5月号「ラジカル種の利用最前線―合成・物性・理論」), 77(5), 463-471 (2019). DOI:10.5059/yukigoseikyokaishi.77.463.
        8. 中村浩之
          「加速器中性子源を用いた中性子捕捉療法の現状と今後の展望」 BIO Clinica, 34(4), 431-434 (2019). LINK
        9. Y. Asawa, K. Katsuragi, A. Sato, A. Yoshimori, S. Tanuma, H. Nakamura
          “Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors”, Bioorg. Med. Chem., 27(13), 2832-2844 (2019). DOI:10.1016/j.bmc.2019.05.013.
        10. S. Ishii, S. Sato, H. Asami, T. Hasegawa, J. Kohno, H. Nakamura
          “Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): Identification of unique modification sites on albumin and investigation of intracellular uptake”, Org. Biomol. Chem., 17, 5496–5499 (2019). DOI:10.1039/C9OB00584F.
        11. S. Sato, M. Yoshida, K. Hatano, M. Matsumura, H. Nakamura
          N’-Acyl-N-methylphenylenediamine as a novel proximity labeling agent for signal amplification in immunohistochemistry”, Bioorg. Med. Chem., 27(6), 1110–1118 (2019). DOI:10.1016/j.bmc.2019.01.036.
        12. S. Fuse, M. Takizawa, S. Sato, S. Okazaki, H. Nakamura
          Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy“, Bioorg. Med. Chem., 27(2), 315–321 (2019). DOI:10.1016/j.bmc.2018.12.006.
        13. T. Kanemitsu, S. Kawabata, M. Fukumura, G. Futamura, R. Hiramatsu, N. Nonoguchi, F. Nakagawa, T. Takata, H. Tanaka, M. Suzuki, S. I. Masunaga, K. Ono, S. I. Miyatake, H. Nakamura, T. Kuroiwa
          “Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats”, Radiat. Environ. Biophys., 58(1), 59–67 (2019). DOI:10.1007/s00411-018-0765-2.


        1. S. Fukuhara, S. Yugandar, S. Fuse, H. Nakamura
          “Synthesis of 3-hydroxy-4-substituted-picolinonitriles from 4-propargylaminoisoxazoles via stepwise and one-pot isoxazolopyridine formation/N-O bond cleavage sequence”, ACS Omega, 3(12), 16472–16476 (2018). DOI:10.1021/acsomega.8b03114.
        2. S. Fuse, Y. Otake, H. Nakamura
          “Peptide synthesis utilizing micro-flow technology”, Chem. Asian J., 13(24), 3818–3832 (2018). DOI:10.1002/asia.201801488.
        3. I. Fuentes, T. García-Mendiola, S. Sato, M. Pita, H. Nakamura, E. Lorenzo, F. Teixidor, F. Marques, C. Viñas
          “Metallacarboranes on the road to anticancer therapies: cellular uptake, DNA interaction and biological evaluation of cobaltabisdicarbollide ([COSAN])”, Chem. Eur. J., 24(65), 17239-17254 (2018). DOI:10.1002/chem.201803178. Selected as a Front Cover Picture
        4. G. F. Jin, H. S. Ban, H. Nakamura, J.-D. Lee
          “o-Carboranylalkoxy-1,3,5-triazine derivatives: Synthesis, characterization, X-ray structural studies, and biological activity”, Molecules, 23(9), 2194-2207 (2018). DOI:10.3390/molecules23092194.
        5. S. Sato, M. Tsushima, H. Nakamura
          “Target-protein-selective inactivation and labelling using oxidative catalyst”, Org. Biomol. Chem., 16, 6168–6179 (2018). DOI:10.1039/C8OB01484A.
        6. Y. Otake, H. Nakamura, S. Fuse
          “Rapid and mild synthesis of amino acid N-carboxy anhydrides using basic-to-acidic flash switching in a micro-flow reactor”, Angew. Chem. Int. Ed., 57(35), 11389-11393 (2018). DOI:10.1002/anie.201803549. 
        7. 中村浩之
          「中性子捕捉療法(BNCT)におけるホウ素薬剤開発」ファルマシア、54(8), 793-797 (2018). DOI:10.14894/faruawpsj.54.8_793.
        8. S. Fuse, K. Matsumura, M. Takizawa, S. Sato, H. Nakamura
          “The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy”, Bioorg. Med. Chem. Lett., 28(18), 3099-3104 (2018). DOI:10.1016/j.bmcl.2018.07.025.

        9. 中村浩之
          「医薬品におけるホウ素化合物の化学 特集「新・元素物語 ホウ素」」月刊化学、73(8), 37-40 (2018). LINK
        10. S. Sato, K. Hatano, M. Tsushima, H. Nakamura
          “1-Methyl-4-aryl-urazole (MAUra) Labels Tyrosine in Proximity to Ruthenium Photocatalyst”, Chem. Commun.54, 5871-5874 (2018). DOI:10.1016/j.bmcl.2018.07.025.
        11. H. Ueda, A. Yoshimori, H. Nakamura
          “Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors”, Bioorg. Med. Chem., 26(12), 3345-3351(2018). DOI:10.1016/j.bmc.2018.05.002

        12. Y. Otake, H. Nakamura, S. Fuse
          “Recent advances in the integrated micro-flow synthesis containing photochemical reactions”, Tetrahedron Lett., 59(18), 1691-1697 (2018). DOI:10.1016/j.tetlet.2018.03.019Selected as a Front Cover Picture
        13. S. Ishii, H. Nakamura
          “Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy”, J. Organomet. Chem., 865, 178-182 (2018). DOI:10.1016/j.jorganchem.2018.02.026.
        14. T. Morita, S. Yugandar, S. Fuse, H. Nakamura
          “Recent progresses in the synthesis of functionalized isoxazoles”,
          Tetrahedron Lett., 59(13), 1159-1171 (2018). DOI:10.1016/j.jorganchem.2018.02.026.
        15. H. Nakamura, S. Kikuchi, K. Kawai, S. Ishii, S. Sato
          “closo-Dodecaborate-conjugated human serum albumins: preparation and in vivo selective boron delivery to tumor”, Pure Appl. Chem., 90(4), 745-753 (2018). DOI:10.1515/pac-2017-1104.
        16. Zeng, Y. Mizuno, K. Nakamura, S. Fuse, H. Nakamura
          ”Compact test set for sensitivity evaluation of photoacoustic contrast agent”, Acoust. Sci. Technol., 39(3), 259-262 (2018). DOI:10.1250/ast.39.259

        17. 中村浩之
          「血清アルブミンを利用したホウ素デリバリーシステム」BIO Clinica, 33(2), 2-5 (2018). LINK
        18. S. Fuse, M. Inaba, S. Sato, M. Joshi, H. Nakamura
          “Synthesis of pyrazolofuropyrazine via one-pot SNAr reaction/intramolecular C-H direct arylation”, Synthesis, 50(7), 1493-1498 (2018). DOI:10.1055/s-0036-1591885.
        19. T. Morita, S. Fukuhara, S. Fuse, H. Nakamura
          “Gold(I)-catalyzed intramolecular SEAr reaction: Efficient synthesis of isoxazole-containing fused heterocycles”, Org. Lett., 20(2), 433–436 (2018). DOI:10.1021/acs.orglett.7b03760. Highlighted in Synfacts issue 4/2018
        20. S. Sato, M. Tsushima, K. Nakamura, H. Nakamura
          “Development and application of catalytic tyrosine modification”, Yakugaku Zasshi, 138(1), 39-46 (2018). DOI:10.1248/yakushi.17-00186-1.
        21. 中村浩之
          「血清アルブミンを利用したホウ素デリバリーシステム」月刊 細胞 50(1), 37-40 (2018). LINK
        22. H. Masui, M. M. Maitani, S. Fuse, A. Yamamura, Y. Ogomi, S. Hayase, T. Kaiho, H. Tanaka, Y. Wada, and T. Takahashi
          “D–π–A dyes containing novel hydantoin anchoring groups for dye-sensitized solar cells”, Asian J. Org. Chem., 7(2), 458-464 (2018). DOI:10.1002/ajoc.201700542.


        1. 布施新一郎、田中浩士、高橋孝志、土井隆行「マンノペプチマイシンアグリコンの合成と立体配置訂正」、有機合成化学協会誌、75(12), 1274-1285 (2017). DOI:10.5059/yukigoseikyokaishi.75.1274
        2. 中村浩之「「展望」中性子捕捉療法のための新しいホウ素薬剤の開発 ─血清アルブミンホウ素キャリア─」Isotope News 753(10), 2-7 (2017). LINK
        3. M. Inai, N. Honda, H. Hazama, S. Akter, S. Fuse, H. Nakamura, T. Nishikawa, Y. Kaneda, K. Awazu “Photodynamic therapy using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane“, Photodiag. Photodyn. Ther., 20, 238-245 (2017). DOI:10.1016/j.pdpdt.2017.10.017.
        4. S. Fuse, M. Takizawa, K. Matsumura, S. Sato, S. Okazaki, H. Nakamura “Thiophene-based, Organic D-π-A dyes as Potent Sensitizers for Photodynamic Therapy”, Eur. J. Org. Chem., 34, 5170–5177 (2017). DOI:10.1002/ejoc.201701019.
        5. 布施新一郎「チオフェン含有有機Donor-π-Acceptor色素の系統的合成と構造-機能相関解明」、有機合成化学協会誌、75(9), 941-954 (2017). DOI:10.5059/yukigoseikyokaishi.75.941.
        6. S. Sato, S. Ishii, H. Nakamura “Development of Albumin-closo-Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3-Photocatalyzed Modification of Tyrosine”, Eur. J. Inorg., 38(39), 4406-4410 (2017). DOI:10.1002/ejic.201700578. Selected as a Front Cover Picture
        7. 中村浩之「血清アルブミンを利用したホウ素デリバリーシステム」、BIO Clinica, 32(7), 669-703 (2017). LINK
        8. M. Inai, N. Honda, H. Hazama, H. Nakamura, H. Yasuda, T. Nishikawa, Y. Kaneda, K. Awazu “Subcellular localization of novel photosensitizer named porphyrus envelope in human prostate cancer cell line PC-3”, JJSLSM, 37(4), 415-420 (2017). DOI: 10.2530/jslsm.jslsm-37_0028
        9. S. Fuse, Y. Otake, H. Nakamura “Integrated Micro-flow Synthesis Based on Photochemical Wolff Rearrangement” (micro review)  Eur. J. Org. Chem., 44, 6466, (2017). DOI:10.1002/ejoc.201700789.
        10. M. Tsushima, S. Sato, H. Nakamura “Selective Purification and Chemical Labeling of Target Protein on Ruthenium Photocatalyst-Immobilized Affinity Beads” Chem. Commun., 53, 4838-4841 (2017). DOI:10.1039/C7CC01595J.
        11. W. Nabeyama, K. Ishihara, H. S. Ban, H. Wada, H. Nakamura “Discovery of (2-Aminophenyl)methanol as a New Molecular Chaperone That Rescues the Localization of P123S Mutant Pendrin Stably Expressed in HEK293 Cells”, Bioorg. Med. Chem., 25(9), 2601–2608 (2017). DOI:10.1016/j.bmc.2017.03.024.
        12. S. Fuse, T. Morita, H. Nakamura “Step-by-Step Multifunctionalization of Isoxazoles based on SEAr Reactions and C-H Direct Arylations.” (short review), Synthesis, 49(11), 2351-2360 (2017). DOI:10.1055/s-0036-1588784.
        13. H. Masui, S. Yosugi, S. Fuse, T. Takahashi “Solution-phase automated synthesis of α-amino aldehyde as a versatile intermediate”, Beilstein J. Org. Chem., 13, 106-110 (2017). DOI:10.3762/bjoc.13.13.
        14. S. Sato, K. Nakamura, H. Nakamura “Horseradish-Peroxidase-Catalyzed Tyrosine Click Reaction”, ChemBioChem.18(5), 475–478 (2017). DOI:10.1002/cbic.201600649.


        1. G. Dormán, H. Nakamura, A. Pulsipher, G. D. Prestwich “The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore”, Chem. Rev., 116(24), 15284–15398 (2016). DOI:10.1021/acs.chemrev.6b00342.
        2. M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu “Effective Photodynamic Therapy in Drug-resistant Prostate Cancer Cells Utilizing a Non-viral Antitumor Vector (a secondary publication)”, Laser therapy, 25(1), 55-62 (2016). DOI:10.5978/islsm.16-OR-05.
        3. Y. Mifune, H. Nakamura, S. Fuse “A Rapid and Clean Synthetic Approach to Cyclic Peptides via Micro-flow Peptide Chain Elongation and Photochemical Cyclization: Synthesis of a Cyclic RGD Peptide”, Org. Biomol. Chem., 14(47), 11244-11249 (2016). DOI:10.1039/C6OB02391F.
        4. S. Fuse, T. Ohuchi, Y. Asawa, S. Sato, H. Nakamura “Development of 1-Aryl-3-furanyl/Thienyl-imidazopyridine Templates for Inhibitors against Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity”, Bioorg. Med. Chem. Lett., 26(24), 5887–5890 (2016). DOI:10.1016/j.bmcl.2016.11.009.
        5. S. Fuse, Y. Mifune, H. Nakamura, H. Tanaka “Total Synthesis of Feglymycin based on a Linear/Convergent Hybrid Approach using Micro-flow Amide Bond Formation”, Nat. Commun., 7, 13491 (2016). DOI:10.1038/ncomms13491.
        6. S. Fuse, K. Matsumura, K. Johmoto, H. Uekusa, H. Tanaka, T. Hirose, T. Sunazuka, S. Ōmura, T. Takahashi “The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-pyridyl-xanthones for Use as Insecticides Starting from Pyripyropene A”, Chem. Eur. J., 22(51), 18450-18455 (2016). DOI:10.1002/chem.201603980. Selected as a Hot Paper
        7. T. Morita, S. Fuse, H. Nakamura “Generation of 4-Isoxazolyl Anion Species: Facile Access to 4-Substituted Isoxazoles”, Angew. Chem. Int. Ed., 55(43), 13580-13584 (2016). DOI:10.1002/anie.201608039. Highlighted in Synfacts issue 12/2016
        8. S. Kikuchi, D. Kanoh, S. Sato, Y. Sakurai, M. Suzuki, H. Nakamura “Maleimide-Functionalized closo-Dodecaborate Albumin Conjugates (MID-AC): The Unique Ligation at both Cysteine and Lysine Residues Enabling to Efficient Boron Delivery to Tumor for Neutron Capture Therapy”, J. Control. Release, 237160–167 (2016). DOI:10.1016/j.jconrel.2016.07.017.
        9. N. Shiraishi, M. Kumazoe, S. Fuse, H. Tachibana, H. Tanaka “The Synthesis of trans-Flavan-3-ol Gallates by Regioselective Oxidative Etherification and Their Biological Evaluation” Chem. Eur. J.22(37), 13050-13053 (2016). DOI:10.1002/chem.201602817.
        10. G. Li, H. Nakamura “Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles”, Angew. Chem. Int. Ed., 55(23), 6758-6761 (2016). DOI:10.1002/anie.201602416. 
        11. H. Hamagami, M. Kumazoe, Y. Yamaguchi, S. Fuse, H. Tachibana, H. Tanaka “6-Azido-6-deoxy-L-idose as a Hetero-bifunctional Spacer for the Synthesis of Azido-containing Chemical Probes”, Chem. Eur. J., 22(36), 12884-12890 (2016). DOI:10.1002/chem.201602044.
        12. R. Suzuki, S. Fuse, H. Tanaka “Synthesis of Asymmetrically Terminal Bifunctionlized Alkanes by Sequential Suzuki-Miyaura Coupling using B-Thexyl Boracyclanes”, Eur. J. Org. Chem., 21, 3478–3481 (2016). DOI:10.1002/ejoc.201600392.
        13. S. Ban, Y. Uto, M. Won, H. Nakamura “Hypoxia-Inducible Factor Inhibitors: A Patent Review (2011-2015)”, Exp. Opin. Ther. Pat., 26(3), 309–322 (2016). DOI:10.1517/13543776.2016.1146252.
        14. M. Sasai, H. Nakamura, N. Sougawa, Y. Sakurai, M. Suzuki, A. Matsuyama, C. M. Lee “Novel Hyaluronan Formulation Enhances the Efficacy of Boron Neutron Capture Therapy for Murine Mesothelioma”, Anticancer Res., 36(3), 907-911 (2016).  LINK
        15. T. Aoyagi, S. Ohira, S. Fuse J. Uzawa, Y. Yamaguchi, H. Tanaka “The α-Glycosidation of Partially Unprotected N-Acetyl and N-Glycolyl Sialyl Donors in the Absence of a Nitrile Solvent Effect”, Chem. Eur. J., 22(20), 6968-6973 (2016). DOI:10.1002/chem.201601031.
        16. S. Irie, S. Fuse, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, H. Masui, H. Tanaka, T. Takahashi “Rapid Synthesis of D-A’-π-A Dyes via One-Pot Three-Component Suzuki-Miyaura Coupling and an Evaluation of the Photovoltaic Properties for Use in DSSCs”, Chem. Eur. J.22(7), 2507-2514 (2016). DOI:10.1002/chem.201504277.
        17. S. Fuse, R. Takahashi, M. M. Maitani, Y. Wada, T. Kaiho, H. Tanaka, T. Takahashi “Synthesis and Evaluation of Thiophene-based Organic Dyes Containing a Rigid and Non-Planar Donor with Secondary Electron Donors for Use in Dye-Sensitized Solar Cells”, Eur. J. Org. Chem., 3, 508-517 (2016). DOI:10.1002/ejoc.201501190.


        1. A. Sato, T. Itoh, S. Imamichi, S. Kikuhara, H. Fujimori, T. Hirai, S. Saito, Y. Sakurai, H. Tanaka, H. Nakamura, M. Suzuki, Y. Murakami, D. Baiseitov, K. Berikkhanova, Z. Zhumadilov, Y. Imahori, J. Itami, K. Ono, S. Masunaga, M. Masutani
          “Proteomic Analysis of Cellular Response Induced by Boron Neutron Capture Reaction in Human Squamous Cell Carcinoma SAS Cells”, Appl. Radiat. Isotope, 106, 213-219 (2015). DOI:10.1016/j.apradiso.2015.08.001
        2. S. Tachikawa, S. Sato, H. Hazama, Y. Kaneda, K. Awazu, H. Nakamura
          “Localization-Dependent Cell-Killing Effects of Protoporphyrin (PPIX)-Lipid Micelles and Liposomes in Photodynamic Therapy”, Bioorg. Med. Chem., 23(24), 7578-7584 (2015). DOI:10.1016/j.bmc.2015.11.001.
        3. 増井悠、布施新一郎、高橋孝志
          「ワンポット多成分連結反応を基盤とした機能性分子のコンビナトリアル合成」Organometallic News,  3, 100-104 (2015). 
        4. S. Sato, K. Nakamura, H. Nakamura
          “Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives”, ACS Chem. Biol., 10(11), 2633-2640 (2015). DOI:10.1021/acschembio.5b00440
        5. 布施新一郎
          「サイト選択的マイクロフロー反応を駆使する天然物合成」 化学と工業 68(8), 733-734 (2015). 
        6. S. Fuse, Y. Otake, Y. Mifune, H. Tanaka
          “A Facile Preparation of α-Aryl Carboxylic Acid via One-flow Arndt-Eistert Synthesis”, Aust. J. Chem., (invited)  68(11), 1657-1661 (2015). DOI:10.1071/CH15342
        7. S. Fuse, T. Morita, K. Johmoto, H. Uekusa, H. Tanaka
          “Directing Group/Protecting Group-Free Synthesis of Tetraaryl-Substituted Pyrazoles via Four Direct Arylations on an Unsubstituted Pyrazole Scaffold”, Chem. Eur. J., 21(41), 14370-14375 (2015). DOI:10.1002/chem.201502399Selected as an Inside Cover Picture, Selected as a Hot Paper
        8. H. Koganei, S. Tachikawa, M. E. El-Zaria, H. Nakamura
          “Synthesis of Oligo-closo-dodecaborates by Hüisgen Click Reaction as Encapsulated Agents for Preparation of High-Boron-Content Liposomes for Neutron Capture Therapy”, New J. Chem., 39, 6388-6394 (2015). DOI:10.1039/C5NJ00856E.
        9. H. Masui, N. Ishizawa, S. Fuse, T. Takahashi
          “Palladium-Catalyzed Double Carbonylation-Based Diversity-Oriented Synthesis of 3,4-Dihydroisoquinoline-1-Carboxamides”, Tetrahedron, 71(37), 6354-6360 (2015). DOI:10.1016/j.tet.2015.05.102
        10. G. Li, S. Azuma, H. Minegishi, H. Nakamura
          “Synthesis and Biological Evaluation of meta-Carborane-Containing phenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1”, J. Organomet. Chem., 798(1), 189-195 (2015). DOI:10.1016/j.jorganchem.2015.05.029.
        11. S. Fuse, H. Sugiyama, D. Kobayashi, Y. Iijima, K. Matsumura, H. Tanaka, T. Takahashi
          “Regio-Selective, One-pot, Three-component Synthesis of 1,3,4- and 1,3,5-Triaryl Pyrazoles from 1- and 2-Aryl-1-Alkenyl Sulfones”, Eur. J. Org. Chem., 21, 4756-4764 (2015). DOI:10.1002/ejoc.201500562
        12. T. Morita, D. Kobayashi, K. Matsumura, K. Johmoto, H. Uekusa, S. Fuse, T. Takahashi
          “Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles”, Chem. Asian J., 10(8), 1626-1630 (2015). DOI:10.1002/asia.201500362 Selected as a Front Cover Picture, Selected as Wiley Hottest Articles in Organic Chemistry
        13. 布施新一郎、高橋孝志
          「マイクロフロー光反応・イミドイル化反応・アシル化反応を駆使する効率的な有機合成」有機合成化学協会誌、73(5), 442-451 (2015). DOI:10.5059/yukigoseikyokaishi.73.442.
        14. S. Fuse, A. Ikebe, K. Oosumi, T. Karasawa, K. Matsumura, M. Izumikawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Doi, T. Takahashi
          “Asymmetric Total Synthesis of ent-Pyripyropene A”, Chem. Eur. J., 21(26), 9454-9460 (2015). DOI:10.1002/chem.201500703
        15. K. Matsumura, S. Yoshizaki, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, S. Fuse, H. Tanaka, T. Takahashi
          “Rapid Synthesis of Thiophene-Based, Organic Dyes for DSSCs via a One-Pot, Four-Component Coupling Approach”, Chem. Eur. J.21(27), 9742-9747 (2015). DOI:10.1002/chem.201500979.
        16. S. Fuse, R. Takahashi, T. Takahashi
          “Facile, One-Step Synthesis of 5-Substituted Thieno[3,4-c]pyrrole-4,6-dione by Palladium-Catalyzed Carbonylative Amidation”, Eur. J. Org. Chem., 16, 3430-3434 (2015). DOI:10.1002/ejoc.201500273.
        17. 山内将哉、本多典広、間久直、立川将士、中村浩之、金田安史、粟津邦男
          「抗腫瘍効果を持つ非ウイルスベクター用いた薬剤耐性前立腺がん細胞に対する高効率な光線力学療法」レーザー医学会 36(1), 18-24 (2015). DOI:10.2530/jslsm.jslsm-36_0002
        18. G. Li, S. Azuma, S. Sato, H. Minegishi, H. Nakamura
          “ortho-Carboranylphenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1Transcriptional Activity and Heat Shock Protein (HSP) 60 Chaperon Activity”, Bioorg. Med. Chem. Lett., 25(13), 2524-2628 (2015). DOI:10.1016/j.bmcl.2015.04.088.
        19. H. Minegishi, Y. Futamura, S. Fukashiro, M. Muroi, M. Kawatani, H. Osada, H. Nakamura
          “Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods”, J. Med. Chem., 58(10), 4230-4241 (2015). DOI:10.1021/acs.jmedchem.5b00035
        20. H. Nakamura
          “C(sp3)–H versus C(sp3)–C(sp) in Activation of Propargylic Amines under Transition-Metal Catalysis”, Synlett26(12), 1649-1664 (2015). DOI:10.1055/s-0034-1380462.
        21. H. S. Ban and H. Nakamura
          “Boron-Based Drug Design”, Chem. Rec., 15(3), 616-635 (2015). DOI:10.1002/tcr.201402100.
        22. S. Sato, K. Morita, H. Nakamura
          “Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst”, Bioconjugate Chem., 26(2), 250-256 (2015). DOI:10.1021/bc500518t.
        23. H. Nakamura, L. Tazaki, D. Kanoh, S. Sato
          “Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity”, Pure Appl. Chem., 87(2), 145-154 (2015). DOI:10.1515/pac-2014-0911.
        24. H. Nakamura, H. Koganei, T. Miyoshi, Y. Sakurai, K. Ono, M. Suzuki
          “Antitumor Effect of Boron Nitride Nanotubes in Combination with Thermal Neutron Irradiation on BNCT”, Bioorg. Med. Chem. Lett., 25(2), 172-174 (2015). DOI:10.1016/j.bmcl.2014.12.005.
        25. 中村浩之
          「ホウ素化合物・薬剤の歴史と現状」 RADIOISOTOPES, 64(1), 47-58 (2015). DOI:10.3769/radioisotopes.64.47.


        1. 粟津邦男、金田安史、山内将哉、中村浩之
          “薬剤耐性前立腺がん細胞へのPDTの検討 =非ウィルスベクターとPpIX脂質を用いた新規光感受性薬剤の開発=”, 月刊 光アライアンス 特集号「がんを抑え込む光線治療」, 25(9),, 17-22 (2014).
        2. 立川将士、中村浩之,
          “がん光線力学療法のためのDDS薬剤の開発:ポルフィリン脂質の開発とナノキャリアへの応用”, 月刊 光アライアンス 特集号「がんを抑え込む光線治療, 25(9), 12-16 (2014).
        3. S. Tachikawa, T. Miyoshi, H. Koganei, M. E. El-Zaria, C. Viñas, M. Suzuki, K. Ono, H. Nakamura,
          “Spermidinium Closo-dodecaborate-encapsulating Liposomes as Efficient Boron Delivery Vehicles for Neutron Capture Therapy”, Chem. Commun., 50(82), 12325-12328 (2014). LINK(open access)
        4. S. Tachikawa, M. E. El-Zaria, R. Inomata, S. Sato, H. Nakamura,
          “Protoporphyrin-Lipids: Their Synthesis, Liposomal Formation and Efficient Delivery to Tumor”, Bioorg. Med. Chem. 22(17), 4745–4751 (2014). LINK
        5. H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, S. Sato,
          “Design of Photoaffinity Probe Molecules for Identification and Modification of Target Proteins”, J. Photopolym. Sci. Technol., 27(4), 453-458 (2014). LINK
        6. S. Matsushima, K. Ohtsuka, H. Ohnishi, M. Fujiwara, H. Nakamura, T. Morii, H. Goto, T. Watanabe,
          “V843I, a Lung Cancer Predisposing EGFR Mutation, is Responsible for Resistance to EGFR Tyrosine Kinase Inhibitors”, J. Thor. Oncol., 9(9) 1377-1384 (2014). LINK
        7. T. Sugiishi, H. Nakamura,
          “Reactivity of Propargylic Amines in the Presence of Transition Metals”, J. Syn. Org. Chem., 72, 654-665 (2014).
        8. C. Verdia-Baguena, A. Alcaraz, V. M. Aguilella, A. M. Cioran, S. Tachikawa, H. Nakamura, F. Teixidor, C. Vinas,
          “Amphiphilic COSAN and I2-COSAN Crossing Synthetic Lipid Membranes: Planar Bilayers and Liposomes”, Chem. Commun., 50, 6700-6703 (2014). LINK
        9. H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, H. H. Ban,
          “Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors”, J. Chem. Soc. Dalton Trans., (invited), 43(13), 4941-4944 (2014). LINK
        10. M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu,
          “A novel photodynamic therapy for drug resistant prostate cancer cells using porphyrus Envelope as a novel photosensitizer”, Photodiag. Photodynam. Ther., 11(1), 48-54 (2014). LINK


        1. H. Nakamura
          “Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy”, Yakugaku Zasshi (Review), 133(12), 1297-1306 (2013). LINK
        2. S. Sato, H. Nakamura,
          “Ligand-directed Selective Protein Modification Based on Local Single Electron Transfer Catalysis”, Angew. Chem. Int. Ed., 52, 8681-8684 (2013). LINK
        3. H. Nakamura, Y. Yasui, H. S. Ban,
          “Synthesis and Biological Evaluation of ortho-Carborane Containing Benzoxazole as an Inhibitor of Hypoxia Inducible Factor (HIF)-1Transcriptional Activity”, J. Organomet. Chem. (special issue), 747, 189-194 (2013). LINK
        4. H. Minegishi, S. Fukashiro, H. S. Ban, H. Nakamura,
          “Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors”, ACS Med. Chem. Lett., 4, 297-301 (2013). LINK
        5. H. Nakamura
          “Boron Cluster Lipid Liposomes as New Vehicles for Boron Delivery System of Neutron Capture Therapy”, Future Med. Chem. (invited), 5(6), 715-730(2013). LINK
        6. M. Bialek-Pietras, A. B. Olejniczak, S. Tachikawa, H. Nakamura, Z. J. Lesnikowski,
          “Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their cholesterol conjugates”, Bioorg. Med. Chem., 21, 1136-1142 (2013). LINK
        7. H. Minegishi, T. Matsukawa, H. Nakamura,
          “Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity”, ChemMedChem, 8, 265-271 (2013). LINK Selected as an Inside Cover Picture
        8. H. Nakamura, Y. Yasui, M. Maruyama, H. Minegishi, H. S. Ban, S. Sato,
          “Development of Hypoxia-Inducible Factor (HIF)-1α Inhibitors: Effect of ortho-Carborane Substituents on HIF Transcriptional -Activity under Hypoxia”, Bioorg. Med. Chem. Lett. 23, 1455-1461 (2013). LINK
        9. H. Koganei, M. Ueno, S. Tachikawa, L. Tasaki, H. S. Ban, M. Suzuki, K. Shiraishi, K. Kawano, M. Yokoyama, Y. Maitani, K. Ono, H. Nakamura,
          “Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers”, Bioconjugate Chem., 24, 124-132 (2013). LINK
        10. H. Nakamura, H. Minegishi,
          “HSP60 as a drug target”, Curr. Pharm. Des. (Review), 19(3), 441-451 (2013). LINK


        1. 上田記子、小金井逸人、上野学、立川将士、鈴木実、小野公二、中村浩之
          “蛍光標識ホウ素脂質の開発とリポソーム化による細胞内イメージング”, Progress in Drug Delivery System XXI, 68-73 (2012).
        2. A. Takeuchi, M. Hori, S. Sato, H. S. Ban, T. Kuchimaru, S. Kizaka-Kondoh, T. Yamori, H. Nakamura,
          “Synthesis and Biological Evaluation of Furylindazoles as Hypoxia Inducible Factor (HIF)-1α Inhibitors”, Med. Chem. Commun. 3, 1455-1461 (2012). LINK
        3. M. Uno, Y. Koma, H. S. Ban, H. Nakamura,
          “Discovery of 1-[4-(N-Benzylamino)phenyl]-3-phenylurea Derivatives as Non-Peptidic Selective SUMO-Sentrin Specific Protease (SENP)1 Inhibitors”, Bioorg. Med. Chem. Lett., 22, 5169-5173 (2012). LINK
        4. Y. Kim, H. Nakamura,
          “Copper(I)-catalysed Deacetylenative Cross-coupling Reaction of Terminal Alkynes with Propargylic Amines via C(sp)-C(sp3) Bond Cleavage”, Synlett., 23, 1686-1690 (2012). LINK
        5. N. Fujimoto, M. Sakai, K. Ishii, H. Nakamura, Y. Kaneda, K. Awazu,
          “In vitro Investigation of Efficient Photodynamic Therapy Using Non-viral Vector; Hemagglutinating Virus of Japan Envelope”, J. Biomed. Opt., 17(7), 078002 (Jul 17, 2012). LINK
        6. H. S. Ban, K. Shimizu, H. Minegishi, H. Nakamura,
          “Identification of Heat Shock Protein 60 as the Regulator of the Hypoxia-inducible Factor Sub-unit HIF-1α”, Pure Appl. Chem., 84(11), 2325-2337 (2012). LINK
        7. H. Nakamura, H. Kuroda, H. Minegishi,
          “Synthesis and Biological Evaluation of Boronic Acid Containing Phenstatin Analogues”, ARKIVOC., 79-87 (2012, vii). LINK
        8. T. Sugiishi, H. Nakamura,
          “Zinc(II)-Catalyzed Redox Cross-Dehydrogenative Coupling of Propargylic Amines and Terminal Alkynes for Synthesis of N-Tethered 1,6-Enynes”, J. Am. Chem. Soc., 134, 2504-2507 (2012). LINK
        9. H. Nakamura, N. Ueda, H. B. Ban, M. Ueno, S. Tachikawa,
          “Design and Synthesis of Fluorescence-labeled Closo-dodecaborate Lipid: Liposome Formation and in vitro and in vivo Imaging Targeting to Tumor for Boron Neutron Capture Therapy”, Org. Biomol. Chem., 10, 1374-1380 (2012). LINK


        1. 中村浩之
          “今後、治療の多様化に適応できるホウ素薬剤の開発を”, エネルギーレビュー, 特集:岐路に立つホウ素中性子捕捉療法, 31(11), 17-18 (2011). LINK
        2. C.-H Lee, G. F. Jin, H. W. Lim, E. H. Yang, J.-D. Lee, H. Nakamura, H. S. Ban, S. O. Kang,
          “Facile Synthesis of 4-Substituted 3,4-Dihydro-1H-2,1,3-Benzothiadiazine 2,2-Dioxides”, Heteroatom Chem., 22, 192-197 (2011). LINK
        3. Y. Kim, H. Nakamura,
          “Copper(I)-catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes”, Chem. Eur. J., 17, 12561-12563 (2011). LINK
        4. H. Nakamura, A. Shoji, A. Takeuchi, H. B. Ban, J.-D. Lee, T. Yamori, S. O. Kang,
          “Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors”, Aust. J. Chem., 64(11), 1430-1437 (2011). LINK
        5. A. R. Genady, H. Nakamura,
          “Amphiphilic Allylation of Arylidene-1,3-oxazol-5(4H)-one Using Bis-π-allylpalladium Complexes: An Approach to Synthesis of Cyclohexyl and Cyclohexenyl α-Amino Acid”, Org. Biomol. Chem., 9, 7180-7189 (2011). LINK
        6. Y. Ito, T. Mizuno, K. Yoshino, H.S. Ban, H. Nakamura, J. Hiratsuka, A. Ishikawa, H. Ohki,
          “Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers”, Appl. Radiat. Isotope., 69(12), 1771-1773 (2011). LINK
        7. M. E. El-Zaria, H. Arii, H. Nakamura,
          “m-Carborane-Based Chiral NBN Pincer-Metal Complexes: Synthesis, Structure, and Application in Asymmetric Catalysis”, Inorg. Chem., 50(9), 4149-4161(2011). LINK
        8. H. S. Ban, Y. Uto, H. Nakamura,
          “Hypoxia-Inducible Factor Inhibitors: A Survey of Recent Patented Compounds (2004-2010)”, Exp. Opin. Ther. Patents (invited), 21(2),, 131-146 (2011). LINK
        9. H. Nakamura, K. Shimizu,
          “Catalytic Reactions of Bis-π-allylpalladium Generated from Allyltrifluoroborate”, Tetrahedron Lett., 52(3), 426-429 (2011). LINK



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